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![Polymorphs of 2-(4-(2-(1-(isopropyl-3-methyl-1H-1,2,4,triazol-5-yl)-5,6-dihydrobenzo[f] imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide, methods of production, and pharmaceutical uses thereof](/abs-image/US/2016/11/01/US09481690B2/abs.jpg.150x150.jpg)
1.发明授权Polymorphs of 2-(4-(2-(1-(isopropyl-3-methyl-1H-1,2,4,triazol-5-yl)-5,6-dihydrobenzo[f] imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide, methods of production, and pharmaceutical uses thereof 有权2-（4-（2-（1-（异丙基-3-甲基-1H-1,2,4-三唑-5-基）-5,6-二氢苯并[f]咪唑并[1,2-d ] [1,4]氧氮杂-9-基）-1H-吡唑-1-基）-2-甲基丙酰胺，其制备方法及其药学用途公开(公告)号：US09481690B2
公开(公告)日：2016-11-01
申请号：US14991658
申请日：2016-01-08
Applicant: Genentech, Inc.
Inventor： Jeffrey Stults , Travis Remarchuk , Frederic St-Jean
IPC: C07D498/04 , A61K31/553 , C07D498/06 , A61K45/06
CPC classification number: C07D498/04 , A61K31/553 , A61K45/06 , C07B2200/13 , C07D498/06
Abstract: The present invention relates to crystalline polymorphs of (2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide (GDC-0032, taselisib), methods of use, and processes of preparing thereof.
Abstract translation: 本发明涉及（2-（4-（2-（1-异丙基-3-甲基-1H-1,2,4-三唑-5-基）-5,6-二氢苯并[f]咪唑并[ [1,2-d] [1,4]氧氮杂-9-基）-1H-吡唑-1-基）-2-甲基丙酰胺（GDC-0032，taselisib），使用方法及其制备方法。
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![POLYMORPHS OF 2-(4-(2-(1-ISOPROPYL-3-METHYL-1H-1,2,4-TRIAZOL-5-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)-1H-PYRAZOL-1-YL)-2-METHYLPROPANAMIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF](/abs-image/US/2016/08/04/US20160222027A1/abs.jpg.150x150.jpg)
公开(公告)号：US20160222027A1
公开(公告)日：2016-08-04
申请号：US14991658
申请日：2016-01-08
Applicant: Genentech, Inc.
Inventor： Jeffrey Stults , Travis Remarchuk , Frederic St-Jean
IPC: C07D498/04
CPC classification number: C07D498/04 , A61K31/553 , A61K45/06 , C07B2200/13 , C07D498/06
Abstract: The present invention relates to crystalline polymorphs of (2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide (GDC-0032, taselisib), methods of use, and processes of preparing thereof.
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公开(公告)号：US09303043B2
公开(公告)日：2016-04-05
申请号：US14205634
申请日：2014-03-12
Applicant: Genentech, Inc.
Inventor： Remy Angelaud , Danial R. Beaudry , Diane E. Carrera , Sushant Malhotra , Travis Remarchuk , Frederic St-Jean
IPC: C07D233/54 , C07D249/08 , C07D267/14 , C07D498/04
CPC classification number: C07D498/04
Abstract: Processes are described for the preparation of PI3K inhibitor, GDC-0032, Formula I, having the structure: and intermediates useful for the preparation of I.
Abstract translation: 描述了制备具有以下结构的PI3K抑制剂GDC-0032，式I的方法：和用于制备I的中间体。
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公开(公告)号：US20140275523A1
公开(公告)日：2014-09-18
申请号：US14205634
申请日：2014-03-12
Applicant: Genentech, Inc.
Inventor： Remy Angelaud , Danial R. Beaudry , Diane E. Carrera , Sushant Malhotra , Travis Remarchuk , Frederic St-Jean
IPC: C07D498/04
CPC classification number: C07D498/04
Abstract: Processes are described for the preparation of PI3K inhibitor, GDC-0032, Formula I, having the structure: and intermediates useful for the preparation of I.
Abstract translation: 描述了制备具有以下结构的PI3K抑制剂GDC-0032，式I的方法：和用于制备I的中间体。
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