公开(公告)号：US20210060168A1

公开(公告)日：2021-03-04

申请号：US17011880

申请日：2020-09-03

Applicant: Arcturus Therapeutics, Inc.

Inventor： Kumar RAJAPPAN ,  Padmanabh CHIVUKULA ,  Kiyoshi TACHIKAWA ,  Steven TANIS ,  Priya KARMALI

IPC: A61K47/54 ,  C07H15/04 ,  C12N15/113

Abstract: ASGP-R binding molecular conjugates are provided. The conjugates are useful to deliver therapeutically effective amounts of biologically active molecules to target cells and tissues of a subject. Compositions are also provided comprising the molecular conjugates.

公开(公告)号：US20230149310A1

公开(公告)日：2023-05-18

申请号：US17042848

申请日：2019-04-01

Applicant: Arcturus Therapeutics, Inc.

Inventor： Padmanabh CHIVUKULA ,  Priya KARMALI ,  Christine ESAU ,  Jerel VEGA ,  Yanjie BAO ,  Rajesh MUKTHAVARAM ,  Samantha MURPHY

IPC: A61K9/127 ,  A61K31/7105 ,  A61K31/711 ,  A61K39/12

CPC classification number: A61K9/1272 ,  A61K31/7105 ,  A61K31/711 ,  A61K39/12

Abstract: Nucleic acid immunization is achieved by delivering a nucleic acid (NA), e.g., a mRNA or a DNA, encapsulated within a lipid-NA nanoparticle. The NA encodes an immunogenic compound of interest. The lipid-NA nanoparticle is effective for in vivo delivery of NA to a vertebrate cell, including upon administration to a subject. The lipid-NA nanoparticle are incorporated in pharmaceutical compositions for immunizing subjects against various diseases.

公开(公告)号：US20200297634A1

公开(公告)日：2020-09-24

申请号：US16823212

申请日：2020-03-18

Applicant: Arcturus Therapeutics, Inc.

Inventor： Priya KARMALI ,  Padmanabh Chivukula ,  Joseph E. Payne ,  Yanjie Bao

IPC: A61K9/127 ,  A61K9/14 ,  A61K47/69 ,  A61K47/60

Abstract: A method of producing a lipid-encapsulated RNA nanoparticle, comprising the steps a) flowing an aqueous solution comprising an RNA through a 1st tube having an inner diameter (ID) of between about 0.1″ and 0.132″; b) flowing an ethanol solution comprising lipids through a 2nd tube having an ID of between about 0.005″ and 0.02″ at one third the flow rate of the aqueous solution through the 1st tube, wherein the lipids comprise a cationic lipid; and c) mixing the ethanol solution with the aqueous solution by flowing the ethanol solution and the aqueous solution into a mixing module consisting of the 2nd tube perpendicularly joined to the 1st tube; wherein the mixing produces an output solution flowing in the 1st tube comprising a turbulent flow of the RNA and the lipids in between about 10% to 75% ethanol v/v, and wherein the lipid-encapsulated RNA nanoparticles have a bilayer structure.

公开(公告)号：US20190388562A1

公开(公告)日：2019-12-26

申请号：US16527955

申请日：2019-07-31

Applicant: Arcturus Therapeutics, Inc.

Inventor： Joseph E. PAYNE ,  Padmanabh CHIVUKULA ,  Priya KARMALI ,  Steven P. TANIS

IPC: A61K48/00 ,  A61K47/20 ,  C07C333/04 ,  A61K9/51

Abstract: What is described is a compound of formula I consisting of a compound in which R1 is a branched chain alkyl consisting of 10 to 31 carbons; R2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons; L1 and L2 are the same or different, each a linear alkylene or alkenylene consisting of 2 to 20 carbons; X1 is S or O; R3 is a linear or branched alkylene consisting of 1 to 6 carbons; and R4 and R5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.