-
公开(公告)号：US20160318877A1
公开(公告)日：2016-11-03
申请号：US15204715
申请日：2016-07-07
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： David Askin , Chong Han , Jonathan W. Lane , Travis Remarchuk , Sagar Shakya , C. Gregory Sowell , Keith L. Spencer , Peter J. Stengel
IPC: C07D239/42
CPC classification number: C07D239/42 , C07D239/30 , C07D239/70 , C07D403/04
Abstract: The invention provides processes for preparing a compound of formula I and salts thereof, wherein R1 is defined herein, and compounds and intermediates of said formula.
Abstract translation: 和其盐，其中R1如本文所定义，以及所述式的化合物和中间体。
-
公开(公告)号：US09416110B2
公开(公告)日：2016-08-16
申请号：US14401087
申请日：2013-05-17
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： David Askin , Chong Han , Jonathan W. Lane , Travis Remarchuk , Sagar Shakya , C. Gregory Sowell , Keith L. Spencer , Peter J. Stengel
IPC: C07D239/02 , C07D239/42 , C07D239/30 , C07D403/04 , C07D239/70
CPC classification number: C07D239/42 , C07D239/30 , C07D239/70 , C07D403/04
Abstract: The invention provides processes for preparing a compound of formula I and salts thereof, wherein R1 is defined herein, and compounds and intermediates of said formula.
Abstract translation: 本发明提供制备式I化合物及其盐的方法，其中R 1在本文中定义，以及所述式的化合物和中间体。
-
公开(公告)号：US09309204B2
公开(公告)日：2016-04-12
申请号：US14401091
申请日：2013-05-17
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： Jonathan W. Lane , Travis Remarchuk , Sagar Shakya , Keith L. Spencer , Peter J. Stengel
IPC: C07D403/04 , C07D239/70 , C07D239/42
CPC classification number: C07D239/70 , C07D239/42 , C07D403/04
Abstract: The invention provides new processes for making and purifying hydroxylated cyclopenta[d]pyrimidine compounds, which are useful for the treatment of diseases such as cancer as AKT protein kinase inhibitors, including the compound (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one.
Abstract translation: 本发明提供了用于制备和纯化羟基化环戊二烯并[d]嘧啶化合物的新方法，其可用于治疗诸如癌症的疾病作为AKT蛋白激酶抑制剂，包括化合物（S）-2-（4-氯苯基）-1 - （4 - （（5R，7R）-7-羟基-5-甲基-6,7-二氢-5H-环戊二烯并[d]嘧啶-4-基）哌嗪-1-基）-3-（异丙基氨基） -1。
-
公开(公告)号：US09790190B2
公开(公告)日：2017-10-17
申请号：US15593064
申请日：2017-05-11
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： David Askin , Chong Han , Jonathan W. Lane , Travis Remarchuk , Sagar Shakya , C. Gregory Sowell , Keith L. Spencer , Peter J. Stengel
IPC: C07D403/00 , C07D239/42 , C07D403/04
CPC classification number: C07D239/42 , C07D239/30 , C07D239/70 , C07D403/04
Abstract: The invention provides processes for preparing a compound of formula I and salts thereof, wherein R1 is defined herein, and compounds and intermediates of said formula.
-
公开(公告)号：US20150099881A1
公开(公告)日：2015-04-09
申请号：US14401091
申请日：2013-05-17
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： Jonathan W. Lane , Travis Remarchuk , Sagar Shakya , Keith L. Spencer , Peter J. Stengel
IPC: C07D239/70 , C07D239/42
CPC classification number: C07D239/70 , C07D239/42 , C07D403/04
Abstract: The invention provides new processes for making and purifying hydroxylated cyclopenta[d]pyrimidine compounds, which are useful for the treatment of diseases such as cancer as AKT protein kinase inhibitors, including the compound (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one.
Abstract translation: 本发明提供了用于制备和纯化羟基化环戊二烯并[d]嘧啶化合物的新方法，其可用于治疗诸如癌症的疾病作为AKT蛋白激酶抑制剂，包括化合物（S）-2-（4-氯苯基）-1 - （4 - （（5R，7R）-7-羟基-5-甲基-6,7-二氢-5H-环戊二烯并[d]嘧啶-4-基）哌嗪-1-基）-3-（异丙基氨基） -1。
-
Patent Agency Ranking
公开(公告)号：US20180258054A1
公开(公告)日：2018-09-13
申请号：US15782620
申请日：2017-10-12
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： David Askin , Chong Han , Jonathan W. Lane , Travis Remarchuk , Sagar Shakya , C. Gregory Sowell , Keith L. Spencer , Peter J. Stengel
IPC: C07D239/42 , C07D403/04
CPC classification number: C07D239/42 , C07D239/30 , C07D239/70 , C07D403/04
Abstract: The invention provides processes for preparing a compound of formula I and salts thereof, wherein R1 is defined herein, and compounds and intermediates of said formula.
-
公开(公告)号：US09676730B2
公开(公告)日：2017-06-13
申请号：US15204715
申请日：2016-07-07
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： David Askin , Chong Han , Jonathan W. Lane , Travis Remarchuk , Sagar Shakya , C. Gregory Sowell , Keith L. Spencer , Peter J. Stengel
IPC: C07D239/70 , C07D239/42 , C07D239/30 , C07D403/04
CPC classification number: C07D239/42 , C07D239/30 , C07D239/70 , C07D403/04
Abstract: The invention provides processes for preparing a compound of formula I and salts thereof, wherein R1 is defined herein, and compounds and intermediates of said formula.
-
公开(公告)号：US20170247337A1
公开(公告)日：2017-08-31
申请号：US15593064
申请日：2017-05-11
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： David Askin , Chong Han , Jonathan W. Lane , Travis Remarchuk , Sagar Shakya , C. Gregory Sowell , Keith L. Spencer , Peter J. Stengel
IPC: C07D239/42
CPC classification number: C07D239/42 , C07D239/30 , C07D239/70 , C07D403/04
Abstract: The invention provides processes for preparing a compound of formula I and salts thereof, wherein R1 is defined herein, and compounds and intermediates of said formula.
-
公开(公告)号：US20150152067A1
公开(公告)日：2015-06-04
申请号：US14401087
申请日：2013-05-17
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： David Askin , Chong Han , Jonathan W. Lane , Travis Remarchuk , Sagar Shakya , C. Gregory Sowell , Keith L. Spencer , Peter J. Stengel
IPC: C07D239/42 , C07D239/70
CPC classification number: C07D239/42 , C07D239/30 , C07D239/70 , C07D403/04
Abstract: The invention provides processes for preparing a compound of formula I and salts thereof, wherein R1 is defined herein, and compounds and intermediates of said formula.
Abstract translation: 本发明提供制备式I化合物及其盐的方法，其中R 1在本文中定义，以及所述式的化合物和中间体。
-
![Polymorphs of 2-(4-(2-(1-(isopropyl-3-methyl-1H-1,2,4,triazol-5-yl)-5,6-dihydrobenzo[f] imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide, methods of production, and pharmaceutical uses thereof](/abs-image/US/2016/11/01/US09481690B2/abs.jpg.150x150.jpg)
10.发明授权Polymorphs of 2-(4-(2-(1-(isopropyl-3-methyl-1H-1,2,4,triazol-5-yl)-5,6-dihydrobenzo[f] imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide, methods of production, and pharmaceutical uses thereof 有权2-（4-（2-（1-（异丙基-3-甲基-1H-1,2,4-三唑-5-基）-5,6-二氢苯并[f]咪唑并[1,2-d ] [1,4]氧氮杂-9-基）-1H-吡唑-1-基）-2-甲基丙酰胺，其制备方法及其药学用途公开(公告)号：US09481690B2
公开(公告)日：2016-11-01
申请号：US14991658
申请日：2016-01-08
Applicant: Genentech, Inc.
Inventor： Jeffrey Stults , Travis Remarchuk , Frederic St-Jean
IPC: C07D498/04 , A61K31/553 , C07D498/06 , A61K45/06
CPC classification number: C07D498/04 , A61K31/553 , A61K45/06 , C07B2200/13 , C07D498/06
Abstract: The present invention relates to crystalline polymorphs of (2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide (GDC-0032, taselisib), methods of use, and processes of preparing thereof.
Abstract translation: 本发明涉及（2-（4-（2-（1-异丙基-3-甲基-1H-1,2,4-三唑-5-基）-5,6-二氢苯并[f]咪唑并[ [1,2-d] [1,4]氧氮杂-9-基）-1H-吡唑-1-基）-2-甲基丙酰胺（GDC-0032，taselisib），使用方法及其制备方法。
-
-
-
-
-
-
-
-
-
Search Results
17
records
(took 0.01 seconds)
