利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

4 条记录 (耗时 0.019 秒)

    Anti-viral multi-quinone compounds and regiospecific synthesis thereof
    3.
    发明授权
    Anti-viral multi-quinone compounds and regiospecific synthesis thereof 失效
    抗病毒多醌化合物及其区域特异性合成

    公开(公告)号：US06828347B2

    公开(公告)日：2004-12-07

    申请号：US10288685

    申请日：2002-11-06

    申请人： Kenneth William Stagliano ,  Ashkan Emadi

    发明人： Kenneth William Stagliano ,  Ashkan Emadi

    IPC分类号： C07D30777

    CPC分类号： C07D311/92 ,  A61K31/12 ,  C07C46/00 ,  C07C50/08 ,  C07C50/24 ,  C07C50/30

    摘要： This invention provides various biquinone and trimeric quinone derivatives. The invention also provides a method for synthesis of a multi-quinone compound including reacting a hydroxyquinone anion with a first quinone possessing a first directing group at a C-2 of the first quinone and a second directing group at a C-3 of the first quinone and obtaining a biquinone having one of the first and second directing groups at a C-3 of a first quinone monomer and a hydroxyl group at a C-3′ of a second quinone monomer. The biquinone can be further reacted to obtain various biquinone derivatives or with a second hydroxyquinone anion to obtain trimeric quinone derivatives, including trimeric naphthoquinone derivatives. The biquinones and trimeric quinones of this invention demonstrate antiviral activity and can be used to treat viral infections, particularly HIV infections.

    摘要翻译： 本发明提供了各种双醌和三聚醌衍生物。 本发明还提供了一种合成多醌化合物的方法，包括使羟基醌阴离子与第一醌的C-2上具有第一定向基团的第一醌反应，第二定向基团在第一个醌的C-3处 醌，得到在第一醌单体的C-3和第二醌单体的C-3'的羟基上具有第一和第二导向基团之一的双醌。 可以进一步反应该双醌以获得各种双醌衍生物或第二羟基醌阴离子，得到三聚醌衍生物，包括三聚萘醌衍生物。 本发明的双醌和三聚醌表现出抗病毒活性，可用于治疗病毒感染，特别是HIV感染。