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公开(公告)号：US10071995B2
公开(公告)日：2018-09-11
申请号：US15513930
申请日：2015-09-22
发明人： Susanne Röhrig , Eloisa Jimenez Núnez , Karl-Heinz Schlemmer , Adrian Tersteegen , Henrik Teller , Alexander Hillisch , Stefan Heitmeier , Martina Victoria Schmidt , Jan Stampfuß
IPC分类号： C07D413/14 , C07D409/12 , C07D409/14 , A61P27/02 , A61P1/00 , A61P29/00
CPC分类号： C07D413/14 , A61P1/00 , A61P27/02 , A61P29/00 , C07D409/12 , C07D409/14
摘要： The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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2.发明授权Substituted oxopyridine derivatives and use thereof as factor xia/plasma 有权取代的氧代吡啶衍生物及其作为因子xia /等离子体的用途公开(公告)号：US09475809B2
公开(公告)日：2016-10-25
申请号：US14906771
申请日：2014-07-21
发明人： Susanne Röhrig , Alexander Hillisch , Julia Straβburger , Stefan Heitmeier , Martina Victoria Schmidt , Karl-Heinz Schlemmer , Anja Buchmüller , Christoph Gerdes , Henrik Teller , Martina Schäfer , Adrian Tersteegen
IPC分类号： C07D471/04 , C07D401/12 , C07D221/04 , C07D413/12 , C07D215/227
CPC分类号： A61K31/438 , A61K31/437 , C07D215/227 , C07D221/04 , C07D401/12 , C07D413/12 , C07D471/04
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及眼药水以及眼科疾病的药物的用途 。
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公开(公告)号：US11180471B2
公开(公告)日：2021-11-23
申请号：US16535120
申请日：2019-08-08
发明人： Eloisa Jimenez Nunez , Jens Ackerstaff , Susanne Roehrig , Alexander Hillisch , Katharina Meier , Stefan Heitmeier , Adrian Tersteegen , Jan Stampfuss , Pascal Ellerbrock , Daniel Meibom , Dieter Lang
IPC分类号： A61K31/4439 , A61P7/02 , C07D401/10 , C07D401/14 , C07D413/14 , C07D413/10
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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公开(公告)号：US10183932B2
公开(公告)日：2019-01-22
申请号：US15786352
申请日：2017-10-17
发明人： Susanne Röhrig , Alexander Hillisch , Julia Strassburger , Stefan Heitmeier , Martina Victoria Schmidt , Karl-Heinz Schlemmer , Adrian Tersteegen , Anja Buchmüller , Christoph Gerdes , Martina Schäfer , Tom Kinzel , Henrik Teller , Hartmut Schirok , Jürgen Klar , Eloisa Jimenez Nunez
IPC分类号： C07D213/84 , C07D405/06 , C07D413/14 , C07D213/85 , C07D401/12 , C07D409/06 , C07D413/12 , C07D417/12 , C07D213/64 , C07D213/69
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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公开(公告)号：US10077265B2
公开(公告)日：2018-09-18
申请号：US15513853
申请日：2015-09-22
发明人： Susanne Röhrig , Alexander Hillisch , Julia Straβburger , Stefan Heitmeier , Martina Victoria Schmidt , Karl-Heinz Schlemmer , Adrian Tersteegen , Anja Buchmüller , Christoph Gerdes , Martina Schäfer , Henrik Teller , Eloisa Jiménez Núnez , Hartmut Schirok , Jürgen Klar , Mario Lobell
IPC分类号： C07D471/04 , A61K31/435 , A61K31/437 , A61P7/02
CPC分类号： C07D471/04
摘要： The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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公开(公告)号：US09918969B2
公开(公告)日：2018-03-20
申请号：US15332893
申请日：2016-10-24
发明人： Susanne Röhrig , Alexander Hillisch , Julia Straβburger , Stefan Heitmeier , Martina Victoria Schmidt , Karl-Heinz Schlemmer , Anja Buchmüller , Christoph Gerdes , Henrik Teller , Martina Schäfer , Adrian Tersteegen
IPC分类号： A61K31/438 , A61K31/437 , C07D215/227 , C07D221/04 , C07D401/12 , C07D413/12 , C07D471/04
CPC分类号： A61K31/438 , A61K31/437 , C07D215/227 , C07D221/04 , C07D401/12 , C07D413/12 , C07D471/04
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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7.发明授权公开(公告)号：US09822102B2
公开(公告)日：2017-11-21
申请号：US15256608
申请日：2016-09-04
发明人： Susanne Röhrig , Alexander Hillisch , Julia Strassburger , Stefan Heitmeier , Martina Victoria Schmidt , Karl-Heinz Schlemmer , Adrian Tersteegen , Anja Buchmüller , Christoph Gerdes , Martina Schäfer , Tom Kinzel , Henrik Teller , Hartmut Schirok , Jürgen Klar , Eloisa Jimenez Nunez
IPC分类号： C07D413/06 , A61K31/4418 , A61K31/4412 , C07D405/06 , C07D413/14 , C07D213/85 , C07D401/12 , C07D409/06 , C07D413/12 , C07D417/12 , C07D213/64 , C07D213/69 , C07D213/84
CPC分类号： C07D405/06 , C07B2200/05 , C07D213/64 , C07D213/69 , C07D213/84 , C07D213/85 , C07D401/12 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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公开(公告)号：US10167280B2
公开(公告)日：2019-01-01
申请号：US15513977
申请日：2015-09-22
发明人： Susanne Röhrig , Eloisa Jimenez Nunez , Karl-Heinz Schlemmer , Adrian Tersteegen , Henrik Teller , Alexander Hillisch , Stefan Heitmeier , Martina Victoria Schmidt , Jens Ackerstaff , Jan Stampfuß
IPC分类号： C07D213/79 , C07D213/81 , A61K31/44 , C07D413/14 , C07D401/12 , C07D405/12 , C07D413/12 , C07D401/14 , C07D405/14
摘要： The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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公开(公告)号：US09765070B2
公开(公告)日：2017-09-19
申请号：US15032212
申请日：2014-10-28
发明人： Susanne Röhrig , Alexander Hillisch , Julia Strassburger , Stefan Heitmeier , Martina Victoria Schmidt , Karl-Heinz Schlemmer , Adrian Tersteegen , Anja Buchmüller , Christoph Gerdes , Martina Schäfer , Henrik Teller , Eloisa Jimenez Nunez , Hartmut Schirok , Jürgen Klar
IPC分类号： C07D471/02 , A61K31/44 , C07D471/04 , A61K31/437 , C07D487/04
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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公开(公告)号：US09493472B2
公开(公告)日：2016-11-15
申请号：US14895793
申请日：2014-05-30
发明人： Swen Allerheiligen , Anja Buchmüller , Karen Engel , Christoph Gerdes , Kersten Matthias Gericke , Michael Gerisch , Stefan Heitmeier , Alexander Hillisch , Tom Kinzel , Philip Lienau , Bernd Riedl , Susanne Röhrig , Martina Victoria Schmidt , Julia Strassburger , Adrian Tersteegen
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/495 , A61K31/5386 , A61K31/5377 , A61K31/423 , A61K31/454 , C07D413/06 , C07D263/58 , C07D417/06
CPC分类号： C07D487/04 , A61K31/423 , A61K31/454 , A61K31/495 , A61K31/4985 , A61K31/5377 , A61K31/5386 , C07D263/58 , C07D413/06 , C07D417/06
摘要： The invention relates to substituted benzoxazoles and to processes for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders, preferably of thrombotic or thromboembolic disorders.
摘要翻译： 本发明涉及取代的苯并恶唑及其制备方法及其制备药物用途，用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病。
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