公开(公告)号：US20220340684A1

公开(公告)日：2022-10-27

申请号：US17296184

申请日：2019-11-21

Applicant: Agency for Science, Technology and Research

Inventor： Cheng-I Wang ,  Patricia Ng ,  John Connolly ,  Chia Yin Lee

IPC: C07K16/40 ,  C07K14/47 ,  A61P37/04

Abstract: Fc regions comprising modification to increase the affinity of association between the Fc region and TRIM21 are disclosed. Also disclosed are constituent polypeptides of such Fc regions, antigen-binding molecules and immunogens comprising such Fc regions, and nucleic acids encoding and methods using such Fc regions, antigen-binding molecules and immunogens.

公开(公告)号：US10342865B2

公开(公告)日：2019-07-09

申请号：US15594167

申请日：2017-05-12

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  TESSA THERAPEUTICS PTE. LTD. ,  SINGAPORE HEALTH SERVICES PTE. LTD.

Inventor： John Connolly ,  Richard Hopkins ,  Han Chong Toh

IPC: A61K35/17 ,  C12Q1/68 ,  C12Q1/6886 ,  G01N33/574 ,  A61K39/245 ,  C12N7/00 ,  C12Q1/70 ,  A61K39/00

Abstract: A method for predicting whether a patient will be a long-term survivor on treatment of a disease by adoptive cell transfer (ACT), is disclosed comprising: (i) analyzing a blood-derived sample obtained from the patient for one or more prognostic markers of long-term survival on treatment of a disease by ACT, and; (ii) based on the analysis of step (i), predicting whether the patient will be a long-term survivor on treatment of the disease by ACT. Also disclosed are methods for treating a patient by ACT, methods for selecting a patient for treatment by ACT, and methods for selecting a patient for treatment of a disease by ACT.