公开(公告)号：US10071115B2

公开(公告)日：2018-09-11

申请号：US15389013

申请日：2016-12-22

申请人： Agency for Science, Technology and Research

发明人： Prabha Sampath

IPC分类号： C12N15/11 ,  C07H21/02 ,  C07H21/04 ,  A61K48/00 ,  A61K31/7088 ,  A61K38/18 ,  A61K38/17 ,  C12Q1/6883 ,  G01N33/68

CPC分类号： A61K31/7088 ,  A61K38/1709 ,  A61K38/1841 ,  C12N15/113 ,  C12N15/1136 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/316 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/3517 ,  C12N2320/31 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/6887 ,  G01N2333/4704 ,  G01N2800/20 ,  C12N2310/3525 ,  A61K2300/00

摘要： Disclosed is a method of promoting wound healing or wound closure. The method comprises administration of a miR-198 inhibitor and/or a follistatin-like-1 (FSTL1) polypeptide. Also disclosed are method of treating chronic cutaneous wounds, method of identifying a non-healing wound, use and a pharmaceutical composition comprising a miR-198 inhibitor and/or a follistatin-like-1 (FSTL1) polypeptide.

公开(公告)号：US20180196064A1

公开(公告)日：2018-07-12

申请号：US15897455

申请日：2018-02-15

申请人： Shiseido Company, Ltd. ,  ETH Zurich

发明人： Yuzo Yoshida ,  Kentaro Kajiya ,  Michael Detmar

IPC分类号： G01N33/68 ,  C12Q1/6881 ,  G01N33/50

CPC分类号： G01N33/6881 ,  C12Q1/6881 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5044 ,  G01N2333/4703 ,  G01N2500/10 ,  G01N2800/20

摘要： The present invention relates to a method of evaluating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in a harvested skin sample, and a method of evaluating a drug for improving, preventing or treating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in cultured cells.

公开(公告)号：US20180196050A1

公开(公告)日：2018-07-12

申请号：US15525655

申请日：2015-11-05

申请人： University of Newcastle Upon Tyne

发明人： Marie Labus ,  Penny Lovat ,  Robert Ellis

IPC分类号： G01N33/574

CPC分类号： G01N33/5743 ,  G01N2800/20 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/7028

摘要： The present invention relates inter alia to therapeutic agents for use in the treatment of melanoma, methods of diagnosing an increased risk of metastasis in a subject suffering from melanoma, methods of treating such subjects, diagnostic assays and kits. More particularly, in certain embodiments the invention relates to identifying whether a subject suffering from melanoma has an increased risk of metastasis by determining the expression of Ambra-1 and Loricrin in a tissue sample obtained from the subject.

公开(公告)号：US09862986B2

公开(公告)日：2018-01-09

申请号：US14583083

申请日：2014-12-24

申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

发明人： Bruno Reversade ,  Stefan Mundlos

IPC分类号： C12Q1/26 ,  C12N9/06 ,  C12N15/113 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/573 ,  A61K38/00

CPC分类号： C12Q1/26 ,  A61K38/00 ,  C12N9/0028 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/3233 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Y105/01002 ,  G01N33/5088 ,  G01N33/573 ,  G01N2333/90661 ,  G01N2800/20

摘要： The invention relates to muteins of the pyrroline-5-carboxylate reductase 1 (PYCR1), to nucleic acid molecules comprising a nucleotide sequence encoding such muteins, to methods of determining in a subject a predisposition of having an age related disorder associated with PYCR1, to methods of identifying a compound capable of modifying the expression of PYCR1, and methods of treating a subject having an age-related disorder associated with PYCR1. The invention further relates to a genetically modified animal and a method of modifying the expression of the PYCR1 gene in an animal.

公开(公告)号：US09745629B2

公开(公告)日：2017-08-29

申请号：US15196393

申请日：2016-06-29

申请人： CHANEL PARFUMS BEAUTE

发明人： Elena Fedorova ,  Christelle Lasserre

IPC分类号： C12Q1/68 ,  G01N33/50 ,  G01N33/68 ,  A61K8/34 ,  A61Q19/00 ,  A61Q19/08 ,  A61K8/06 ,  A61K8/73 ,  A61K8/81 ,  A61K8/92

CPC分类号： C12Q1/6876 ,  A61K8/062 ,  A61K8/345 ,  A61K8/347 ,  A61K8/735 ,  A61K8/8152 ,  A61K8/92 ,  A61K2800/78 ,  A61Q19/004 ,  A61Q19/007 ,  A61Q19/08 ,  C12Q2600/148 ,  C12Q2600/158 ,  C12Y208/02 ,  G01N33/5023 ,  G01N33/5044 ,  G01N33/6881 ,  G01N2333/91194 ,  G01N2800/20

摘要： The identification and the use of compounds which activate the expression of at least one gene selected from LARGE, HS6ST2 and ST8SIA1 is provided. An in vitro method for screening for candidate compounds includes: (a) bringing at least one test compound in contact with a sample of keratinocytes in vitro; (b) measuring the expression of at least one gene selected from LARGE, HS6ST2 and ST8SIA1, in the keratinocytes; and (c) selecting the compounds for which an activation of at least 1.4 fold of the expression of at least one of the LARGE, HS6ST2 and ST8SIA1 genes is measured in the keratinocytes treated in (a) compared with the untreated keratinocytes. The candidate compounds may be useful for preventing and/or attenuating ageing, and/or for hydrating skin.

公开(公告)号：US20170239159A1

公开(公告)日：2017-08-24

申请号：US15519334

申请日：2014-10-16

申请人： AMOREPACIFIC CORPORATION

发明人： Yong Deog HONG ,  Kyum Son KIM ,  Jun Seong PARK ,  Sang Hoon HAN

IPC分类号： A61K8/49 ,  G01N33/50 ,  A61K8/37 ,  A61Q19/00 ,  A61Q19/08

CPC分类号： A61K8/498 ,  A61K8/375 ,  A61K2800/74 ,  A61Q19/00 ,  A61Q19/008 ,  A61Q19/08 ,  G01N33/5023 ,  G01N33/5044 ,  G01N33/80 ,  G01N2800/20

摘要： The present invention relates to a composition containing a material for regulating the expression of ABH antigens and, more specifically, to a composition capable of: controlling sebum production and alleviating skin trouble by regulating the expression of ABH antigens; preventing skin pore enlargement by providing antioxidant effects; and defending against skin irritation production.

公开(公告)号：US20170100313A1

公开(公告)日：2017-04-13

申请号：US15370528

申请日：2016-12-06

申请人： Zhenyu Huang

发明人： Elisabeth S. Papazoglou ,  Zhenyu Huang

IPC分类号： A61K8/34 ,  A61K9/127 ,  A61Q19/08 ,  A61K31/05 ,  A61K8/14 ,  A61Q17/04

CPC分类号： A61K8/347 ,  A61K8/14 ,  A61K9/127 ,  A61K31/05 ,  A61K2800/782 ,  A61Q17/04 ,  A61Q19/08 ,  C12Q1/686 ,  G01N33/573 ,  G01N2333/912 ,  G01N2800/20 ,  G01N2800/40

摘要： One aspect of the invention provides a method of inhibiting, protecting against, or treating UVR-induced skin damage in a mammal at risk of developing UVR-induced skin damage. The method includes the step of topically administering a pharmaceutical or cosmetic composition including an effective amount of a Syk kinase inhibitor to said mammal. The Syk kinase inhibitor inhibits the UVR-induced skin damage in the mammal. Another aspect of the invention provides a method of treating a disease or disorder associated with a change of Syk kinase expression in the skin in a mammal. The method includes the step of topically administering to said skin of said mammal a pharmaceutical or cosmetic composition including a therapeutically effective amount of at least one Syk kinase inhibitor, thereby reducing Syk kinase expression in the skin of the mammal and treating the disease or disorder.

公开(公告)号：US09610037B2

公开(公告)日：2017-04-04

申请号：US14091805

申请日：2013-11-27

申请人： Elwha LLC

发明人： Michael H. Baym ,  Roderick A. Hyde ,  Jordin T. Kare ,  Eric C. Leuthardt ,  Gary L. McKnight ,  Tony S. Pan ,  Elizabeth A. Sweeney ,  Clarence T. Tegreene ,  Lowell L. Wood, Jr.

IPC分类号： A61B5/00 ,  A61B10/02 ,  G01N33/569 ,  A61B90/00 ,  A61B90/98

CPC分类号： A61B5/445 ,  A61B5/0002 ,  A61B5/0077 ,  A61B5/0095 ,  A61B5/443 ,  A61B5/4839 ,  A61B5/486 ,  A61B5/7246 ,  A61B10/02 ,  A61B90/98 ,  A61B2010/0225 ,  A61B2090/3941 ,  A61B2090/3975 ,  G01N33/56911 ,  G01N33/56938 ,  G01N2800/20

摘要： Devices and systems for sampling and profiling microbiota of skin are described which include a replaceable microbe sampling unit including a substrate and a location information storage component, the substrate including a microbe-capture region configured to capture at least one type of microbe from one or more regions of a skin surface of an individual, and the location information storage component configured to store information associated with the location of said one or more regions of the skin surface of the individual.

公开(公告)号：US09557341B2

公开(公告)日：2017-01-31

申请号：US13133520

申请日：2009-12-11

申请人： Somnuek Sungkanuparph ,  Sasisopin Kiertiburanakul ,  Thanyachai Sura ,  Wasun Chantratita ,  Soranun Chantarangsu ,  Angkana Charoenyingwattana ,  Surakameth Mahasirimongkol ,  Michiaki Kubo ,  Taisei Mushiroda ,  Yusuke Nakamura

发明人： Somnuek Sungkanuparph ,  Sasisopin Kiertiburanakul ,  Thanyachai Sura ,  Wasun Chantratita ,  Soranun Chantarangsu ,  Angkana Charoenyingwattana ,  Surakameth Mahasirimongkol ,  Michiaki Kubo ,  Taisei Mushiroda ,  Yusuke Nakamura

IPC分类号： C12Q1/68 ,  G01N33/94 ,  G01N33/68

CPC分类号： G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/94 ,  G01N33/9493 ,  G01N2800/20 ,  G01N2800/50

摘要： The present invention provides a method of predicting the risk of a patient for developing cutaneous adverse drug reaction to non-nucleoside reverse transcriptase inhibitors such as nevirapine by using HLA-B*3505 allele and/or polymorphisms in the CCHCR1 gene.

摘要翻译： 本发明提供一种通过使用CCHCR1基因中的HLA-B * 3505等位基因和/或多态性来预测患者对非核苷逆转录酶抑制剂如奈韦拉平发生皮肤不良药物反应的风险的方法。

公开(公告)号：US09480674B2

公开(公告)日：2016-11-01

申请号：US14536507

申请日：2014-11-07

申请人： Jean Hilaire Saurat

发明人： Jean Hilaire Saurat

IPC分类号： A61K31/352 ,  A61K47/10 ,  A61K45/06 ,  A61K9/00 ,  G01N33/68 ,  G01N33/50

CPC分类号： A61K31/352 ,  A61K9/0014 ,  A61K45/06 ,  A61K47/10 ,  G01N33/5088 ,  G01N33/6893 ,  G01N2800/20

摘要： The subject invention provides a method of treating acne in a subject which comprises topically and periodically applying to the subject's acne a composition comprising 3-phenyl-1-benzo[f]chromen-1-one and a pharmaceutically acceptable carrier, wherein the 3-phenyl-1-benzo[f]chromen-1-one is present in an amount effective to treat the subject's acne. The subject invention also provides a method of treating a skin condition associated with abnormal sebum secretion or abnormal sebaceous gland function in a subject, compositions in such methods and a sorting method for identifying agonists of AhR pathway, useful in such methods and compositions.

摘要翻译： 本发明提供一种治疗受试者的痤疮的方法，该方法包括局部地和周期性地向受试者的痤疮施用包含3-苯基-1-苯并[f]苯甲酸-1-酮和药学上可接受的载体的组合物，其中3- 苯基-1-苯并[f]苯甲酸-1-酮以有效治疗受试者的痤疮的量存在。 本发明还提供了一种治疗与受试者异常皮脂分泌或异常皮脂腺功能相关的皮肤病症的方法以及用于鉴定在这些方法和组合物中有用的这些方法的组合物和用于鉴定AhR通路激动剂的分选方法。