摘要:
Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein A, R1, R2, R3, p, q, A and X are as defined in the specification. Preparation of the compounds and uses in the treatment of CNS and other disorders, including depression and anxiety, are also disclosed.
摘要:
Intermediates useful in the preparation of compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein A, R1, R2, R3, , p, q, and X are as defined in the specification.
摘要:
The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.
摘要:
Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression or anxiety, are also disclosed.
摘要翻译:提供式(I)化合物及其药学上可接受的盐:其中R 1,m,X,R 2,n,W,p,Y,Z,R R 3,R 4,R 5和q具有如说明书中定义的含义。 还公开了其治疗方法及其在治疗中的用途,特别是CNS疾病如抑郁或焦虑症。
摘要:
Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression or anxiety, are also disclosed.
摘要翻译:提供式(I)化合物及其药学上可接受的盐:其中R 1,m,X,R 2,n,W,p,Y,Z,R R 3,R 4,R 5和q具有如说明书中所定义的含义。 还公开了其治疗方法及其在治疗中的用途,特别是CNS疾病如抑郁或焦虑症。