公开(公告)号：US20160355886A1

公开(公告)日：2016-12-08

申请号：US15108012

申请日：2014-12-30

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Boon Ooi Patrick TAN ,  Masafumi MURATANI ,  Aditi QAMRA

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: The present invention is directed to methods for determining the activity of a promoter. The present invention further describes a method for determining the susceptibility of a subject to cancer and biomarkers for detecting cancer in a subject.

Abstract translation: 本发明涉及确定启动子活性的方法。 本发明还描述了一种用于确定受试者对癌症的敏感性和用于检测受试者中癌症的生物标志物的方法。

公开(公告)号：US20230080224A1

公开(公告)日：2023-03-16

申请号：US17798025

申请日：2021-02-05

Applicant: Agency for Science, Technology and Research

Inventor： William SUN ,  Boon Ooi Patrick TAN ,  Huajing WANG ,  Thai Leong YAP ,  Shin Yee HONG ,  Cheng-I WANG ,  Ching-Wen HUANG ,  Shuet Theng LEE ,  Kah Fei WAN ,  Jian Duan Johnathan NG

IPC: C07K16/40 ,  G01N33/573 ,  G01N33/574 ,  A61P35/00

Abstract: The invention relates to antigen-binding molecules that specifically binds ALPPL2 and/or ALPP but not ALPL or ALPI. It also relates to a pharmaceutical composition, an immunoconjugate and a chimeric antigen receptor comprising said antigen-binding molecules. The invention also relates to methods for reducing the expression or activity of ALPPL2 in a cancer cell and methods of treating a cancer in a subject.