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公开(公告)号:US20190209550A1
公开(公告)日:2019-07-11
申请号:US16307632
申请日:2017-06-28
发明人: Jie CHEN , Nicholas A. MEANWELL , Alicia REGUEIRO-REN , Sing-Yuen SIT , Jacob SWIDORSKI , Yan CHEN
IPC分类号: A61K31/4725 , A61K31/5365 , A61K45/06 , A61K31/496 , C07D217/06 , A61K31/541 , A61K31/53 , C07D417/14 , C07D401/12 , C07D417/12 , C07D471/04 , C07D473/28 , A61K31/522 , C07D405/12 , C07D487/04 , C07D495/04 , C07D401/14 , C07D413/12 , C07D407/12 , C07D471/08 , C07D487/08 , C07D453/00 , A61K31/4748 , C07D491/056 , A61P31/18
CPC分类号: A61K31/4725 , A61K31/4748 , A61K31/496 , A61K31/522 , A61K31/53 , A61K31/5365 , A61K31/541 , A61K45/06 , A61P31/18 , C07D217/06 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/06 , C07D409/14 , C07D413/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D453/00 , C07D471/04 , C07D471/08 , C07D473/28 , C07D487/04 , C07D487/08 , C07D491/056 , C07D495/04
摘要: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, azadecaline derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
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公开(公告)号:US20190160063A1
公开(公告)日:2019-05-30
申请号:US16066572
申请日:2016-12-30
发明人: Erkan Baloglu
IPC分类号: A61K31/506 , A61P35/00
CPC分类号: A61K31/506 , A61P35/00 , C07D239/26 , C07D241/12 , C07D401/08 , C07D401/12 , C07D403/06 , C07D403/08 , C07D403/12 , C07D409/06 , C07D413/06
摘要: The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula (I) or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.
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3.
公开(公告)号:US20190135754A1
公开(公告)日:2019-05-09
申请号:US16177926
申请日:2018-11-01
申请人: Brian M. Stoltz , Aurapat Ngamnithiporn , Carina I. Jette , Shoshana Bachman , Scott C. Virgil , Sebastian Lackner
发明人: Brian M. Stoltz , Aurapat Ngamnithiporn , Carina I. Jette , Shoshana Bachman , Scott C. Virgil , Sebastian Lackner
IPC分类号: C07D211/86 , B01J31/24 , C07D309/32
CPC分类号: C07D211/86 , B01J31/2409 , B01J2231/4272 , B01J2531/004 , B01J2531/847 , C07B37/04 , C07B2200/07 , C07D211/76 , C07D309/30 , C07D309/32 , C07D407/06 , C07D409/06
摘要: The present disclosure provides methods for enantioselective synthesis of cyclic and acyclic α-quaternary carboxylic acid derivatives via nickel-catalyzed allylic alkylation.
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4.
公开(公告)号:US20190092744A1
公开(公告)日:2019-03-28
申请号:US16083879
申请日:2017-01-20
申请人: SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES , HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
发明人: Xin CAO , Biao YU , Ning WANG , Junwei CHEN
IPC分类号: C07D335/06 , A61P35/04 , C07D409/10 , C07C69/84 , C07C69/78 , C07C63/70 , C07D239/28 , C07C229/56 , C07D213/84 , C07D213/79 , A61P35/00
CPC分类号: C07D335/06 , A61P35/00 , A61P35/02 , A61P35/04 , C07C63/70 , C07C67/343 , C07C69/76 , C07C69/78 , C07C69/84 , C07C229/56 , C07C233/54 , C07C2602/10 , C07D213/79 , C07D213/84 , C07D213/85 , C07D239/28 , C07D241/24 , C07D409/06 , C07D409/10
摘要: Disclosed are a retinoid compound, a preparation method therefor, intermediates thereof and an application thereof. The retinoid compound I of the present invention has a good tumor growth inhibition rate.
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公开(公告)号:US20190031607A1
公开(公告)日:2019-01-31
申请号:US16150070
申请日:2018-10-02
发明人: Jean-Christophe ANDREZ , Philippe BERGERON , Paul Robert BICHLER , Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Thilo FOCKEN , Wei GONG , Michael Edward GRIMWOOD , Abid HASAN , Ivan William HEMEON , Qi JIA , Brian Salvatore SAFINA , Shaoyi SUN , Michael Scott WILSON , Alla Yurevna ZENOVA
IPC分类号: C07D207/16 , C07C235/52 , C07D209/02 , C07D401/10 , C07D205/04 , C07D207/22 , C07D211/20 , C07C235/42 , C07D211/38 , C07D409/06 , C07D265/30 , C07D413/12 , C07D263/26 , C07C235/54 , C07D417/12 , C07D305/08 , C07D213/69 , C07D403/04 , C07D231/06 , C07D209/52 , C07D221/22 , C07D209/54 , C07D403/12 , C07D211/60 , C07D207/10 , C07D401/12 , C07D471/08 , C07D413/14 , C07D207/08 , C07D405/10 , C07D403/14 , C07D451/02 , C07D401/14 , C07D263/04 , C07D277/06
CPC分类号: C07D207/16 , C07C235/42 , C07C235/52 , C07C235/54 , C07C2601/02 , C07C2601/04 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/02 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D221/22 , C07D231/06 , C07D263/04 , C07D263/26 , C07D265/30 , C07D277/06 , C07D305/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/10 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/02 , C07D471/08
摘要: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号:US20190021327A1
公开(公告)日:2019-01-24
申请号:US16069242
申请日:2017-01-12
发明人: Rachel BALTZ , David BERNIER , Florence JAY-BRIOUDES , Thomas KNOBLOCH , Maxime VITEL , Olivier VOINNET
IPC分类号: A01N43/80 , A01G7/06 , C07D261/12 , C07D409/06
CPC分类号: A01N43/80 , A01G7/06 , A01G17/02 , A01G22/05 , A01G22/50 , A01G22/60 , A01G23/00 , C07D261/12 , C07D409/06
摘要: The present invention relates to the use of specific active substances, alone or in combination, for controlling virus infections in plants and to a method for using said specific active substances for controlling said virus infections in the field of plant protection and the protection of materials.
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公开(公告)号:US20180346448A1
公开(公告)日:2018-12-06
申请号:US16001883
申请日:2018-06-06
发明人: Venkataiah Bollu , James Breitenbucher , Alan Kaplan , Robert Lemus , Andrew Lindstrom , Troy Vickers , Michael Weinhouse , Mark E. Wilson , James Zapf
IPC分类号: C07D403/06 , C07D409/14 , C07D409/06 , C07D413/06 , C07D405/14 , C07D401/06 , C07D405/12 , C07D401/14 , C07D241/18 , A61K51/04 , C07D213/81 , C07D213/74 , C07D213/73 , C07D213/64 , C07D239/34 , C07D417/06
CPC分类号: C07D403/06 , A61K51/0459 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/81 , C07D239/34 , C07D241/18 , C07D401/06 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06
摘要: The invention provides a chemical entity of Formula (I), and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting PDE4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating treating peripheral disorders, including inflammatory and renal disorders.
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公开(公告)号:US20180312524A1
公开(公告)日:2018-11-01
申请号:US16029166
申请日:2018-07-06
发明人: Kenneth W. Bair , Torsten Herbertz , Goss S. Kauffman , Katherine J. Kayser-Bricker , George P. Luke , Matthew W. Martin , David S. Millan , Shawn E.R. Schiller , Adam C. Talbot , Mark J. Tebbe
IPC分类号: C07D498/04 , C07D413/14 , C07D409/12 , C07D241/50 , A61K31/541 , C07D403/10 , A61K31/517 , A61K31/55 , C07D417/06 , C07D401/14 , C07D417/10 , C07D405/14 , C07D401/12 , C07D487/04 , C07D413/12 , A61K31/553 , C07D487/08 , C07D491/048 , C07D417/04 , C07D413/04 , C07D401/10 , A61K31/519 , C07D409/06 , A61K31/506 , A61K31/5025 , A61K31/53 , C07D471/04 , C07D403/06 , C07D417/14 , A61K31/4985 , C07D413/06 , A61K31/551 , C07D451/04 , A61K31/498 , C07D405/10 , C07D401/04 , C07D241/42 , A61K31/5377 , C07D409/14 , C07D403/04 , C07D403/14 , C07D401/06 , C07D405/12 , C07D403/12 , C07D405/06 , A61K45/06 , C07D495/04 , C07D405/04
CPC分类号: C07D498/04 , A61K31/498 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/553 , A61K45/06 , C07D241/42 , C07D241/50 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/048 , C07D495/04 , A61K2300/00
摘要: The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R1, R2, R4 and R7 are defined herein.
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公开(公告)号:US20180312462A1
公开(公告)日:2018-11-01
申请号:US15763807
申请日:2016-09-30
发明人: Ying SHI , Yi MI , Hanyu YANG , Xuliang WANG , Denghuang GONG , Min BAI , Xiaozhuo CHEN , Yujie CHEN , Xuejiao ZHANG , Yuxiu MA , Qingzhi GAO
IPC分类号: C07C235/84 , C07D237/24 , C07D401/06 , C07D213/82 , C07D213/81 , C07C231/12 , C07D211/16 , C07D211/46 , C07D295/192 , C07C237/38 , C07C237/42 , C07C275/38 , C07C273/18 , C07D277/82 , C07D333/38 , C07D409/06 , C07D403/12 , C07D401/12
CPC分类号: C07C235/84 , A61K31/44 , A61K31/50 , C07C231/12 , C07C237/38 , C07C237/42 , C07C273/1854 , C07C275/38 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D211/16 , C07D211/46 , C07D213/81 , C07D213/82 , C07D237/24 , C07D277/82 , C07D295/192 , C07D333/38 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/06
摘要: The present invention relates to a benzamide derivative of general formula I, a drug composition containing same and a use thereof as a drug, wherein the definitions of R1, Z and Q are as described in the description.
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公开(公告)号:US20180305345A1
公开(公告)日:2018-10-25
申请号:US15542480
申请日:2016-01-26
发明人: Jean-Simon Diallo , Christopher Noyce Boddy , Mark Dornan , Ramya Krishnan , Fabrice Le Boeuf , John C. Bell , Andrew Macklin , Jeffrey Smith
IPC分类号: C07D413/06 , C07D207/38 , C07D207/456 , C07D209/48 , C07D231/08 , C07D237/14 , C07D307/58 , C07D307/60 , C07D307/66 , C07D317/64 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D409/06 , C07D471/04 , A61P35/02
CPC分类号: C07D413/06 , A61K31/341 , A61K31/4015 , A61K31/402 , A61K2300/00 , A61P35/02 , C07D207/36 , C07D207/38 , C07D207/456 , C07D209/48 , C07D231/08 , C07D237/14 , C07D307/30 , C07D307/58 , C07D307/60 , C07D307/66 , C07D317/64 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/06 , C07D417/06 , C07D471/04 , C12N7/00 , C12N2710/10334 , C12N2710/10351 , C12N2710/10352 , C12N2710/16651 , C12N2710/24151 , C12N2750/14151 , C12N2760/16134 , C12N2760/16151 , C12N2760/16152 , C12N2760/20234 , C12N2760/20251 , C12N2760/20252
摘要: Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the cytotoxicity of virus to cells. Other uses, compositions and methods of using same are also provided.
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