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公开(公告)号:US20210060168A1
公开(公告)日:2021-03-04
申请号:US17011880
申请日:2020-09-03
Applicant: Arcturus Therapeutics, Inc.
Inventor: Kumar RAJAPPAN , Padmanabh CHIVUKULA , Kiyoshi TACHIKAWA , Steven TANIS , Priya KARMALI
IPC: A61K47/54 , C07H15/04 , C12N15/113
Abstract: ASGP-R binding molecular conjugates are provided. The conjugates are useful to deliver therapeutically effective amounts of biologically active molecules to target cells and tissues of a subject. Compositions are also provided comprising the molecular conjugates.
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公开(公告)号:US20230149310A1
公开(公告)日:2023-05-18
申请号:US17042848
申请日:2019-04-01
Applicant: Arcturus Therapeutics, Inc.
Inventor: Padmanabh CHIVUKULA , Priya KARMALI , Christine ESAU , Jerel VEGA , Yanjie BAO , Rajesh MUKTHAVARAM , Samantha MURPHY
IPC: A61K9/127 , A61K31/7105 , A61K31/711 , A61K39/12
CPC classification number: A61K9/1272 , A61K31/7105 , A61K31/711 , A61K39/12
Abstract: Nucleic acid immunization is achieved by delivering a nucleic acid (NA), e.g., a mRNA or a DNA, encapsulated within a lipid-NA nanoparticle. The NA encodes an immunogenic compound of interest. The lipid-NA nanoparticle is effective for in vivo delivery of NA to a vertebrate cell, including upon administration to a subject. The lipid-NA nanoparticle are incorporated in pharmaceutical compositions for immunizing subjects against various diseases.
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公开(公告)号:US20200297634A1
公开(公告)日:2020-09-24
申请号:US16823212
申请日:2020-03-18
Applicant: Arcturus Therapeutics, Inc.
Inventor: Priya KARMALI , Padmanabh Chivukula , Joseph E. Payne , Yanjie Bao
Abstract: A method of producing a lipid-encapsulated RNA nanoparticle, comprising the steps a) flowing an aqueous solution comprising an RNA through a 1st tube having an inner diameter (ID) of between about 0.1″ and 0.132″; b) flowing an ethanol solution comprising lipids through a 2nd tube having an ID of between about 0.005″ and 0.02″ at one third the flow rate of the aqueous solution through the 1st tube, wherein the lipids comprise a cationic lipid; and c) mixing the ethanol solution with the aqueous solution by flowing the ethanol solution and the aqueous solution into a mixing module consisting of the 2nd tube perpendicularly joined to the 1st tube; wherein the mixing produces an output solution flowing in the 1st tube comprising a turbulent flow of the RNA and the lipids in between about 10% to 75% ethanol v/v, and wherein the lipid-encapsulated RNA nanoparticles have a bilayer structure.
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公开(公告)号:US20190388562A1
公开(公告)日:2019-12-26
申请号:US16527955
申请日:2019-07-31
Applicant: Arcturus Therapeutics, Inc.
Inventor: Joseph E. PAYNE , Padmanabh CHIVUKULA , Priya KARMALI , Steven P. TANIS
IPC: A61K48/00 , A61K47/20 , C07C333/04 , A61K9/51
Abstract: What is described is a compound of formula I consisting of a compound in which R1 is a branched chain alkyl consisting of 10 to 31 carbons; R2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons; L1 and L2 are the same or different, each a linear alkylene or alkenylene consisting of 2 to 20 carbons; X1 is S or O; R3 is a linear or branched alkylene consisting of 1 to 6 carbons; and R4 and R5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.
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