公开(公告)号：US20240190811A1

公开(公告)日：2024-06-13

申请号：US18401080

申请日：2023-12-29

Applicant: DONGJIN SEMICHEM CO., LTD. ,  SAMSUNG DISPLAY CO., LTD.

Inventor： Ho Wan HAM ,  Hyun Cheol AN ,  Byung Cheol MIN ,  Hee Joo KIM ,  Dong Jun KIM ,  Hyung Jin LEE ,  Ja Eun ANN ,  Dong Yuel KWON ,  Yeong Rong PARK ,  Dae Woong LEE ,  Il Soo OH ,  Bo Ra LEE ,  Hyeon Jeong IM ,  Ill Hun CHO

IPC: C07C233/65 ,  C07C233/58 ,  C07C233/66 ,  C07C233/74 ,  C07C233/79 ,  C07C255/46 ,  C07C321/22 ,  C07D211/16 ,  C07D213/81 ,  C07D239/28 ,  C07D251/24 ,  C07D295/32 ,  C07F7/08 ,  H10K50/858

CPC classification number: C07C233/65 ,  C07C233/58 ,  C07C233/66 ,  C07C233/74 ,  C07C233/79 ,  C07C255/46 ,  C07C321/22 ,  C07D211/16 ,  C07D213/81 ,  C07D239/28 ,  C07D251/24 ,  C07D295/32 ,  C07F7/081 ,  H10K50/858 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/42 ,  C07C2602/44 ,  C07C2603/74

Abstract: A novel compound for a capping layer, and an organic light-emitting device containing the same are disclosed.

公开(公告)号：US20180297939A1

公开(公告)日：2018-10-18

申请号：US15925559

申请日：2018-03-19

Applicant: FORMA Therapeutics, Inc.

Inventor： Kenneth W. Bair ,  Nicholas Barczak ,  Bingsong Han ,  David R. Lancia, JR. ,  Cuixian Liu ,  Matthew W. Martin ,  Pui Yee Ng ,  Aleksandra Rudnitskaya ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Xiaozhang Zheng

IPC: C07C259/06 ,  C07D471/04 ,  C07D417/04 ,  C07D241/08 ,  C07D213/56 ,  C07D233/68 ,  C07D235/14 ,  C07D487/10 ,  C07D471/10 ,  C07D295/155 ,  C07D209/44 ,  A61K31/5377 ,  A61K31/4439 ,  A61K31/495 ,  A61K31/44 ,  A61K31/417 ,  A61K31/4184 ,  A61K31/397 ,  C07D495/10 ,  A61K31/407 ,  A61K31/435 ,  A61K31/451 ,  A61K31/4035 ,  A61K31/277 ,  A61K31/438 ,  C07D221/20 ,  A61K31/185 ,  C07D307/68 ,  C07D213/65 ,  C07D295/192 ,  C07D211/58 ,  C07D211/16 ,  C07D513/10 ,  C07D209/46 ,  C07D209/42 ,  C07D277/56 ,  C07D209/08 ,  C07D498/04 ,  C07D207/267 ,  C07D493/08 ,  C07D207/10 ,  C07D491/10 ,  C07D487/08 ,  C07D487/04 ,  C07D261/18 ,  C07D257/04 ,  C07D249/18 ,  C07D417/12 ,  C07D241/12 ,  C07D409/12 ,  C07D409/04 ,  C07D405/12 ,  C07D239/22 ,  C07D239/20 ,  C07D235/30 ,  C07D401/12 ,  C07D401/04 ,  C07D333/70 ,  C07D233/38 ,  C07D233/36 ,  C07D231/18 ,  C07D231/14 ,  C07D317/68 ,  C07D215/12 ,  C07D213/81 ,  C07D213/75 ,  C07D401/14

CPC classification number: C07C259/06 ,  A61K31/185 ,  A61K31/277 ,  A61K31/397 ,  A61K31/4035 ,  A61K31/407 ,  A61K31/417 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/438 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/451 ,  A61K31/495 ,  A61K31/5377 ,  C07D207/10 ,  C07D207/267 ,  C07D209/08 ,  C07D209/42 ,  C07D209/44 ,  C07D209/46 ,  C07D211/16 ,  C07D211/58 ,  C07D213/56 ,  C07D213/65 ,  C07D213/75 ,  C07D213/81 ,  C07D215/12 ,  C07D221/20 ,  C07D231/14 ,  C07D231/18 ,  C07D233/36 ,  C07D233/38 ,  C07D233/68 ,  C07D235/14 ,  C07D235/30 ,  C07D239/20 ,  C07D239/22 ,  C07D241/08 ,  C07D241/12 ,  C07D249/18 ,  C07D257/04 ,  C07D261/18 ,  C07D277/56 ,  C07D295/155 ,  C07D295/192 ,  C07D307/68 ,  C07D317/68 ,  C07D333/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D491/10 ,  C07D493/08 ,  C07D495/10 ,  C07D498/04 ,  C07D513/10 ,  Y02A50/393 ,  Y02A50/411 ,  Y02A50/481

Abstract: The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

公开(公告)号：US20180230120A1

公开(公告)日：2018-08-16

申请号：US15836261

申请日：2017-12-08

Applicant: Liming SHAO ,  Fengjiang WANG ,  Scott Christopher MALCOLM ,  Michael Charles HEWITT ,  Larry R. BUSH ,  Jianguo MA ,  Mark A. VARNEY ,  Una CAMPBELL ,  Sharon Rae ENGEL ,  Larry Wendell HARDY ,  Patrick KOCH ,  John E. CAMPELL

Inventor： Liming SHAO ,  Fengjiang WANG ,  Scott Christopher MALCOLM ,  Michael Charles HEWITT ,  Larry R. BUSH ,  Jianguo MA ,  Mark A. VARNEY ,  Una CAMPBELL ,  Sharon Rae ENGEL ,  Larry Wendell HARDY ,  Patrick KOCH ,  John E. CAMPELL

IPC: C07D333/20 ,  C07C211/17 ,  C07C211/29 ,  C07C215/42 ,  C07C215/44 ,  C07C217/52 ,  C07C217/74 ,  C07C323/32 ,  C07D207/06 ,  C07D207/08 ,  C07D211/14 ,  C07D265/14 ,  C07D277/28 ,  C07D295/06 ,  C07D307/52 ,  C07D317/58 ,  C07D317/72 ,  C07D319/06 ,  C07D491/056 ,  C07D211/16 ,  C07C211/40

CPC classification number: C07D333/20 ,  C07C211/17 ,  C07C211/29 ,  C07C211/40 ,  C07C215/42 ,  C07C215/44 ,  C07C217/52 ,  C07C217/74 ,  C07C323/32 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07D207/06 ,  C07D207/08 ,  C07D211/14 ,  C07D211/16 ,  C07D265/14 ,  C07D277/28 ,  C07D295/06 ,  C07D307/52 ,  C07D317/58 ,  C07D317/72 ,  C07D319/06 ,  C07D491/056

Abstract: The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

公开(公告)号：US20180208576A1

公开(公告)日：2018-07-26

申请号：US15745754

申请日：2016-07-07

Applicant: DSM IP ASSETS B.V.

Inventor： Stéphanie BOUDON ,  Piero GEOTTI-BIANCHINI ,  Marc HEIDL ,  Eileen JACKSON ,  Alexander SCHLIFKE-POSCHALKO

IPC: C07D401/10 ,  C07D265/30 ,  C07D223/04 ,  C07D211/16 ,  A61K8/49 ,  A61Q19/08

CPC classification number: C07D401/10 ,  A61K8/49 ,  A61K8/4906 ,  A61K8/4926 ,  A61Q19/08 ,  C07D211/16 ,  C07D223/04 ,  C07D265/30

Abstract: The present invention relates to novel selective 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and the use thereof to prevent age-induced skin structure and function defects.

公开(公告)号：US20180201577A1

公开(公告)日：2018-07-19

申请号：US15688185

申请日：2017-08-28

Applicant: Global Blood Therapeutics, Inc.

Inventor： Qing Xu ,  Zhe Li

IPC: C07D207/08 ,  C07D403/06 ,  C07C271/16 ,  C07D401/06 ,  C07D335/02 ,  C07D333/38 ,  C07D309/28 ,  C07D309/08 ,  C07D279/12 ,  C07D265/30 ,  C07D241/04 ,  C07D213/81 ,  C07D211/78 ,  C07D211/60 ,  C07D211/22 ,  C07D211/16 ,  C07D207/48 ,  C07D207/34 ,  C07D401/12

CPC classification number: C07D207/08 ,  C07C271/16 ,  C07D207/34 ,  C07D207/48 ,  C07D211/16 ,  C07D211/22 ,  C07D211/60 ,  C07D211/78 ,  C07D213/81 ,  C07D241/04 ,  C07D265/30 ,  C07D279/12 ,  C07D309/08 ,  C07D309/28 ,  C07D333/38 ,  C07D335/02 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06

Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

公开(公告)号：US10005731B2

公开(公告)日：2018-06-26

申请号：US14649585

申请日：2013-12-05

Applicant: Glaxo Group Limited

Inventor： Fangbin Han ,  Hui Lei ,  Xichen Lin ,  Qinghua Meng ,  Yonghui Wang

IPC: C07D211/16 ,  C07D403/12 ,  C07D401/14 ,  C07D413/14 ,  C07D401/12 ,  C07D407/12 ,  C07D241/04 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D405/12

CPC classification number: C07D211/16 ,  C07D241/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.

公开(公告)号：US09914702B2

公开(公告)日：2018-03-13

申请号：US15366513

申请日：2016-12-01

Applicant: Bionomics Limited ,  Merck Patent GmbH

Inventor： Andrew Harvey ,  Agnes Bombrun ,  Rachel Cooke ,  Isabelle Jeanclaude-Etter ,  Nathan Kuchel ,  Jerome Molette ,  Jorgen Mould ,  Dharam Paul ,  Rajinder Singh ,  Cristina Donini ,  Veronique Colovray ,  Thomas Avery ,  Julia Crossman ,  Justin Ripper

IPC: A61K31/497 ,  C07D213/40 ,  C07D309/14 ,  C07D213/89 ,  C07D231/12 ,  C07D233/56 ,  C07D401/12 ,  C07D237/08 ,  C07D239/24 ,  C07D405/12 ,  C07D411/12 ,  C07C217/90 ,  C07D413/12 ,  C07D241/12 ,  C07D209/52 ,  C07D211/16 ,  C07D211/26 ,  C07D211/38 ,  C07D213/16 ,  C07D213/61 ,  C07D213/64 ,  C07D213/70 ,  C07D241/18 ,  C07D451/04 ,  C07D239/34

CPC classification number: C07D213/40 ,  C07C217/90 ,  C07D209/52 ,  C07D211/16 ,  C07D211/26 ,  C07D211/38 ,  C07D213/16 ,  C07D213/61 ,  C07D213/64 ,  C07D213/70 ,  C07D213/89 ,  C07D231/12 ,  C07D233/56 ,  C07D237/08 ,  C07D239/24 ,  C07D239/34 ,  C07D241/12 ,  C07D241/18 ,  C07D309/14 ,  C07D401/12 ,  C07D405/12 ,  C07D411/12 ,  C07D413/12 ,  C07D451/04

Abstract: The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

公开(公告)号：US09884821B2

公开(公告)日：2018-02-06

申请号：US14766203

申请日：2014-02-06

Applicant: IMMUNOMET THERAPEUTICS INC.

Inventor： Chang Hee Min ,  Yong Eun Kim ,  Byung Kyu Oh ,  Ji Sun Lee ,  Hye Jin Heo ,  Ju Hoon Oh ,  Woong Cho

IPC: C07D207/20 ,  C07D211/14 ,  C07D211/70 ,  C07D211/16

CPC classification number: C07D211/70 ,  C07D207/20 ,  C07D211/14 ,  C07D211/16

Abstract: The present invention provides an N1-cyclic amine-N5-substituted biguanide derivative compound represented by Formula 1, a method of preparing the same and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient. The biguanide derivatives have an effect of inhibiting cancer cell proliferation, cancer metastasis and cancer recurrence by activation of AMPK, even when administered in a small dose compared with conventional drugs.

公开(公告)号：US09862693B2

公开(公告)日：2018-01-09

申请号：US14566055

申请日：2014-12-10

Applicant: The Regents of the University of California

Inventor： Richard J. Pietras ,  Michael E. Jung ,  Diana C. Marquez-Garban ,  Gang Deng

IPC: C07D295/215 ,  C07D203/20 ,  C07D211/16 ,  C07D213/78 ,  C07D239/28 ,  C07D401/12 ,  A61K31/155 ,  C07C279/26 ,  A61K31/4025 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  C07C279/22

CPC classification number: C07D295/215 ,  A61K31/155 ,  A61K31/4025 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  C07C279/22 ,  C07C279/26 ,  C07D203/20 ,  C07D211/16 ,  C07D213/78 ,  C07D239/28 ,  C07D401/12

Abstract: Presented herein inter alia are novel compounds and methods of using the same for the treatment of cancers.

公开(公告)号：US20170304237A1

公开(公告)日：2017-10-26

申请号：US15632422

申请日：2017-06-26

Applicant: National Institute of Biological Sciences, Beijing

Inventor： Zhiyuan Zhang ,  Xiaodong Wang ,  Yaning Su ,  Hanying Ruan ,  Yan Ren

IPC: A61K31/165 ,  C07D231/02 ,  C07C235/38 ,  A61K31/10 ,  C07C233/01 ,  A61K31/167 ,  C07D241/04 ,  C07D205/08

CPC classification number: A61K31/165 ,  A61K31/10 ,  A61K31/167 ,  C07C233/01 ,  C07C235/38 ,  C07D203/18 ,  C07D205/04 ,  C07D205/08 ,  C07D207/06 ,  C07D207/08 ,  C07D207/12 ,  C07D207/20 ,  C07D207/24 ,  C07D207/27 ,  C07D207/333 ,  C07D211/16 ,  C07D211/70 ,  C07D211/82 ,  C07D231/02 ,  C07D231/04 ,  C07D231/08 ,  C07D233/38 ,  C07D241/04 ,  C07D261/02 ,  C07D263/04 ,  C07D263/22 ,  C07D265/30 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04

Abstract: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.