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公开(公告)号：US20200367756A1
公开(公告)日：2020-11-26
申请号：US16960306
申请日：2019-01-14
Applicant: Agency for Science, Technology and Research
Inventor： Malini Olivo , Kapil Dev , Dinish Unnimadhava Kurup Soudamini Amma , Renzhe Bi
Abstract: Provided are a system and a method for in vivo detection of adipose tissue browning. The system includes a fiber probe configured to illuminate light on an adipose tissue site; a spectrometer configured to obtain diffuse reflectance spectrum information from the adipose tissue site; a chromophore measure determining module configured to determine a fraction of lipid chromophore with respect to lipid chromophore and water chromophore based on spectrally unmixing the diffuse reflectance spectrum information in a region of 1050 nm to 1400 nm; and a browning detector module configured to detect adipose tissue browning based on the fraction determined above.
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公开(公告)号：US20230333011A1
公开(公告)日：2023-10-19
申请号：US18024873
申请日：2021-09-15
Applicant: Agency for Science, Technology and Research
Inventor： Kapil Dev , Ruochong Zhang , Chi Lok Wong , Shuyan Zhang , Dinish Unnimadhava Kurup Soudamini Amma , Malini Carolene Devapiriyai Olivo
IPC: G01N21/3563 , G01N21/64 , G01N21/84 , G01N21/359
CPC classification number: G01N21/3563 , G01N21/6456 , G01N21/84 , G01N21/359 , G01N2201/062 , G01N2201/08 , G01N2021/8466
Abstract: An optical system for imaging. The optical system includes light emitting diodes to provide light of predetermined wavelengths. The optical system further includes a charge-coupled device to receive the light emitted by one or more light emitting diodes and reflected by an object for fluorescence imaging of the object. The optical system additionally includes a broadband light source to provide broadband light. Furthermore, the optical system includes a spectrometer to receive the broadband light emitted by the broadband light source and reflected by the object for visible-near infrared-shortwave infrared spectroscopy of the object. Additionally, the optical system includes a hyperspectral camera to receive the broadband light emitted by the broadband light source and reflected by the object for hyperspectral imaging of the object as well as a controller coupled to the light emitting diodes, the broadband light source, the charge-coupled device, the spectrometer and the hyperspectral camera.
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公开(公告)号：US11635327B2
公开(公告)日：2023-04-25
申请号：US16499601
申请日：2018-03-29
Applicant: Agency for Science, Technology and Research
Inventor： Malini Olivo , Gurpreet Singh , Renzhe Bi , Kapil Dev , Dinish Unnimadhava Kurup Soudamini Amma , Chris Jun Hui Ho
Abstract: Provided is an optical probe, and a Raman spectroscopy system using such, including excitation and detection optics coupled to a sampling optics via a beam splitter, in confocal arrangement with a sample focal plane of the sampling optics. The detection optics is arranged to receive Raman signal from the sample focal plane and direct it onto a tip of a detection optical fiber. The optical probe may further include a positioning device mechanically coupled to the sampling optics and configured to control a position of the sample focal plane. In the Raman spectroscopy system a light source is coupled to the excitation optics via an excitation optical fiber, and a spectrometer is coupled to a detection optics via a detection optical fiber. Provided is further a method for measuring Raman signal depth profile in a sample, wherein sample's Raman spectra is measured and stored at different focal plane positions.
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公开(公告)号：US20200205664A1
公开(公告)日：2020-07-02
申请号：US16622038
申请日：2018-07-03
Applicant: Agency for Science, Technology and Research
Inventor： Jun Hui Chris Ho , Renzhe Bi , Chi Lok Dave Wong , Malini Olivo , Tao Yang , Zhongkang Lu , Weimin Huang , Kapil Dev
Abstract: There is provided a method for multi-modal imaging of tissue. The method includes: providing a fiber probe over a target area of the tissue, the fiber probe including a plurality of source fiber channels, a plurality of detector fiber channels and a plurality of fiducial marker channels, the plurality of source fiber channels, the plurality of detector fiber channels and the plurality of fiducial marker channels having a predetermined spatial arrangement in the fiber probe; directing light through each of the plurality of source fiber channels of the fiber probe to the target area in succession for performing optical imaging of the target area; obtaining optical imaging data of the target area based on attenuated light from the target area detected through the plurality of detector fiber channels due to said light directed to the target area; obtaining MRI data of the target area based on a MRI of the target area; and coregistering the optical imaging data and the MRI data based on a plurality of fiducial features captured in the MRI data corresponding to the plurality of fiducial marker channels of the fiber probe. There is also provide a corresponding system for multi-modal imaging of tissue.
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