公开(公告)号：US12110489B2

公开(公告)日：2024-10-08

申请号：US16954092

申请日：2018-12-18

Applicant: BASF SE

Inventor： Jared Dennis ,  Xuqiu Tan ,  Robin Cai

IPC: C12N15/10 ,  C12N1/20 ,  C12N15/70

CPC classification number: C12N15/1031 ,  C12N1/20 ,  C12N15/70 ,  C12N2800/101

Abstract: Disclosed herein is an improved Gene Site Saturation Mutagenesis (GSSM) method for producing a plurality of modified polynucleotides and/or polypeptides, creating specific changes to a gene, and reassembling mutations or changes at one or more sites.