Microwave induced single step green synthesis of some novel 2-aryl aldehydes and their analogues
    9.
    发明授权
    Microwave induced single step green synthesis of some novel 2-aryl aldehydes and their analogues 失效
    微波诱导单步绿色合成一些新型2-芳基醛及其类似物

    公开(公告)号:US08779200B2

    公开(公告)日:2014-07-15

    申请号:US13203100

    申请日:2010-02-25

    IPC分类号: C07C241/00 C07C47/00

    摘要: The present invention provides a process for the preparation of some novel 2-aryl and 2,2-diaryl aldehydes and analogues which are privileged intermediates for commercially important nonsteroidal anti-inflammatory drugs including naproxen, flurbiprofen and potent anticancer drug candidates, including phenstatin through a unique single step synthetic methodology utilizing easily available substrates in the form of aryl alkenes as well as environmentally benign aqueous reaction conditions in the form of solvents such as mixtures of water and DMSO or Dioxane and reagents N-bromosuccinimide, N-iodosuccinimide, N-cholorosuccinimide and phase transfer catalyst such as cetyltrimethyl ammonium bromide, N-hexyl ammonium chloride for a reaction time varying from 1 min-30 min, depending upon microwave or conventional heating, without using expensive transition metal catalysts or lewis acids/bases with yield varying from 35-55%, depending upon the solvent and substrate used. The developed method provides a clean and convenient alternative to access a diverse range of medicinally important 2-aryl and 2,2-diaryl aldehyde based scaffolds in lieu of the conventional multistep protocols employing expensive and hazardous transition metal catalysts and lewis acids/bases.

    摘要翻译: 本发明提供了一种制备一些新的2-芳基和2,2-二芳基醛和类似物的方法,其是用于商业上重要的非甾族抗炎药物的特权中间体,包括萘普生,氟比洛芬和有效的抗癌药物候选物,包括通过 使用易于获得的芳基烯烃底物的独特的单步合成方法以及溶剂形式的环境友好的水性反应条件,例如水和DMSO或二恶烷的混合物以及试剂N-溴琥珀酰亚胺,N-碘代琥珀酰亚胺,N-氯代氯代琥珀酰亚胺 和相转移催化剂如十六烷基三甲基溴化铵,N-己基氯化铵,反应时间为1分钟-30分钟,取决于微波或常规加热,不使用昂贵的过渡金属催化剂或路易斯酸/碱,产率从35 -55%,这取决于所用的溶剂和底物。 开发的方法提供了一种干净和方便的替代方案,以便获得各种各样的药物重要的2-芳基和2,2-二芳基醛基支架,代替常规的多步骤方案,其采用昂贵且危险的过渡金属催化剂和路易斯酸/碱。

    RFID SYSTEM WITH CONFIGURABLE RF PORT
    10.
    发明申请
    RFID SYSTEM WITH CONFIGURABLE RF PORT 有权
    具有可配置RF端口的RFID系统

    公开(公告)号:US20130342318A1

    公开(公告)日:2013-12-26

    申请号:US13532826

    申请日:2012-06-26

    IPC分类号: G06K7/01

    CPC分类号: G06K19/07327

    摘要: An active RFID tag has an antenna inside RF-blocking enclosure having a port with a selected shortest dimension. An RFID reader located outside the enclosure at a reader position transmits a downlink RF signal through the port as a directional RF signal on a downlink carrier frequency corresponding to a downlink wavelength smaller than the selected shortest dimension. The port is selectively configured so that the directional downlink RF signal can pass through the port in an access mode during a selected access time interval and are attenuated by at least 60 dB in a restricted mode during a selected restricted time interval that does not overlap with the access time interval.

    摘要翻译: 有源RFID标签在具有选定的最短尺寸的端口的RF阻挡外壳内具有天线。 位于读取器位置外部的RFID读取器通过端口将下行链路RF信号作为对应于小于所选择的最短维度的下行链路波长的下行链路载波上的定向RF信号来发送。 端口被选择性地配置为使得定向下行链路RF信号可以在所选择的访问时间间隔期间以访问模式通过端口,并且在受限模式期间在与第一接入时间间隔不重叠的选择的限制时间间隔期间衰减至少60dB 访问时间间隔。