公开(公告)号：US20210223257A1

公开(公告)日：2021-07-22

申请号：US17249863

申请日：2021-03-16

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Stephen Albert JOHNSTON ,  Phillip STAFFORD ,  Jian ZHANG ,  Luhui SHEN

IPC: G01N33/68 ,  A61K39/00 ,  A61K45/06

Abstract: Disclosed herein are methods and systems for determining microsatellite instability. In some embodiments, the disclosed methods and systems are used for determining whether a cancer patient has high microsatellite instability (MSI-H). MSI-H patients have remarkably good responses to immunotherapy, such as checkpoint inhibitors immunotherapy. Therefore, the disclosed methods and systems can be used for identifying MSI-H and thus, patients as candidates for immunotherapy. In turn, the disclosed methods and systems can be used to predict responsiveness to immunotherapy. In some embodiments, the methods further include providing an immunotherapy to the MSI-H patient. Also disclosed are vaccines and compositions.

公开(公告)号：US20210196805A1

公开(公告)日：2021-07-01

申请号：US16617889

申请日：2018-06-01

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Stephen Albert JOHNSTON ,  Luhui SHEN

IPC: A61K39/00 ,  A61P35/00 ,  A61K39/39 ,  G01N33/574 ,  G01N33/50

Abstract: Provided herein, are methods of treating cancer in dogs using personalized cancer vaccines comprising peptides having frameshift mutations caused by errors in transcription and splicing of an mRNA.

公开(公告)号：US20230338486A1

公开(公告)日：2023-10-26

申请号：US18050806

申请日：2022-10-28

Applicant: Arizona Board of Regents on Behalf of Arizona State University

Inventor： Stephen Albert JOHNSTON ,  Luhui SHEN

IPC: A61K39/00 ,  A61P35/00 ,  A61K9/00 ,  A61K39/39 ,  G01N33/50 ,  G01N33/574

CPC classification number: A61K39/0011 ,  A61P35/00 ,  A61K9/0019 ,  A61K39/39 ,  G01N33/505 ,  G01N33/574 ,  G01N33/5011 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/552

Abstract: Provided herein, are methods of treating cancer in dogs using personalized cancer vaccines comprising peptides having frameshift mutations caused by errors in transcription and splicing of an mRNA.

公开(公告)号：US20220257701A1

公开(公告)日：2022-08-18

申请号：US17711849

申请日：2022-04-01

Applicant: Arizona Board of Regents on Behalf of Arizona State University

Inventor： Stephen Albert JOHNSTON ,  Luhui SHEN

IPC: A61K38/16 ,  A61P35/00 ,  A61K38/08 ,  A61K38/10 ,  G01N33/574 ,  C12N15/10 ,  A61K39/00

Abstract: Provided herein, are methods of identifying neoantigens for treating and preventing cancer. Also disclosed are methods and compositions for administering identified neoantigens for the treatment and prevention of cancer.

公开(公告)号：US20220251544A1

公开(公告)日：2022-08-11

申请号：US17706469

申请日：2022-03-28

Applicant: Arizona Board of Regents on Behalf of Arizona State University

Inventor： Stephen Albert JOHNSTON ,  Luhui SHEN

IPC: C12N15/10 ,  G01N33/574

Abstract: Provided herein, are methods of identifying neoantigens for treating and preventing cancer. Also disclosed are methods and compositions for administering identified neoantigens for the treatment and prevention of cancer.

公开(公告)号：US20200276285A1

公开(公告)日：2020-09-03

申请号：US16617805

申请日：2018-06-01

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Stephen Albert JOHNSTON ,  Luhui SHEN

IPC: A61K39/00 ,  G01N33/50 ,  A61K39/39 ,  A61K9/00 ,  G01N33/574 ,  A61P35/00

Abstract: Provided herein, are methods of treating cancer using personalized cancer vaccines comprising peptides having frameshift mutations caused by errors in transcription and splicing of an mRNA.