公开(公告)号：US11053496B2

公开(公告)日：2021-07-06

申请号：US16310395

申请日：2017-06-14

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Prabha Sampath ,  Sundaram Gopinath ,  Shan Quah

IPC: A61K48/00 ,  C07H21/04 ,  C12N15/113 ,  A61P35/04 ,  A61P35/00 ,  A61K31/713

Abstract: The present invention refers to a method of treating a carcinoma by administration of one or more of an oligonucleotide comprising the sequence of miR-198 (SEQ ID NO: 1) or a functional part thereof, or an oligonucleotide which reduces expression of Follistatin-related protein 1 (FSTL1), Protein diaphanous homolog 1 (DIAPH1), Laminin subunit gamma-2 (LAMC2) or Urokinase-type plasminogen activator (PLAU). Preferably, the at least one or more oligonucleotides directed against FSTL1, DIAPH1, LAMC2 or PLAU is a shRNA or siRNA. Also provided is a method of determining the presence of carcinoma in a subject, comprising detecting and comparing the presence of miR-198 and/or at least one of FSTL1, DIAPH1, LAMC2 or PLAU, miR-181a, epidermal growth factor (EGF), and epidermal growth factor receptor (EGFR), and comparing the detected levels with that in a control sample.

公开(公告)号：US10071115B2

公开(公告)日：2018-09-11

申请号：US15389013

申请日：2016-12-22

Applicant: Agency for Science, Technology and Research

Inventor： Prabha Sampath

IPC: C12N15/11 ,  C07H21/02 ,  C07H21/04 ,  A61K48/00 ,  A61K31/7088 ,  A61K38/18 ,  A61K38/17 ,  C12Q1/6883 ,  G01N33/68

CPC classification number: A61K31/7088 ,  A61K38/1709 ,  A61K38/1841 ,  C12N15/113 ,  C12N15/1136 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/316 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/3517 ,  C12N2320/31 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/6887 ,  G01N2333/4704 ,  G01N2800/20 ,  C12N2310/3525 ,  A61K2300/00

Abstract: Disclosed is a method of promoting wound healing or wound closure. The method comprises administration of a miR-198 inhibitor and/or a follistatin-like-1 (FSTL1) polypeptide. Also disclosed are method of treating chronic cutaneous wounds, method of identifying a non-healing wound, use and a pharmaceutical composition comprising a miR-198 inhibitor and/or a follistatin-like-1 (FSTL1) polypeptide.

公开(公告)号：US09545420B2

公开(公告)日：2017-01-17

申请号：US14417763

申请日：2013-07-29

Applicant: Agency for Science, Technology and Research

Inventor： Prabha Sampath

IPC: A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/11 ,  A61K31/7088 ,  A61K38/17 ,  C12N15/113

CPC classification number: A61K31/7088 ,  A61K38/1709 ,  A61K38/1841 ,  C12N15/113 ,  C12N15/1136 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/316 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/3517 ,  C12N2320/31 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/6887 ,  G01N2333/4704 ,  G01N2800/20 ,  C12N2310/3525 ,  A61K2300/00

Abstract: Disclosed is a method of promoting wound healing or wound closure. The method comprises administration of a miR-198 inhibitor and/or a follistatin-like-1 (FSTL1) polypeptide. Also disclosed are method of treating chronic cutaneous wounds, method of identifying a non-healing wound, use and a pharmaceutical composition comprising a miR-198 inhibitor and/or a follistatin-like-1 (FSTL1) polypeptide.

Abstract translation: 公开了一种促进伤口愈合或伤口闭合的方法。 该方法包括施用miR-198抑制剂和/或卵泡抑素样-1（FSTL1）多肽。 还公开了治疗慢性皮肤伤口的方法，鉴定非愈合伤口的方法，用途和包含miR-198抑制剂和/或卵泡抑素样-1（FSTL1）多肽的药物组合物。

公开(公告)号：US20160244758A1

公开(公告)日：2016-08-25

申请号：US15041867

申请日：2016-02-11

Applicant: Agency for Science, Technology and Research

Inventor： Prabha Sampath

IPC: C12N15/113

CPC classification number: C12N15/113 ,  A61K31/7088 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/531 ,  C12N2320/30 ,  C12N2740/16043 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178 ,  C12N2310/321 ,  C12N2310/3521 ,  C12N2310/3525

Abstract: Methods for malignant glioma diagnosis/prognosis using miR-138 as a prognostic biomarker and methods for treating malignant glioma and inhibiting glioma stem cell growth by suppressing miR-138. Also disclosed herein are pharmaceutical compositions for use in treating malignant glioma, prolonging survival of malignant glioma patients, or eliminating GSCs and in turn tumor growth, the pharmaceutical composition comprising an oligonucleotide that targets miR- 138.

Abstract translation: 使用miR-138作为预后生物标志物的恶性胶质瘤诊断/预后的方法和通过抑制miR-138治疗恶性胶质瘤和抑制胶质瘤干细胞生长的方法。 本文还公开了用于治疗恶性胶质瘤的药物组合物，延长恶性胶质瘤患者的存活，或消除GSC，进而肿瘤生长，包含靶向miR-138的寡核苷酸的药物组合物。

公开(公告)号：US20150290289A1

公开(公告)日：2015-10-15

申请号：US14417763

申请日：2013-07-29

Applicant: Agency for Science, Technology and Research

Inventor： Prabha Sampath

IPC: A61K38/18 ,  A61K31/7088 ,  C12N15/113 ,  A61K38/17

CPC classification number: A61K31/7088 ,  A61K38/1709 ,  A61K38/1841 ,  C12N15/113 ,  C12N15/1136 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/316 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/3517 ,  C12N2320/31 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/6887 ,  G01N2333/4704 ,  G01N2800/20 ,  C12N2310/3525 ,  A61K2300/00

Abstract: Disclosed is a method of promoting wound healing or wound closure. The method comprises administration of a SmiR-198 inhibitor and/or a follistatin-like-1 (FSTL1) polypeptide. Also disclosed are method of treating chronic cutaneous wounds. method of identifying a non-healing wound, use and a pharmaceutical composition comprising a miR-198 inhibitor and/or a follistatin-like-1 (FSTL1) polypeptide.

Abstract translation: 公开了促进伤口愈合或伤口闭合的方法。 该方法包括施用SmiR-198抑制剂和/或卵泡抑素样-1（FSTL1）多肽。 还公开了治疗慢性皮肤创伤的方法。 识别非愈合伤口的方法，用途和包含miR-198抑制剂和/或卵泡抑素样-1（FSTL1）多肽的药物组合物。

公开(公告)号：US10472626B2

公开(公告)日：2019-11-12

申请号：US15500022

申请日：2015-07-31

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Prabha Sampath

IPC: C12N15/11 ,  C12N15/113 ,  A61K31/7088

Abstract: Disclosed is a modified oligonucleotide capable of reducing or inhibiting one or more activities miR-138. The modified oligonucleotide may comprise at least one locked nucleic acid (LNA) and wherein the oligonucleotide is substantially complementary to a nucleotide sequence of miR-138. Also disclosed are pharmaceutical compositions comprising the oligonucleotides, methods of using the oligonucleotides and uses thereof.

公开(公告)号：US20170202866A1

公开(公告)日：2017-07-20

申请号：US15389013

申请日：2016-12-22

Applicant: Agency for Science, Technology and Research

Inventor： Prabha Sampath

IPC: A61K31/7088 ,  G01N33/68 ,  C12Q1/68 ,  A61K38/18 ,  A61K38/17

CPC classification number: A61K31/7088 ,  A61K38/1709 ,  A61K38/1841 ,  C12N15/113 ,  C12N15/1136 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/316 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/3517 ,  C12N2320/31 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/6887 ,  G01N2333/4704 ,  G01N2800/20 ,  C12N2310/3525 ,  A61K2300/00

Abstract: Disclosed is a method of promoting wound healing or wound closure. The method comprises administration of a miR-198 inhibitor and/or a follistatin-like-1 (FSTL1) polypeptide. Also disclosed are method of treating chronic cutaneous wounds, method of identifying a non-healing wound, use and a pharmaceutical composition comprising a miR-198 inhibitor and/or a follistatin-like-1 (FSTL1) polypeptide.