公开(公告)号：US20190315822A1

公开(公告)日：2019-10-17

申请号：US16416050

申请日：2019-05-17

Applicant: Amgen Inc.

Inventor： Yumei XIONG ,  Yi ZHANG ,  Jackie Z. SHENG ,  Agnes Eva HAMBURGER ,  Murielle M. VENIANT-ELLISON ,  Grant SHIMAMOTO ,  Xiaoshan MIN ,  Zhulun WANG ,  Jie TANG ,  Gunasekaran KANNAN ,  Kenneth W. WALKER ,  Bryan LEMON

IPC: C07K14/475 ,  A61K38/00 ,  C07K14/51 ,  A61K39/00 ,  A61K38/17 ,  A61K38/18 ,  C07K14/495 ,  A61K38/16

Abstract: GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

公开(公告)号：US20170291929A1

公开(公告)日：2017-10-12

申请号：US15625891

申请日：2017-06-16

Applicant: Amgen Inc.

Inventor： Yumei XIONG ,  Yi ZHANG ,  Jackie Z. SHENG ,  Agnes Eva HAMBURGER ,  Murielle M. VENIANT-ELLISON ,  Grant SHIMAMOTO ,  Xiaoshan MIN ,  Zhulun WANG ,  Jie TANG ,  Gunasekaran KANNAN ,  Kenneth W. WALKER ,  Bryan LEMON

IPC: C07K14/475 ,  A61K39/00

CPC classification number: C07K14/475 ,  A61K38/00 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K39/0005 ,  A61K2039/6056 ,  C07K14/495 ,  C07K14/51 ,  C07K2319/30

Abstract: GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.