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公开(公告)号：US11572356B2
公开(公告)日：2023-02-07
申请号：US17004411
申请日：2020-08-27
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , C07D417/14 , C07D495/04 , C07D409/14 , C07D401/14 , C07D513/04 , C07D413/14 , A61K31/506 , C07D239/30 , C07F5/02 , C07D417/12 , C07D487/04
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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公开(公告)号：US10577374B2
公开(公告)日：2020-03-03
申请号：US15698171
申请日：2017-09-07
Applicant: Sunesis Pharmaceuticals, Inc. , Biogen MA Inc.
Inventor： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC: C07D277/82 , C07D487/14 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04 , A61K31/519
Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
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公开(公告)号：US20200038385A1
公开(公告)日：2020-02-06
申请号：US16542746
申请日：2019-08-16
Applicant: BIOGEN MA INC.
Inventor： Jermaine Thomas , Sha Mi , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin Guckian , Gnanasambandam Kumaravel
IPC: A61K31/445 , C07K16/28 , A61K39/395 , A61K38/21 , A61K31/695 , A61K31/55 , A61K31/517 , A61K31/498 , A61K31/4709 , A61K31/4545 , A61K31/225 , C07D215/20 , C07D401/06 , C07D405/12 , C07D211/62 , C07D211/60 , C07D211/34
Abstract: Compounds of formula (I) or (II) can modulate the activity of S1P receptors.
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公开(公告)号：US20190218204A1
公开(公告)日：2019-07-18
申请号：US16108755
申请日：2018-08-22
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , C07F5/02 , C07D239/30 , A61K31/506 , C07D487/04 , C07D513/04 , C07D401/14 , C07D417/14 , C07D417/12 , C07D409/14 , C07D413/14 , C07D495/04
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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公开(公告)号：US10273234B2
公开(公告)日：2019-04-30
申请号：US14420020
申请日：2013-08-05
Applicant: BIOGEN MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Lihong Sun , Zhili Xin , Lei Zhang
IPC: C07D471/08 , A61K31/122 , C07C229/48 , C07D223/06 , C07D205/04 , C07D207/16 , C07D209/52 , C07D211/62 , A61K45/06 , A61K31/397 , A61K31/403 , A61K31/44 , A61K31/55 , A61K31/196 , A61K31/40 , A61K31/439 , A61K31/445 , C07C211/38 , C07D207/08
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
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Patent Agency Ranking
公开(公告)号：US10144732B2
公开(公告)日：2018-12-04
申请号：US15316534
申请日：2015-06-05
Applicant: BIOGEN MA INC.
Inventor： Gnanasambandam Kumaravel , Hairuo Peng , Zhili Xin
IPC: C07D471/04 , C07D487/04 , C07D519/00
Abstract: Compounds of formula (I) can modulate the activity of autotaxin (ATX).
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公开(公告)号：US10081619B2
公开(公告)日：2018-09-25
申请号：US15699857
申请日：2017-09-08
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , C07D487/04 , C07D401/14 , C07D413/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04
CPC classification number: C07D403/12 , A61K31/506 , C07D239/30 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04 , C07D513/04 , C07F5/027
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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公开(公告)号：US20180093973A1
公开(公告)日：2018-04-05
申请号：US15699857
申请日：2017-12-20
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , C07D487/04 , C07D401/14 , C07D413/14 , C07D409/14 , C07D417/14 , C07D495/04 , C07D513/04 , C07D417/12
CPC classification number: C07D403/12 , A61K31/506 , C07D239/30 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04 , C07D513/04 , C07F5/027
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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公开(公告)号：US20170197960A1
公开(公告)日：2017-07-13
申请号：US15316534
申请日：2015-06-05
Applicant: BIOGEN MA INC.
Inventor： Gnanasambandam Kumaravel , Hairuo Peng , Zhili Xin
IPC: C07D471/04 , C07D519/00
CPC classification number: C07D471/04 , C07D487/04 , C07D519/00
Abstract: Compounds of formula (I) can modulate the activity of autotaxin (ATX).
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10.发明授权公开(公告)号：US09499485B2
公开(公告)日：2016-11-22
申请号：US14420025
申请日：2013-08-05
Applicant: BIOGEN MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Lihong Sun , Zhili Xin , Lei Zhang
IPC: C07D451/02 , C07D211/62 , A61K31/122 , A61K45/06 , A61K31/192 , A61K31/216 , A61K31/439 , A61K31/445 , A61K31/45 , C07C229/14 , C07C229/48 , C07D211/60 , A61K31/196 , A61K31/197 , A61K31/198 , A61K31/46 , C07D211/34 , C07D451/14
CPC classification number: C07D211/62 , A61K31/122 , A61K31/192 , A61K31/196 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/439 , A61K31/445 , A61K31/45 , A61K31/46 , A61K45/06 , C07C229/14 , C07C229/48 , C07C2601/14 , C07D211/34 , C07D211/60 , C07D451/02 , C07D451/14 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
Abstract translation: 式（I）化合物可以调节一种或多种SIP受体的活性和/或自分泌素（ATX）的活性。
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