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公开(公告)号：US10342865B2
公开(公告)日：2019-07-09
申请号：US15594167
申请日：2017-05-12
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , TESSA THERAPEUTICS PTE. LTD. , SINGAPORE HEALTH SERVICES PTE. LTD.
发明人： John Connolly , Richard Hopkins , Han Chong Toh
IPC分类号： A61K35/17 , C12Q1/68 , C12Q1/6886 , G01N33/574 , A61K39/245 , C12N7/00 , C12Q1/70 , A61K39/00
摘要： A method for predicting whether a patient will be a long-term survivor on treatment of a disease by adoptive cell transfer (ACT), is disclosed comprising: (i) analyzing a blood-derived sample obtained from the patient for one or more prognostic markers of long-term survival on treatment of a disease by ACT, and; (ii) based on the analysis of step (i), predicting whether the patient will be a long-term survivor on treatment of the disease by ACT. Also disclosed are methods for treating a patient by ACT, methods for selecting a patient for treatment by ACT, and methods for selecting a patient for treatment of a disease by ACT.
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公开(公告)号：US10052372B2
公开(公告)日：2018-08-21
申请号：US15290230
申请日：2016-10-11
发明人： Peter Wang , Chunxiao Wu
IPC分类号： A61K39/12 , A61K35/17 , A61K39/00 , C12N5/0783
CPC分类号： A61K39/0011 , A61K35/17 , A61K39/12 , A61K2035/124 , A61K2039/5154 , A61K2039/5158 , C12N5/0638 , C12N2500/32 , C12N2501/2302 , C12N2502/11 , C12N2502/1107 , C12N2502/99 , C12N2710/16034
摘要： A method of treating a cancer in a subject is disclosed, comprising: (1) isolating T cells from a subject; generating or expanding a population of T cells specific for a virus by a method comprising: stimulating T cells by culture in the presence of antigen presenting cells (APCs) presenting a peptide of the virus, wherein 10 to 25% of the media in which the cells are cultured is conditioned media obtained from a stimulation culture comprising T cells and APCs presenting a peptide of the virus; and (3) administering the generated or expanded population of T cells to a subject. Also disclosed are methods for generating or expanding a population of T cells specific for a virus.
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公开(公告)号：US20190381167A1
公开(公告)日：2019-12-19
申请号：US16445481
申请日：2019-06-19
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , TESSA THERAPEUTICS PTE. LTD. , SINGAPORE HEALTH SERVICES PTE. LTD.
发明人： John CONNOLLY , Richard HOPKINS , Han Chong TOH
IPC分类号： A61K39/245 , G01N33/574 , C12Q1/70 , C12N7/00 , C12Q1/6886 , C12Q1/68 , A61K35/17
摘要： A method for predicting whether a patient will be a long-term survivor on treatment of a disease by adoptive cell transfer (ACT), is disclosed comprising: (i) analysing a blood-derived sample obtained from the patient for one or more prognostic markers of long-term survival on treatment of a disease by ACT, and; (ii) based on the analysis of step (i), predicting whether the patient will be a long-term survivor on treatment of the disease by ACT. Also disclosed are methods for treating a patient by ACT, methods for selecting a patient for treatment by ACT, and methods for selecting a patient for treatment of a disease by ACT.
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4.发明申请公开(公告)号：US20170191034A1
公开(公告)日：2017-07-06
申请号：US15508897
申请日：2015-09-04
发明人： Shu WANG , Chunxiao WU , Jieming ZENG , Yovita Ida PURWANTI , Andrew KHOO
IPC分类号： C12N5/0784 , C12N5/095
CPC分类号： C12N5/0639 , A61K35/15 , A61K39/0011 , A61K2039/5154 , A61K2039/572 , C12N5/0695 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2502/30 , C12N2502/45 , C12N2506/30
摘要： The invention concerns a method of preparing a composition comprising stimulated immune system cells such as dendritic cells (DC) for use in inducing immune response of cytotoxic T lymphocytes against colorectal cancer. The dendritic cells are pulsed by contact with colorectal cancer stem cells (CSC) or their fragments thereof. These colorectal CSCs are produced by OSKM (Oct4, Sox2, Klf4 and c-Myc) induced reprogramming of differentiated colorectal cancer cells (CRC) which results in undifferentiated colorectal CSC-like cells. Both the CSC-like cells and the lysates of heat-shocked CSC-like cells could be used as an accessible source of tumour antigens for DC pulsing to induce specific immune responses against colorectal CSCs.
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公开(公告)号：US20170028042A1
公开(公告)日：2017-02-02
申请号：US15290230
申请日：2016-10-11
发明人： Peter WANG , Chunxiao WU
IPC分类号： A61K39/00 , C12N5/0783 , A61K39/245
CPC分类号： A61K39/0011 , A61K35/17 , A61K39/12 , A61K2035/124 , A61K2039/5154 , A61K2039/5158 , C12N5/0638 , C12N2500/32 , C12N2501/2302 , C12N2502/11 , C12N2502/1107 , C12N2502/99 , C12N2710/16034
摘要： A method of treating a cancer in a subject is disclosed, comprising: (1) isolating T cells from a subject; generating or expanding a population of T cells specific for a virus by a method comprising: stimulating T cells by culture in the presence of antigen presenting cells (APCs) presenting a peptide of the virus, wherein 10 to 25% of the media in which the cells are cultured is conditioned media obtained from a stimulation culture comprising T cells and APCs presenting a peptide of the virus; and (3) administering the generated or expanded population of T cells to a subject. Also disclosed are methods for generating or expanding a population of T cells specific for a virus.
摘要翻译： 公开了一种治疗受试者的癌症的方法，包括：（1）从受试者中分离T细胞; 通过包括以下方法产生或扩大特定于病毒的T细胞群：在存在呈现病毒肽的抗原呈递细胞（APC）的情况下通过培养来刺激T细胞，其中10至25％ 培养细胞是从包含T细胞的刺激培养物获得的条件培养基和呈现病毒肽的APC; 和（3）将所产生或扩增的T细胞群施用于受试者。 还公开了用于产生或扩增特异于病毒的T细胞群体的方法。
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公开(公告)号：US20200172864A1
公开(公告)日：2020-06-04
申请号：US16336058
申请日：2017-09-26
IPC分类号： C12N5/0783 , A61K35/17
摘要： The invention relates to the expansion of T cells and particularly, although not exclusively, to the expansion of gamma delta T cells, and the optimization of medium, serum and cytokine combinations for large-scale ex vivo expansion of gamma delta T cells for clinical use.
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公开(公告)号：US20190352373A1
公开(公告)日：2019-11-21
申请号：US16480391
申请日：2018-01-19
摘要： A TGF-β decoy receptor comprising a TGF-β binding region and a lipid anchor region is disclosed. Also disclosed is a chimeric antigen receptor (CAR) comprising a TGF-β binding region. Also disclosed are compositions comprising, and methods using, the TGF-β decoy receptors and CARs.
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公开(公告)号：US20190262397A1
公开(公告)日：2019-08-29
申请号：US16320055
申请日：2017-07-24
发明人： John Edward CONNOLLY , Dang L. VU
IPC分类号： A61K35/17 , A61P31/00 , C07K16/30 , C07K14/705
摘要： Chimeric Antigen Receptors (CARs) comprising a costimulatory sequence which is, or which is derived from, the intracellular domain of CD226, or a fragment thereof, are disclosed. Also disclosed are compositions comprising such CARs, and uses and methods using the same.
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公开(公告)号：US20180078627A1
公开(公告)日：2018-03-22
申请号：US15563542
申请日：2016-03-28
发明人： Jieming ZENG , Shu WANG , Andrew KHOO
IPC分类号： A61K39/00 , C12N5/0784 , C12N7/00 , C07K14/47 , C07K14/435
CPC分类号： A61K39/0011 , A61K35/15 , A61K2039/5154 , A61K2039/5156 , A61K2039/57 , A61K2039/572 , C07K14/435 , C07K14/4748 , C07K2319/95 , C12N5/0639 , C12N7/00 , C12N2501/22 , C12N2501/2304 , C12N2502/1394 , C12N2506/02 , C12N2510/00 , C12N2740/15043
摘要： There is provided a method of loading antigen in a dendritic cell for antigen presentation, the method comprising: modifying a pluripotent stem cell with a nucleic acid molecule encoding an antigen or one or more immunogenic epitopes thereof; inducing the pluripotent stem cell to differentiate into a dendritic cell that expresses and presents the antigen or the one or more immunogenic epitopes thereof. Dendritic cells, vaccines and methods of using the dendritic cells and vaccines are also provided.
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公开(公告)号：US20170312355A1
公开(公告)日：2017-11-02
申请号：US15594167
申请日：2017-05-12
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , TESSA THERAPEUTICS PTE. LTD. , SINGAPORE HEALTH SERVICES PTE. LTD.
发明人： John CONNOLLY , Richard HOPKINS , Han Chong TOH
IPC分类号： A61K39/245 , C12Q1/70 , G01N33/574 , C12N7/00 , A61K39/00
CPC分类号： A61K39/245 , A61K35/17 , A61K2039/5158 , A61K2039/545 , A61K2039/57 , A61K2039/572 , A61K2039/585 , C12N7/00 , C12N2710/16234 , C12N2710/16271 , C12Q1/68 , C12Q1/6886 , C12Q1/701 , C12Q1/705 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N33/574 , G01N33/57407 , G01N33/57423 , G01N33/57438 , G01N33/57446 , G01N2333/05 , G01N2333/521 , G01N2333/57 , G01N2800/52
摘要： A method for predicting whether a patient will be a long-term survivor on treatment of a disease by adoptive cell transfer (ACT), is disclosed comprising: (i) analysing a blood-derived sample obtained from the patient for one or more prognostic markers of long-term survival on treatment of a disease by ACT, and; (ii) based on the analysis of step (i), predicting whether the patient will be a long-term survivor on treatment of the disease by ACT. Also disclosed are methods for treating a patient by ACT, methods for selecting a patient for treatment by ACT, and methods for selecting a patient for treatment of a disease by ACT.
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