公开(公告)号：US20210060168A1

公开(公告)日：2021-03-04

申请号：US17011880

申请日：2020-09-03

Applicant: Arcturus Therapeutics, Inc.

Inventor： Kumar RAJAPPAN ,  Padmanabh CHIVUKULA ,  Kiyoshi TACHIKAWA ,  Steven TANIS ,  Priya KARMALI

IPC: A61K47/54 ,  C07H15/04 ,  C12N15/113

Abstract: ASGP-R binding molecular conjugates are provided. The conjugates are useful to deliver therapeutically effective amounts of biologically active molecules to target cells and tissues of a subject. Compositions are also provided comprising the molecular conjugates.

公开(公告)号：US20220389422A1

公开(公告)日：2022-12-08

申请号：US17737690

申请日：2022-05-05

Applicant: Arcturus Therapeutics, Inc.

Inventor： Kumar RAJAPPAN ,  Steven TANIS ,  Amit SAGI ,  Priya Prakash KARMALI

IPC: C12N15/113 ,  C07C327/34 ,  C07C229/24 ,  A61K9/127 ,  A61K9/19 ,  A61K9/51 ,  A61K47/14 ,  A61K9/00 ,  A61P37/02

Abstract: The present disclosure describes compounds of Formula (I) or a pharmaceutically acceptable salt thereof: wherein: R1 and R2 are each independently (CH3(CH2)m)2CH—, (CH3(CH2)m)(CH3(CH2)m-1)CH, (CH3(CH2)m)(CH3(CH2)m-2)CH, (CH3(CH2)m)2CHCH2—, or (CH3(CH2)m)(CH3(CH2)m-1)CHCH2—, wherein m is 4-11; L1 and L2 are each independently absent, a linear C1-5 alkylene, or (CH2)p—O—(CH2)q, wherein p and q are each independently 1-3; R3 is a linear C2-5 alkylene optionally substituted with one or two methyl groups; R4 and R5 are each independently H or C1-6 alkyl; X is O or S; and n is 0-2.

公开(公告)号：US20230295081A1

公开(公告)日：2023-09-21

申请号：US17985045

申请日：2022-11-10

Applicant: Arcturus Therapeutics, Inc.

Inventor： Kumar RAJAPPAN ,  Steven TANIS ,  Amit SAGI ,  Priya Prakash KARMALI ,  Padmanabh CHIVUKULA

IPC: C07C333/04 ,  C12N15/113 ,  C12N15/88 ,  C07C229/04 ,  C07C327/06 ,  C07C271/20 ,  C07C275/16 ,  C07C229/16 ,  A61K47/69 ,  A61K47/54

CPC classification number: C07C333/04 ,  A61K47/543 ,  A61K47/6911 ,  C07C229/04 ,  C07C229/16 ,  C07C271/20 ,  C07C275/16 ,  C07C327/06 ,  C12N15/88 ,  C12N15/113 ,  C07C2601/14 ,  C07C2602/22 ,  C07C2602/24 ,  C07C2602/28 ,  C12N2310/14

Abstract: The present disclosure describes compounds of Formula (I) and pharmaceutically acceptable salts thereof: