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1.发明申请PRODRUGS OF A PIPERIDINYL DERIVATIVE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 审中-公开哌啶衍生物作为化合物受体活性调节剂的产物公开(公告)号：US20130178444A1
公开(公告)日：2013-07-11
申请号：US13785039
申请日：2013-03-05
Applicant: Bristol-Myers Squibb Company
Inventor： John Hynes , Percy H. Carter , Lyndon A.M. Cornelius , T.G. Murali Dhar , John V. Duncia , Satheesh K. Nair , Joseph B. Santella , Jayakumar S. Warrier , Hong Wu
IPC: C07D211/60 , C07F9/59
CPC classification number: C07D211/60 , C07D211/52 , C07F9/59
Abstract: The present application describes prodrugs of the compound of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis using the prodrug compounds of the invention are disclosed.
Abstract translation: 本申请描述了式（I）化合物的前药或其立体异构体或其药学上可接受的盐。 此外，公开了使用本发明的前药化合物治疗和预防炎症性疾病如哮喘和过敏性疾病以及自身免疫性病症如类风湿性关节炎的方法。
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![Phosphoramidic acid prodrugs of 5-[5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl] pyridine-3-sulfonamide](/abs-image/US/2016/01/19/US09238666B2/abs.jpg.150x150.jpg)
2.发明授权Phosphoramidic acid prodrugs of 5-[5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl] pyridine-3-sulfonamide 有权5- [5-苯基-4-（吡啶-2-基甲基氨基）喹唑啉-2-基]吡啶-3-磺酰胺的磷酰胺酸前药公开(公告)号：US09238666B2
公开(公告)日：2016-01-19
申请号：US14406543
申请日：2013-06-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jayakumar S. Warrier , Navnath Dnyanoba Yadav
IPC: C07F9/6512 , C07D401/14 , C07F9/6558 , A61K31/675
CPC classification number: C07F9/65128 , A61K31/675 , C07D401/14 , C07F9/65583
Abstract: A compound of structural formula (I), wherein R is H or —PO3H or a pharmaceutically acceptable salt form thereof. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
Abstract translation: 结构式（I）的化合物，其中R是H或-PO 3 H或其药学上可接受的盐形式。 这些化合物可用作钾通道功能的抑制剂和治疗和预防心律失常，IKur相关疾病以及由离子通道功能介导的其它病症。
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![PHOSPHORAMIDIC ACID PRODRUGS OF 5-[5-PHENYL-4-(PYRIDIN-2-YLMETHYLAMINO)QUINAZOLIN-2-YL]PYRIDINE-3-SULFONAMIDE](/abs-image/US/2015/06/25/US20150175641A1/abs.jpg.150x150.jpg)
3.发明申请PHOSPHORAMIDIC ACID PRODRUGS OF 5-[5-PHENYL-4-(PYRIDIN-2-YLMETHYLAMINO)QUINAZOLIN-2-YL]PYRIDINE-3-SULFONAMIDE 有权5- [5-苯基-4-（吡啶-2-基]甲基氨基）喹唑啉-2-基]吡啶-3-磺酰胺的磷酸酰亚胺公开(公告)号：US20150175641A1
公开(公告)日：2015-06-25
申请号：US14406543
申请日：2013-06-10
Applicant: Bristol-Myers Squibb Company
Inventor： Jayakumar S. Warrier , Navnath Dnyanoba Yadav
IPC: C07F9/6512 , A61K31/675
CPC classification number: C07F9/65128 , A61K31/675 , C07D401/14 , C07F9/65583
Abstract: A compound of structural formula (I), wherein R is H or —PO3H or a pharmaceutically acceptable salt form thereof. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur associated disorders, and other disorders mediated by ion channel function.
Abstract translation: 结构式（I）的化合物，其中R是H或-PO 3 H或其药学上可接受的盐形式。 该化合物可用作钾通道功能的抑制剂和用于治疗和预防心律失常，IKur相关疾病以及由离子通道功能介导的其它病症。
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