公开(公告)号：US11572374B2

公开(公告)日：2023-02-07

申请号：US17266466

申请日：2019-08-13

Applicant: Amgen Inc. ,  Carmot Therapeutics, Inc.

Inventor： John R. Butler ,  Daniel Erlanson ,  Russell Graceffa ,  Jeffrey Iwig ,  Joon Won Jeong ,  Ryan D. White ,  Yongwei Wu ,  Shuyan Yi ,  Xiao Mei Zheng ,  Jesse M. McFarland ,  Abhisek Banerjee

IPC: C07D519/00 ,  C07D487/18

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

公开(公告)号：US11053226B2

公开(公告)日：2021-07-06

申请号：US16687546

申请日：2019-11-18

Applicant: Amgen Inc.

Inventor： Youngsook Shin ,  Victor J. Cee ,  Christopher M. Tegley ,  Brian Alan Lanman ,  Ryan Paul Wurz ,  Kevin C. Yang ,  Vu Van Ma ,  Daniel Erlanson ,  Joon Won Jeong ,  Raymond V. Fucini ,  Jeffrey Iwig

IPC: C07D403/14 ,  C07D401/14 ,  C07D403/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  A61P35/00

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.