公开(公告)号：US20140221443A1

公开(公告)日：2014-08-07

申请号：US14152766

申请日：2014-01-10

Applicant: Astrazeneca AB ,  Array BioPharma Inc.

Inventor： John DeMattei ,  Tsung-Hsun Chuang ,  Gorkhn Sharma-Singh ,  Paul Alfred Dickinson ,  Mohammed Pervez ,  Richard Anthony Storey ,  Christopher John Squire ,  James Gair Ford ,  Ronald John Roberts

IPC: C07D235/08

CPC classification number: C07D235/08 ,  C07D235/06

Abstract: The present invention relates to Compound 1 hydrogen sulfate salt and solvates, crystalline forms and amorphous forms thereof, and to processes for their preparation.

Abstract translation: 本发明涉及化合物1硫酸氢盐和溶剂合物，其结晶形式和无定形形式，以及其制备方法。

公开(公告)号：US20160024018A1

公开(公告)日：2016-01-28

申请号：US14698151

申请日：2015-04-28

Applicant: Array BioPharma Inc. ,  ASTRAZENECA R&D ALDERLEY

Inventor： John DeMattei ,  Tsung-Hsun Chuang ,  Gorkhn Sharma-Singh ,  Paul Alfred Dickinson ,  Mohammed Pervez ,  Richard Anthony Storey ,  Christopher John Squire ,  James Gair Ford ,  Ronald John Roberts

IPC: C07D235/08

CPC classification number: C07D235/08 ,  C07D235/06

Abstract: The present invention relates to Compound 1 hydrogen sulfate salt and solvates, crystalline forms and amorphous forms thereof, and to processes for their preparation.

Abstract translation: 本发明涉及化合物1硫酸氢盐和溶剂合物，其结晶形式和无定形形式，以及其制备方法。

公开(公告)号：US09562017B2

公开(公告)日：2017-02-07

申请号：US14698151

申请日：2015-04-28

Applicant: Array BioPharma Inc. ,  ASTRAZENECA R&D ALDERLEY

Inventor： John DeMattei ,  Tsung-Hsun Chuang ,  Gorkhn Sharma-Singh ,  Paul Alfred Dickinson ,  Mohammed Pervez ,  Richard Anthony Storey ,  Christopher John Squire ,  James Gair Ford ,  Ronald John Roberts

IPC: C07D235/08 ,  C07D235/06

CPC classification number: C07D235/08 ,  C07D235/06

Abstract: The present invention relates to Compound 1 hydrogen sulfate salt and solvates, crystalline forms and amorphous forms thereof, and to processes for their preparation.

Abstract translation: 本发明涉及化合物1硫酸氢盐和溶剂合物，其结晶形式和无定形形式，以及其制备方法。 化合物I

公开(公告)号：US09815816B2

公开(公告)日：2017-11-14

申请号：US14805816

申请日：2015-07-22

Applicant: AstraZeneca AB

Inventor： Jorgen Blixt ,  Michael David Golden ,  Philip John Hogan ,  David Michael Glanville Martin ,  Francis Joseph Montgomery ,  Zakariya Patel ,  John David Pittam ,  George Joseph Sependa ,  Christopher John Squire ,  Nicholas Cartwright Alexander Wright

IPC: C07D401/12 ,  C07D211/16 ,  C07D239/94

CPC classification number: C07D401/12 ,  C07D211/16 ,  C07D239/94

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilizing said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.