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公开(公告)号:US20170348310A1
公开(公告)日:2017-12-07
申请号:US15684733
申请日:2017-08-23
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor: James F. Blake , Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Michael Lyon , Andrew T. Metcalf , Peter J. Mohr , David A. Moreno , Brad Newhouse , Li Ren , Tony P. Tang , Allen A. Thomas , Jacob Schwarz , Jane Schmidt , Lewis Gazzard , Huifen Chen
IPC: A61K31/506 , C07D417/14 , C07D405/14 , C07D403/04 , A61K31/4439 , C07D401/14 , A61K45/06 , A61K31/444 , C07D471/04 , C07D403/14
CPC classification number: A61K31/506 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
Abstract: Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号:US09670208B2
公开(公告)日:2017-06-06
申请号:US15197445
申请日:2016-06-29
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor: James F. Blake , Adam Cook , John Gaudino , Indrani W. Gunawardana , Erik James Hicken , Kevin W. Hunt , Michael Lyon , Andrew T. Metcalf , Peter J. Mohr , David A. Moreno , Brad Newhouse , Li Ren , Jacob Schwarz , Huifen Chen , Lewis Gazzard , Jane Schmidt , Steve Do
IPC: C07D471/04 , A61K45/06 , A61K31/5377 , A61K31/506 , A61K31/444 , C07D487/04 , C07D519/00 , A61K31/55
CPC classification number: C07D471/04 , A61K31/444 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04 , C07D519/00
Abstract: Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.
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公开(公告)号:US20160304519A1
公开(公告)日:2016-10-20
申请号:US15197445
申请日:2016-06-29
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor: James F. Blake , Adam Cook , John Gaudino , Indrani W. Gunawardana , Erik James Hicken , Kevin W. Hunt , Michael Lyon , Andrew T. Metcalf , Peter J. Mohr , David A. Moreno , Brad Newhouse , Li Ren , Jacob Schwarz , Huifen Chen , Lewis Gazzard , Jane Schmidt , Steve Do
IPC: C07D471/04 , A61K31/5377 , A61K31/55 , A61K31/444 , C07D487/04 , C07D519/00 , A61K45/06 , A61K31/506
CPC classification number: C07D471/04 , A61K31/444 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04 , C07D519/00
Abstract: Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.
Abstract translation: 提供式I化合物或其立体异构体,互变异构体或其药学上可接受的盐,其可用于治疗疾病。 公开了使用式I化合物或其立体异构体,互变异构体或其药学上可接受的盐在体外,原位和体内诊断,预防或治疗这些疾病或相关病理状况的方法。
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公开(公告)号:US10154995B2
公开(公告)日:2018-12-18
申请号:US15684733
申请日:2017-08-23
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor: James F. Blake , Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Michael Lyon , Andrew T. Metcalf , Peter J. Mohr , David A. Moreno , Brad Newhouse , Li Ren , Tony P. Tang , Allen A. Thomas , Jacob Schwarz , Jane Schmidt , Lewis Gazzard , Huifen Chen
IPC: A61K31/506 , C07D417/14 , C07D405/14 , C07D403/04 , C07D401/14 , C07D471/04 , C07D403/14 , A61K31/4439 , A61K31/444 , A61K45/06
Abstract: Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号:US09763942B2
公开(公告)日:2017-09-19
申请号:US15197479
申请日:2016-06-29
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor: James F. Blake , Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Michael Lyon , Andrew T. Metcalf , Peter J. Mohr , David A. Moreno , Brad Newhouse , Li Ren , Tony P. Tang , Allen A. Thomas , Jacob Schwarz , Jane Schmidt , Lewis Gazzard , Huifen Chen
IPC: C07D403/14 , C07D471/04 , C07D417/14 , C07D403/04 , C07D401/14 , A61K31/506 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D405/14
CPC classification number: A61K31/506 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
Abstract: Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号:US20160303126A1
公开(公告)日:2016-10-20
申请号:US15197479
申请日:2016-06-29
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor: James F. Blake , Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Michael Lyon , Andrew T. Metcalf , Peter J. Mohr , David A. Moreno , Brad Newhouse , Li Ren , Tony P. Tang , Allen A. Thomas , Jacob Schwarz , Jane Schmidt , Lewis Gazzard , Huifen Chen
IPC: A61K31/506 , C07D403/14 , C07D471/04 , A61K31/4439 , C07D417/14 , C07D403/04 , C07D401/14 , A61K31/444 , A61K45/06 , C07D405/14
CPC classification number: A61K31/506 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
Abstract: Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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