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    Bioresorbable nitric oxide agonist prodrug scaffolds for vascular stents
    4.
    发明授权
    Bioresorbable nitric oxide agonist prodrug scaffolds for vascular stents 有权
    用于血管支架的生物可再吸收一氧化氮激动剂前药支架

    公开(公告)号：US08936635B2

    公开(公告)日：2015-01-20

    申请号：US13426948

    申请日：2012-03-22

    申请人： Wayne H Kaesemeyer

    发明人： Wayne H Kaesemeyer

    IPC分类号： A61F2/06 ,  A61L31/14 ,  A61L31/16

    CPC分类号： A61L31/148 ,  A61L31/16 ,  A61L2300/422 ,  A61L2300/434

    摘要： The present invention relates to a bioresorbable scaffold for a vascular stent comprising a nitric oxide agonist and a polymer comprising a lactide, a glycolide and a lactone. The nitric oxide agonist is a statin or a HMG CoA reductase inhibitor. The nitric oxide agonist may be coated on the polymer, incorporated within the polymer or chemically bonded to the polymer. The invention also relates to a method for treating atherothrombosclerotic occlusive disease of an artery comprising implanting into the artery a stent with a bioresorbable scaffold comprising a nitric oxide agonist and a polymer comprising a lactide, a glycolide and a lactone, wherein the nitric oxide agonist is exuded from or released from the bioresorbable scaffold.

    摘要翻译： 本发明涉及包含一氧化氮激动剂和包含丙交酯，乙交酯和内酯的聚合物的血管支架的生物可再吸收支架。 一氧化氮激动剂是他汀类或HMG辅酶A还原酶抑制剂。 一氧化氮激动剂可以涂覆在聚合物上，并入聚合物中或化学键合到聚合物上。 本发明还涉及用于治疗动脉粥样硬化性血管硬化闭塞性疾病的方法，其包括将包含一氧化氮激动剂的生物可再吸收支架和包含丙交酯，乙交酯和内酯的聚合物植入动脉内的支架，其中一氧化氮激动剂为 从生物可吸收支架中渗出或释放。

    Drug delivery device
    10.
    发明申请
    Drug delivery device 审中-公开
    给药装置

    公开(公告)号：US20050220836A1

    公开(公告)日：2005-10-06

    申请号：US10813976

    申请日：2004-03-31

    申请人： Robert Falotico ,  Theresa Scheuble ,  Gregory Kopia

    发明人： Robert Falotico ,  Theresa Scheuble ,  Gregory Kopia

    IPC分类号： A61K45/00 ,  A61F2/00 ,  A61F2/82 ,  A61F2/84 ,  A61K31/436 ,  A61K31/4745 ,  A61K31/573 ,  A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61M29/00 ,  A61M29/02 ,  A61M31/00 ,  A61M37/00 ,  A61P9/10

    CPC分类号： A61L31/16 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/422 ,  C08L27/16

    摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Therapeutic agents may also be delivered to the region of a disease site. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.

    摘要翻译： 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。 治疗剂也可以递送到疾病部位的区域。 此外，可以修改装置以促进内皮化。 可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。 此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。 医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。 此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。