公开(公告)号：US20070299281A1

公开(公告)日：2007-12-27

申请号：US11753096

申请日：2007-05-24

申请人： Bijan Harichian ,  Hang Chen ,  Jose Rosa

发明人： Bijan Harichian ,  Hang Chen ,  Jose Rosa

IPC分类号： C07C205/00

CPC分类号： C07C231/12 ,  C07C233/47 ,  C07C233/49

摘要： The invention relates to an improved process for oxidizing a primary amidoalcohol to the corresponding amidocarboxylic acid in high yield.

摘要翻译： 本发明涉及以高产率将伯酰胺醇氧化成相应的酰胺基羧酸的改进方法。

公开(公告)号：US20070183995A1

公开(公告)日：2007-08-09

申请号：US11350658

申请日：2006-02-09

申请人： John Nip ,  Carol Bosko ,  Jose Rosa ,  Bijan Harichian ,  Isabel Santana

发明人： John Nip ,  Carol Bosko ,  Jose Rosa ,  Bijan Harichian ,  Isabel Santana

IPC分类号： A61K8/49 ,  C07H19/16

CPC分类号： A61Q19/02 ,  A61K8/606 ,  C07H19/16 ,  C07H19/167

摘要： Compounds useful as agonists of A2A adenosine receptors are described. Also described is a cosmetically acceptable composition having an agonists of A2A adenosine receptors where the composition is suitable to apply to human skin to reduce the effects of melanin, resulting in skin whitening.

摘要翻译： 描述了可用作Aβ2A腺苷受体的激动剂的化合物。 还描述了具有Aβ2 N腺苷受体激动剂的美容上可接受的组合物，其中该组合物适用于人皮肤以减少黑色素的作用，导致皮肤美白。

公开(公告)号：US20060210497A1

公开(公告)日：2006-09-21

申请号：US11083626

申请日：2005-03-18

申请人： Bijan Harichian ,  Jose Rosa ,  John Bajor

发明人： Bijan Harichian ,  Jose Rosa ,  John Bajor

IPC分类号： C07C39/12 ,  A61K8/34

CPC分类号： A61Q19/02 ,  A61K8/347 ,  A61K8/37 ,  A61Q19/008 ,  C07C39/17 ,  C07C2601/08 ,  C07C2601/14

摘要： New 4-substituted resorcinol derivatives of general formula I and/or B and process for synthesizing same, cosmetic compositions and methods of using same, particularly for skin lightening and/or reducing the appearance of oily or greasy skin: Wherein X1 and/or X2 represents hydrogen (H), linear or branched, saturated or unsaturated C1-C12 alkyl, alkenyl, or acyl groups. Preferably, X1 and/or X2 represents hydrogen (H); linear or branched, saturated or unsaturated C1-C12 alkyl or acyl groups; R1 and/or R2 represents hydrogen (H), linear or branched, cyclic or acyclic, saturated or unsaturated C1-C12 alkyl, alkenyl, cycloalkyl, or cycloalkenyl group; n represents 0, 1. When n=0, the ring is a cyclopentyl with or without one heteroatom from O, N or S and/or with or without one double bond. When n=1, the ring is a cyclohexyl with or without one heteroatom from O, N or S and/or with or without one double bond; and m represents an integer between 1 and 6.

摘要翻译： 通式I和/或B的新的4-取代间苯二酚衍生物及其合成方法，化妆品组合物及其使用方法，特别是用于减轻油性或油性皮肤外观和/或降低油性或油性皮肤的外观：其中X 1 和/或X 2表示氢（H），直链或支链饱和或不饱和的C 1 -C 12烷基， 烯基或酰基。 优选地，X 1和/或X 2代表氢（H）; 直链或支链的饱和或不饱和的C 1 -C 12烷基或酰基; R 1和/或R 2表示氢（H），直链或支链，环状或非环状，饱和或不饱和的C 1 -C 3烷基， 烷基，烯基，环烷基或环烯基; 当n = 0时，环是具有或不具有来自O，N或S的一个杂原子的环戊基和/或具有或不具有一个双键的环戊基。 当n = 1时，环是具有或不具有来自O，N或S的一个杂原子和/或具有或不具有一个双键的环己基; m表示1〜6的整数。

公开(公告)号：US20080039636A1

公开(公告)日：2008-02-14

申请号：US11875994

申请日：2007-10-22

申请人： Bijan Harichian ,  Jose Rosa ,  Michael Barratt ,  Carol Bosko ,  John Bajor

发明人： Bijan Harichian ,  Jose Rosa ,  Michael Barratt ,  Carol Bosko ,  John Bajor

IPC分类号： C07D311/02 ,  C07C59/11 ,  C07C67/00

CPC分类号： A61K8/365 ,  A61K8/37 ,  A61K2800/782 ,  A61Q19/02 ,  C07C59/52 ,  C07C69/732

摘要： Disclosed are coumarin derived compounds of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle: Where each or both R1 and/or R2 represents hydrogen (H); linear or branched, saturated or unsaturated C1-C12 alkyl, alkenyl, acyl, or heteroalkyl (preferably, alkoxy) groups; and R3 represents linear or branched, cyclic or acyclic, saturated or unsaturated C1-C12 alkyl, alkenyl, cycloalkyl, cycloalkenyl, or heteroalkyl group; and R4 represents a hydrogen atom (H); straight or branched, cyclic or acyclic, saturated or unsaturated, containing or not containing a heteroatom C1-C22 alkyl, alkenyl, cycloalkyl, cycloalkenyl, heteroalkyl, aryl, or heteroaryl group. In a most preferred embodiment, each R1, R2 and R4 represent H, while R3 represents a methyl group, referred to herein as a 4-methyl 7-hydroxy-coumarin derivative, or coumarin derived resorcinol derivative, which may be prepared by catalytic (nickel or paladium catalyst) hydrogenation of 4-methyl 7-hydroxy-coumarin followed by hydrolysis. The inventive compounds, compositions and methods have effective skin lightening properties, may be less irritating to the skin, and are cost-effective and relatively simple to manufacture. Also disclosed are processes for making the inventive compounds of general formula I from 4-substituted-7-hydroxy coumarin derivatives.

摘要翻译： 披露式I的香豆素衍生化合物作为单独的皮肤增白剂或与其它皮肤有益剂组合以及化妆品载体：其中R 1和/或R 2中的每一个或两个， / SUB表示氢（H）; 链烯基，酰基或杂烷基（优选烷氧基）基团;直链或支链的饱和或不饱和的C 1 -C 12 - R 3表示直链或支链，环状或非环状，饱和或不饱和的C 1 -C 12烷基，烯基，环烷基，环烯基或 杂烷基 和R 4代表氢原子（H）; 直链或支链，环状或非环状，饱和或不饱和的，含或不含杂原子的C 1 -C 22烷基，烯基，环烷基，环烯基，杂烷基，芳基或 杂芳基。 在最优选的实施方案中，每个R 1，R 2和R 4均代表H，而R 3代表 甲基，本文称为4-甲基7-羟基香豆素衍生物或香豆素衍生的间苯二酚衍生物，其可以通过4-甲基7-羟基香豆素的催化（镍或咔唑催化剂）氢化，随后水解制备 。 本发明的化合物，组合物和方法具有有效的皮肤发光特性，可能对皮肤刺激性较小，并且成本有效且制造相对简单。 还公开了由4-取代-7-羟基香豆素衍生物制备本发明的通式I化合物的方法。

公开(公告)号：US07300646B2

公开(公告)日：2007-11-27

申请号：US10789293

申请日：2004-02-27

申请人： Bijan Harichian ,  Jose Rosa ,  Michael James Barratt ,  Carol Annette Bosko ,  John Steven Bajor

发明人： Bijan Harichian ,  Jose Rosa ,  Michael James Barratt ,  Carol Annette Bosko ,  John Steven Bajor

IPC分类号： A61Q19/02 ,  A61Q19/04 ,  A61K8/02 ,  A61K31/235

CPC分类号： A61K8/365 ,  A61K8/37 ,  A61K2800/782 ,  A61Q19/02 ,  C07C59/52 ,  C07C69/732

摘要： Disclosed are coumarin derived compounds of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle: Where each or both R1 and/or R2 represents hydrogen (H); linear or branched, saturated or unsaturated C1-C12 alkyl, alkenyl, acyl, or heteroalkyl (preferably, alkoxy) groups; and R3 represents linear or branched, cyclic or acyclic, saturated or unsaturated C1-C12 alkyl, alkenyl, cycloalkyl, cycloalkenyl, or heteroalkyl group; and R4 represents a hydrogen atom (H); straight or branched, cyclic or acyclic, saturated or unsaturated, containing or not containing a heteroatom C1-C22 alkyl, alkenyl, cycloalkyl, cycloalkenyl, heteroalkyl, aryl, or heteroaryl group. In a most preferred embodiment, each R1, R2 and R4 represent H, while R3 represents a methyl group, referred to herein as a 4-methyl 7-hydroxy-coumarin derivative, or coumarin derived resorcinol derivative, which may be prepared by catalytic (nickel or paladium catalyst) hydrogenation of 4-methyl 7-hydroxy-coumarin followed by hydrolysis. The inventive compounds, compositions and methods have effective skin lightening properties, may be less irritating to the skin, and are cost-effective and relatively simple to manufacture. Also disclosed are processes for making the inventive compounds of general formula I from 4-substituted-7-hydroxy coumarin derivatives.

摘要翻译： 披露式I的香豆素衍生化合物作为单独的皮肤增白剂或与其它皮肤有益剂组合以及化妆品载体：其中R 1和/或R 2中的每一个或两个， / SUB表示氢（H）; 链烯基，酰基或杂烷基（优选烷氧基）基团;直链或支链的饱和或不饱和的C 1 -C 12 - R 3表示直链或支链，环状或非环状，饱和或不饱和的C 1 -C 12烷基，烯基，环烷基，环烯基或 杂烷基 和R 4代表氢原子（H）; 直链或支链，环状或非环状，饱和或不饱和的，含或不含杂原子的C 1 -C 22烷基，烯基，环烷基，环烯基，杂烷基，芳基或 杂芳基。 在最优选的实施方案中，每个R 1，R 2和R 4均代表H，而R 3代表 甲基，本文称为4-甲基7-羟基香豆素衍生物或香豆素衍生的间苯二酚衍生物，其可以通过4-甲基7-羟基香豆素的催化（镍或咔唑催化剂）氢化，随后水解制备 。 本发明的化合物，组合物和方法具有有效的皮肤发光特性，可能对皮肤刺激性较小，并且成本有效且制造相对简单。 还公开了由4-取代-7-羟基香豆素衍生物制备本发明的通式I化合物的方法。

公开(公告)号：US20060210498A1

公开(公告)日：2006-09-21

申请号：US11084601

申请日：2005-03-18

申请人： Bijan Harichian ,  Jose Rosa

发明人： Bijan Harichian ,  Jose Rosa

IPC分类号： A61K8/34 ,  C07C39/12

CPC分类号： C07C69/017 ,  C07C39/17 ,  C07C2601/14

摘要： New 4-substituted resorcinol derivatives of general formula I and/or B and process for synthesizing same, cosmetic compositions and methods of using same, particularly for skin lightening: Wherein X1 and/or X2 represents hydrogen (H), linear or branched, saturated or unsaturated C1-C12 alkyl, alkenyl, or acyl groups. Preferably, X1 and/or X2 represents hydrogen (H); linear or branched, saturated or unsaturated C1-C12 alkyl or acyl groups; R1 represents hydrogen (H), linear or branched, cyclic or acyclic, saturated or unsaturated C1-C12 alkyl, alkenyl, cycloalkyl, or cycloalkenyl group. Preferably, R1 represents hydrogen (H) or a C1 alkyl group (i.e, methyl group). More preferably, R1 represents hydrogen; n represents 0, 1. When n=0, the ring is a cyclopentyl with or without one heteroatom from O, N or S and/or with or without one double bond. When n=1, the ring is a cyclohexyl with or without one heteroatom from O, N or S and/or with or without one double bond; and m represents an integer between 1 and 6.

摘要翻译： 新的通式I和/或B的4-取代间苯二酚衍生物及其合成方法，化妆品组合物及其使用方法，特别是皮肤增白剂：其中X 1和/或X 1， 2 H表示氢（H），直链或支链的饱和或不饱和的C 1 -C 12烷基，烯基或酰基。 优选地，X 1和/或X 2代表氢（H）; 直链或支链的饱和或不饱和的C 1 -C 12烷基或酰基; R 1表示氢（H），直链或支链，环状或非环状的饱和或不饱和的C 1 -C 12烷基，烯基，环烷基 ，或环烯基。 优选地，R 1表示氢（H）或C 1烷基（即甲基）。 更优选地，R 1表示氢; 当n = 0时，环是具有或不具有来自O，N或S的一个杂原子的环戊基和/或具有或不具有一个双键的环戊基。 当n = 1时，环是具有或不具有来自O，N或S的一个杂原子和/或具有或不具有一个双键的环己基; m表示1〜6的整数。

公开(公告)号：US20060088495A1

公开(公告)日：2006-04-27

申请号：US10972483

申请日：2004-10-25

申请人： Bijan Harichian ,  Richard Mc Manus ,  Jose Rosa

发明人： Bijan Harichian ,  Richard Mc Manus ,  Jose Rosa

IPC分类号： A61K8/41

CPC分类号： A61Q19/08 ,  A61K8/416 ,  A61Q1/02 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q15/00 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/10

摘要： A personal care product is provided which includes a composition containing dihydroxypropyltri(C1-C3 alkyl) ammonium salt in a carrier. The composition is packaged for delivery to a consumer and includes instructions printed on or associated with the packaging indicating topical use of the composition on skin, hair or the oral mucosae. Particularly useful is dihydroxypropyltrimonium chloride which operates as a humectant to moisturize both at high and low relative humidity environments.

摘要翻译： 提供了一种个人护理产品，其包括在载体中含有二羟丙基（C 1 -C 3 -C 3烷基）铵盐的组合物。 将组合物包装以递送至消费者，并包括印刷在包装上或与包装有关的说明，指示组合物在皮肤，毛发或口腔粘膜上的局部使用。 特别有用的是二羟丙基三甲基氯化铵，其作为湿润剂在高和低相对湿度环境下均湿润。

公开(公告)号：US20060047168A1

公开(公告)日：2006-03-02

申请号：US10926222

申请日：2004-08-25

申请人： Bijan Harichian ,  Jose Rosa ,  Victor De Florio

发明人： Bijan Harichian ,  Jose Rosa ,  Victor De Florio

IPC分类号： C07C62/08

CPC分类号： C07C51/367 ,  C07C59/70

摘要： Process for carboxy-alkylation, particularly carboxymethylation, of branched alcohols includes the reaction of isoalcohols with potassium-t-butoxide or sodium-t-butoxide and with salt of halogenated alkanoic acid in the presence of the isoalcohol (starting alcohol) as the solvent. Produced are isoalcohol carboxy-alkylates (preferably, carboxymethylates) in excellent yields and purity.

摘要翻译： 支链醇的羧基烷基化，特别是羧甲基化的方法包括在异构醇（起始醇）作为溶剂的存在下，异构醇与叔丁醇钾或叔丁醇钠和卤代链烷酸盐的反应。 产生的产物和纯度优异的是异烷基羧基烷基化物（优选羧甲基化物）。

公开(公告)号：US20050191250A1

公开(公告)日：2005-09-01

申请号：US10789293

申请日：2004-02-27

申请人： Bijan Harichian ,  Jose Rosa ,  Michael Barratt ,  Carol Bosko ,  John Bajor

发明人： Bijan Harichian ,  Jose Rosa ,  Michael Barratt ,  Carol Bosko ,  John Bajor

IPC分类号： A61K8/365 ,  A61K8/37 ,  A61Q19/02 ,  C07C59/52 ,  C07C69/732 ,  A61K7/42 ,  A61K7/135

CPC分类号： A61K8/365 ,  A61K8/37 ,  A61K2800/782 ,  A61Q19/02 ,  C07C59/52 ,  C07C69/732

摘要： Disclosed are coumarin derived compounds of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle: Where each or both R1 and/or R2 represents hydrogen (H); linear or branched, saturated or unsaturated C1-C12 alkyl, alkenyl, acyl, or heteroalkyl (preferably, alkoxy) groups; and R3 represents linear or branched, cyclic or acyclic, saturated or unsaturated C1-C12 alkyl, alkenyl, cycloalkyl, cycloalkenyl, or heteroalkyl group; and R4 represents a hydrogen atom (H); straight or branched, cyclic or acyclic, saturated or unsaturated, containing or not containing a heteroatom C1-C22 alkyl, alkenyl, cycloalkyl, cycloalkenyl, heteroalkyl, aryl, or heteroaryl group. In a most preferred embodiment, each R1, R2 and R4 represent H, while R3 represents a methyl group, referred to herein as a 4-methyl 7-hydroxy-coumarin derivative, or coumarin derived resorcinol derivative, which may be prepared by catalytic (nickel or paladium catalyst) hydrogenation of 4-methyl 7-hydroxy-coumarin followed by hydrolysis. The inventive compounds, compositions and methods have effective skin lightening properties, may be less irritating to the skin, and are cost-effective and relatively simple to manufacture. Also disclosed are processes for making the inventive compounds of general formula I from 4-substituted-7-hydroxy coumarin derivatives.

摘要翻译： 披露式I的香豆素衍生化合物作为单独的皮肤增白剂或与其它皮肤有益剂组合以及化妆品载体：其中R 1和/或R 2中的每一个或两个， / SUB表示氢（H）; 链烯基，酰基或杂烷基（优选烷氧基）基团;直链或支链的饱和或不饱和的C 1 -C 12 - R 3表示直链或支链，环状或非环状，饱和或不饱和的C 1 -C 12烷基，烯基，环烷基，环烯基或 杂烷基 和R 4代表氢原子（H）; 直链或支链，环状或非环状，饱和或不饱和的，含或不含杂原子的C 1 -C 22烷基，烯基，环烷基，环烯基，杂烷基，芳基或 杂芳基。 在最优选的实施方案中，每个R 1，R 2和R 4均代表H，而R 3代表 甲基，本文称为4-甲基7-羟基香豆素衍生物或香豆素衍生的间苯二酚衍生物，其可以通过4-甲基7-羟基香豆素的催化（镍或咔唑催化剂）氢化，随后水解制备 。 本发明的化合物，组合物和方法具有有效的皮肤发光特性，可能对皮肤刺激性较小，并且成本有效且制造相对简单。 还公开了由4-取代-7-羟基香豆素衍生物制备本发明的通式I化合物的方法。