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公开(公告)号：US10099431B2
公开(公告)日：2018-10-16
申请号：US14832283
申请日：2015-08-21
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed F. A. Hossainy , Manish B. Gada
Abstract: Methods of fabricating a polymer scaffold with increased radial strength including steps of elongation or strain of a biaxially oriented tube and annealing or thermal processing of the strained tube at a constant strain are disclosed. The steps of elongation and thermal processing increase axial direction chain orientation and lamellar crystal growth, increase radial strength, and decrease the thickness of the tube. The method allows fabrication of a scaffold with thinner struts which provide sufficient radial strength.
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2.发明授权Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same 有权用于包含乳酸聚合物的可植入装置的涂层及其制造方法公开(公告)号：US09408949B2
公开(公告)日：2016-08-09
申请号：US14476623
申请日：2014-09-03
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed F. A. Hossainy , Yiwen Tang , Eugene T. Michal , Thierry Glauser , Stephen D. Pacetti , Jessica DesNoyer
CPC classification number: A61L31/10 , A61F2250/0067 , A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2420/00 , A61L2420/02 , A61L2420/06 , C08L67/04
Abstract: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
Abstract translation: 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含乳酸聚合物。
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公开(公告)号：US09345668B2
公开(公告)日：2016-05-24
申请号：US14542983
申请日：2014-11-17
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： O. Mikael Trollsas , Michael H. Ngo , David J. Sherman , Syed F. A. Hossainy
IPC: A61F2/00 , A61K31/56 , A61K31/33 , A61K31/497 , A61L31/16 , A61L27/34 , A61K9/50 , A61K38/13 , A61K38/44 , A61K45/06 , A61L31/10 , A61K47/34 , A61K31/436
CPC classification number: A61L31/10 , A61K9/5031 , A61K9/5089 , A61K31/33 , A61K31/436 , A61K31/497 , A61K31/56 , A61K38/13 , A61K38/446 , A61K45/06 , A61K47/34 , A61L27/34 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2420/02 , C08L71/02 , C08L67/04
Abstract: The present invention provides an implantable device having a coating including a slow dissolving polymer or material and the methods of making and using the same.
Abstract translation: 本发明提供具有包含缓慢溶解性聚合物或材料的涂层的可植入装置及其制造和使用方法。
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公开(公告)号：US09180227B2
公开(公告)日：2015-11-10
申请号：US14053796
申请日：2013-10-15
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Florian N. Ludwig , Syed F. A. Hossainy , Srinivasan Sridharan , Carol Lee
CPC classification number: A61L31/10 , A61L27/34 , A61L27/50 , A61L27/54 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61M31/002
Abstract: Methods are disclosed for controlling the morphology and the release-rate of active agent from coating layers for medical devices comprising a polymer matrix and one or more active agents. The methods comprise fixing the morphology or phase distribution of the active agent prior to removing solvent from the coating composition. The coating layers can be used for controlled the delivery of an active agent or a combination of active agents.
Abstract translation: 公开了用于控制活性剂从包含聚合物基质和一种或多种活性剂的医疗装置的涂层的形态和释放速率的方法。 所述方法包括在从涂料组合物中除去溶剂之前固定活性剂的形态或相分布。 涂层可用于控制活性剂或活性剂的组合的递送。
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公开(公告)号：US09072665B2
公开(公告)日：2015-07-07
申请号：US13737842
申请日：2013-01-09
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Florian N. Ludwig , Syed F. A. Hossainy , Stephen D. Pacetti
CPC classification number: A61K9/0087 , A61K47/6907 , A61K47/6911 , A61K47/6913 , A61K47/6915 , A61K47/6935 , B82Y5/00
Abstract: A composition that includes nanoparticles with binding affinity for platelets, and methods for using this composition to treat vascular disease are disclosed.
Abstract translation: 公开了包含对血小板具有结合亲和力的纳米颗粒的组合物，以及使用该组合物治疗血管疾病的方法。
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Patent Agency Ranking
公开(公告)号：US08980364B2
公开(公告)日：2015-03-17
申请号：US14155217
申请日：2014-01-14
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yung-Ming Chen , Jason Van Sciver , Syed F. A. Hossainy , Stephen D. Pacetti
CPC classification number: B29C65/76 , A61F2/82 , A61F2/86 , A61F2/91 , A61F2210/0004 , A61F2210/0076 , A61F2240/001 , A61F2250/0067 , A61F2310/00389 , A61L31/14 , A61L31/148 , A61L2420/02 , B05D1/38 , B05D3/0254 , B05D3/0473 , B29C65/10 , B29K2067/046 , B29K2105/258 , B29L2031/7534
Abstract: Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed.
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公开(公告)号：US08871236B2
公开(公告)日：2014-10-28
申请号：US13911572
申请日：2013-06-06
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed F. A. Hossainy
IPC: A61L31/10 , A61L31/16 , A61K31/74 , A61K31/445
CPC classification number: A61L31/16 , A61K31/445 , A61K31/74 , A61L31/10 , C08L33/06
Abstract: A composition comprising a structural component comprising linear acrylic homopolymers or linear acrylic copolymers and a biobeneficial component comprising copolymers having an acrylate moiety and a biobeneficial moiety is disclosed. A medical article comprising the composition in the coating thereof and a method of fabricating the medical article are also disclosed.
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公开(公告)号：US20130129816A1
公开(公告)日：2013-05-23
申请号：US13737842
申请日：2013-01-09
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Florian N. Ludwig , Syed F. A. Hossainy , Stephen D. Pacetti
IPC: A61K9/00
CPC classification number: A61K9/0087 , A61K47/6907 , A61K47/6911 , A61K47/6913 , A61K47/6915 , A61K47/6935 , B82Y5/00
Abstract: A composition that includes nanoparticles with binding affinity for platelets, and methods for using this composition to treat vascular disease are disclosed.
Abstract translation: 公开了包含对血小板具有结合亲和力的纳米颗粒的组合物，以及使用该组合物治疗血管疾病的方法。
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公开(公告)号：US09439869B2
公开(公告)日：2016-09-13
申请号：US14086907
申请日：2013-11-21
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Florian N. Ludwig , Stephen D. Pacetti , Syed F. A. Hossainy , Dariush Davalian
IPC: A61K9/50 , A61K9/51 , A61K38/44 , A61K41/00 , A61K47/48 , A61L31/16 , B01J13/02 , B22F1/02 , B82Y5/00 , A61K9/00
CPC classification number: A61K9/5031 , A61K9/0004 , A61K9/0019 , A61K9/5115 , A61K9/5138 , A61K38/446 , A61K41/0052 , A61K47/6923 , A61K47/6925 , A61K47/6929 , A61K47/6931 , A61L31/16 , A61L2300/00 , A61L2400/06 , A61L2400/12 , B01J13/02 , B22F1/025 , B82Y5/00 , Y10S977/773 , Y10S977/906 , Y10T428/2991 , Y10T428/2998
Abstract: Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.
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10.发明授权公开(公告)号：US08623069B2
公开(公告)日：2014-01-07
申请号：US13758674
申请日：2013-02-04
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed F. A. Hossainy , David C. Gale
IPC: A61F2/06
CPC classification number: A61F2/91 , A61F2210/0004 , A61F2250/0018 , A61F2250/0042 , B29C35/0266 , B29C71/0063 , B29C71/02 , B29L2031/753
Abstract: A medical device such as a stent having selected regions with different material properties than other regions is disclosed. Selection and modification of the regions may be based on facilitating a desired mechanical behavior and/or therapeutic prophylactic property of the device.
Abstract translation: 公开了一种诸如具有与其它区域不同的材料特性的选定区域的支架的医疗装置。 区域的选择和修饰可以基于促进装置的期望的机械行为和/或治疗性预防性质。
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