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公开(公告)号：US10077265B2
公开(公告)日：2018-09-18
申请号：US15513853
申请日：2015-09-22
发明人： Susanne Röhrig , Alexander Hillisch , Julia Straβburger , Stefan Heitmeier , Martina Victoria Schmidt , Karl-Heinz Schlemmer , Adrian Tersteegen , Anja Buchmüller , Christoph Gerdes , Martina Schäfer , Henrik Teller , Eloisa Jiménez Núnez , Hartmut Schirok , Jürgen Klar , Mario Lobell
IPC分类号： C07D471/04 , A61K31/435 , A61K31/437 , A61P7/02
CPC分类号： C07D471/04
摘要： The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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公开(公告)号：US09918969B2
公开(公告)日：2018-03-20
申请号：US15332893
申请日：2016-10-24
发明人： Susanne Röhrig , Alexander Hillisch , Julia Straβburger , Stefan Heitmeier , Martina Victoria Schmidt , Karl-Heinz Schlemmer , Anja Buchmüller , Christoph Gerdes , Henrik Teller , Martina Schäfer , Adrian Tersteegen
IPC分类号： A61K31/438 , A61K31/437 , C07D215/227 , C07D221/04 , C07D401/12 , C07D413/12 , C07D471/04
CPC分类号： A61K31/438 , A61K31/437 , C07D215/227 , C07D221/04 , C07D401/12 , C07D413/12 , C07D471/04
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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3.发明授权Substituted oxopyridine derivatives and use thereof in the treatment of cardiovascular disorders 有权取代的氧代吡啶衍生物及其在治疗心血管疾病中的用途公开(公告)号：US09434690B2
公开(公告)日：2016-09-06
申请号：US14780925
申请日：2014-03-27
发明人： Susanne Röhrig , Alexander Hillisch , Julia Straβburger , Stefan Heitmeier , Martina Victoria Schmidt , Karl-Heinz Schlemmer , Adrian Tersteegen , Anja Buchmüller , Christoph Gerdes , Martina Schäfer , Tom Kinzel , Henrik Teller , Hartmut Schirok , Jürgen Klar , Eloisa Jimenez Nunez
IPC分类号： C07D213/64 , C07D401/12 , A61K31/4412 , C07D413/14 , C07D213/85 , C07D405/06 , C07D409/06 , C07D413/12 , C07D417/12 , C07D213/69 , C07D213/84
CPC分类号： C07D405/06 , C07B2200/05 , C07D213/64 , C07D213/69 , C07D213/84 , C07D213/85 , C07D401/12 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及眼药水以及眼科疾病的药物的用途 。
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公开(公告)号：US09783614B2
公开(公告)日：2017-10-10
申请号：US14400281
申请日：2013-05-08
发明人： Andreas Wilmen , Julia Straβburger , Frank Dittmer , Michael Strerath , Anja Buchmüller , Joanna Grudzinska-Goebel , Ricarda Finnern , Martina Schäfer , Christoph Gerdes , Hannah Jöriβen , Asako Itakura , Philberta Leung , Erik Tucker
CPC分类号： C07K16/36 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： The present invention relates to antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and methods of use thereof, particularly methods of use as agents inhibiting platelet aggregation and by this inhibits thrombus formation.
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5.发明授权Substituted oxopyridine derivatives and use thereof as factor xia/plasma 有权取代的氧代吡啶衍生物及其作为因子xia /等离子体的用途公开(公告)号：US09475809B2
公开(公告)日：2016-10-25
申请号：US14906771
申请日：2014-07-21
发明人： Susanne Röhrig , Alexander Hillisch , Julia Straβburger , Stefan Heitmeier , Martina Victoria Schmidt , Karl-Heinz Schlemmer , Anja Buchmüller , Christoph Gerdes , Henrik Teller , Martina Schäfer , Adrian Tersteegen
IPC分类号： C07D471/04 , C07D401/12 , C07D221/04 , C07D413/12 , C07D215/227
CPC分类号： A61K31/438 , A61K31/437 , C07D215/227 , C07D221/04 , C07D401/12 , C07D413/12 , C07D471/04
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及眼药水以及眼科疾病的药物的用途 。
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