摘要:
Intermediates useful in the preparation of compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein A, R1, R2, R3, , p, q, and X are as defined in the specification.
摘要:
Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein A, R1, R2, R3, p, q, A and X are as defined in the specification. Preparation of the compounds and uses in the treatment of CNS and other disorders, including depression and anxiety, are also disclosed.
摘要:
Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression or anxiety, are also disclosed.
摘要翻译:提供式(I)化合物及其药学上可接受的盐:其中R 1,m,X,R 2,n,W,p,Y,Z,R R 3,R 4,R 5和q具有如说明书中定义的含义。 还公开了其治疗方法及其在治疗中的用途,特别是CNS疾病如抑郁或焦虑症。
摘要:
Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression or anxiety, are also disclosed.
摘要翻译:提供式(I)化合物及其药学上可接受的盐:其中R 1,m,X,R 2,n,W,p,Y,Z,R R 3,R 4,R 5和q具有如说明书中所定义的含义。 还公开了其治疗方法及其在治疗中的用途,特别是CNS疾病如抑郁或焦虑症。
摘要:
The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.