公开(公告)号：US20150073536A1

公开(公告)日：2015-03-12

申请号：US14121435

申请日：2014-09-04

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Richard Rapoza ,  Susan Veldhof ,  James Oberhauser ,  Syed F.A. Hossainy

IPC: A61F2/86 ,  A61L31/06 ,  A61L31/16 ,  A61L31/14

CPC classification number: A61F2/86 ,  A61F2/915 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/422 ,  C08L67/04

Abstract: A method of treating vascular disease in a patient is disclosed that comprises deploying a bioabsorbable polymer scaffold composed of a plurality of struts at a stenotic segment of an artery of a patient, wherein after the scaffold supports the segment at an increased diameter for a period of time the polymer degrades and is progressively replaced by de novo formation of malleable provisional matrix comprising proteoglycan, wherein as the scaffold becomes more malleable and becomes disconnected as it degrades, wherein following coverage of the struts by a neointima layer and loss of mechanical support provided by the scaffold, the scaffold is pulled outward by positive remodeling of the vessel wall of the scaffolded segment.

Abstract translation: 公开了一种治疗患者血管疾病的方法，其包括在患者的动脉的狭窄部分部署由多个支柱构成的生物可吸收聚合物支架，其中在所述支架之后以增加的直径支撑所述片段一段时间 聚合物降解的时间逐渐被包含蛋白多糖的可延展的临时基质的从头形成所替代，其中当支架变得更有韧性并且随着其降解而变得断裂，其中由新内膜层覆盖支柱并且由 通过骨架段的血管壁的正重构，支架被向外拉。

公开(公告)号：US10143572B2

公开(公告)日：2018-12-04

申请号：US14121435

申请日：2014-09-04

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Richard Rapoza ,  Susan Veldhof ,  James Oberhauser ,  Syed F. A. Hossainy

IPC: A61L27/54 ,  A61F2/86 ,  A61L31/14 ,  A61L31/06 ,  A61L31/16 ,  A61F2/915

Abstract: A method of treating vascular disease in a patient is disclosed that comprises deploying a bioabsorbable polymer scaffold composed of a plurality of struts at a stenotic segment of an artery of a patient, wherein after the scaffold supports the segment at an increased diameter for a period of time the polymer degrades and is progressively replaced by de novo formation of malleable provisional matrix comprising proteoglycan, wherein as the scaffold becomes more malleable and becomes disconnected as it degrades, wherein following coverage of the struts by a neointima layer and loss of mechanical support provided by the scaffold, the scaffold is pulled outward by positive remodeling of the vessel wall of the scaffolded segment.