公开(公告)号：US20080039636A1

公开(公告)日：2008-02-14

申请号：US11875994

申请日：2007-10-22

申请人： Bijan Harichian ,  Jose Rosa ,  Michael Barratt ,  Carol Bosko ,  John Bajor

发明人： Bijan Harichian ,  Jose Rosa ,  Michael Barratt ,  Carol Bosko ,  John Bajor

IPC分类号： C07D311/02 ,  C07C59/11 ,  C07C67/00

CPC分类号： A61K8/365 ,  A61K8/37 ,  A61K2800/782 ,  A61Q19/02 ,  C07C59/52 ,  C07C69/732

摘要： Disclosed are coumarin derived compounds of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle: Where each or both R1 and/or R2 represents hydrogen (H); linear or branched, saturated or unsaturated C1-C12 alkyl, alkenyl, acyl, or heteroalkyl (preferably, alkoxy) groups; and R3 represents linear or branched, cyclic or acyclic, saturated or unsaturated C1-C12 alkyl, alkenyl, cycloalkyl, cycloalkenyl, or heteroalkyl group; and R4 represents a hydrogen atom (H); straight or branched, cyclic or acyclic, saturated or unsaturated, containing or not containing a heteroatom C1-C22 alkyl, alkenyl, cycloalkyl, cycloalkenyl, heteroalkyl, aryl, or heteroaryl group. In a most preferred embodiment, each R1, R2 and R4 represent H, while R3 represents a methyl group, referred to herein as a 4-methyl 7-hydroxy-coumarin derivative, or coumarin derived resorcinol derivative, which may be prepared by catalytic (nickel or paladium catalyst) hydrogenation of 4-methyl 7-hydroxy-coumarin followed by hydrolysis. The inventive compounds, compositions and methods have effective skin lightening properties, may be less irritating to the skin, and are cost-effective and relatively simple to manufacture. Also disclosed are processes for making the inventive compounds of general formula I from 4-substituted-7-hydroxy coumarin derivatives.

摘要翻译： 披露式I的香豆素衍生化合物作为单独的皮肤增白剂或与其它皮肤有益剂组合以及化妆品载体：其中R 1和/或R 2中的每一个或两个， / SUB表示氢（H）; 链烯基，酰基或杂烷基（优选烷氧基）基团;直链或支链的饱和或不饱和的C 1 -C 12 - R 3表示直链或支链，环状或非环状，饱和或不饱和的C 1 -C 12烷基，烯基，环烷基，环烯基或 杂烷基 和R 4代表氢原子（H）; 直链或支链，环状或非环状，饱和或不饱和的，含或不含杂原子的C 1 -C 22烷基，烯基，环烷基，环烯基，杂烷基，芳基或 杂芳基。 在最优选的实施方案中，每个R 1，R 2和R 4均代表H，而R 3代表 甲基，本文称为4-甲基7-羟基香豆素衍生物或香豆素衍生的间苯二酚衍生物，其可以通过4-甲基7-羟基香豆素的催化（镍或咔唑催化剂）氢化，随后水解制备 。 本发明的化合物，组合物和方法具有有效的皮肤发光特性，可能对皮肤刺激性较小，并且成本有效且制造相对简单。 还公开了由4-取代-7-羟基香豆素衍生物制备本发明的通式I化合物的方法。

公开(公告)号：US20050191250A1

公开(公告)日：2005-09-01

申请号：US10789293

申请日：2004-02-27

申请人： Bijan Harichian ,  Jose Rosa ,  Michael Barratt ,  Carol Bosko ,  John Bajor

发明人： Bijan Harichian ,  Jose Rosa ,  Michael Barratt ,  Carol Bosko ,  John Bajor

IPC分类号： A61K8/365 ,  A61K8/37 ,  A61Q19/02 ,  C07C59/52 ,  C07C69/732 ,  A61K7/42 ,  A61K7/135

CPC分类号： A61K8/365 ,  A61K8/37 ,  A61K2800/782 ,  A61Q19/02 ,  C07C59/52 ,  C07C69/732

摘要： Disclosed are coumarin derived compounds of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle: Where each or both R1 and/or R2 represents hydrogen (H); linear or branched, saturated or unsaturated C1-C12 alkyl, alkenyl, acyl, or heteroalkyl (preferably, alkoxy) groups; and R3 represents linear or branched, cyclic or acyclic, saturated or unsaturated C1-C12 alkyl, alkenyl, cycloalkyl, cycloalkenyl, or heteroalkyl group; and R4 represents a hydrogen atom (H); straight or branched, cyclic or acyclic, saturated or unsaturated, containing or not containing a heteroatom C1-C22 alkyl, alkenyl, cycloalkyl, cycloalkenyl, heteroalkyl, aryl, or heteroaryl group. In a most preferred embodiment, each R1, R2 and R4 represent H, while R3 represents a methyl group, referred to herein as a 4-methyl 7-hydroxy-coumarin derivative, or coumarin derived resorcinol derivative, which may be prepared by catalytic (nickel or paladium catalyst) hydrogenation of 4-methyl 7-hydroxy-coumarin followed by hydrolysis. The inventive compounds, compositions and methods have effective skin lightening properties, may be less irritating to the skin, and are cost-effective and relatively simple to manufacture. Also disclosed are processes for making the inventive compounds of general formula I from 4-substituted-7-hydroxy coumarin derivatives.

摘要翻译： 披露式I的香豆素衍生化合物作为单独的皮肤增白剂或与其它皮肤有益剂组合以及化妆品载体：其中R 1和/或R 2中的每一个或两个， / SUB表示氢（H）; 链烯基，酰基或杂烷基（优选烷氧基）基团;直链或支链的饱和或不饱和的C 1 -C 12 - R 3表示直链或支链，环状或非环状，饱和或不饱和的C 1 -C 12烷基，烯基，环烷基，环烯基或 杂烷基 和R 4代表氢原子（H）; 直链或支链，环状或非环状，饱和或不饱和的，含或不含杂原子的C 1 -C 22烷基，烯基，环烷基，环烯基，杂烷基，芳基或 杂芳基。 在最优选的实施方案中，每个R 1，R 2和R 4均代表H，而R 3代表 甲基，本文称为4-甲基7-羟基香豆素衍生物或香豆素衍生的间苯二酚衍生物，其可以通过4-甲基7-羟基香豆素的催化（镍或咔唑催化剂）氢化，随后水解制备 。 本发明的化合物，组合物和方法具有有效的皮肤发光特性，可能对皮肤刺激性较小，并且成本有效且制造相对简单。 还公开了由4-取代-7-羟基香豆素衍生物制备本发明的通式I化合物的方法。

公开(公告)号：US20050255056A1

公开(公告)日：2005-11-17

申请号：US10843489

申请日：2004-05-11

申请人： John Bajor ,  Michael Barratt ,  Carol Bosko

发明人： John Bajor ,  Michael Barratt ,  Carol Bosko

IPC分类号： A61K8/97 ,  A61K8/99 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61K7/42 ,  A61K7/135

CPC分类号： A61K8/99 ,  A61Q19/02

摘要： Disclosed are extracts of Nigrospora sphaerica as cosmetic skin benefit agents, preferably as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle. The inventive extracts, compositions and methods have effective skin lightening properties, may be easier to deliver to the skin, and are commercially available or cost-effective and available in nature.

摘要翻译： 公开了作为化妆品皮肤有益剂的黑曲霉的提取物，优选单独使用作为皮肤增白剂或与其它皮肤有益剂组合，并与化妆品载体一起使用。 本发明的提取物，组合物和方法具有有效的皮肤发光特性，可以更容易地递送到皮肤，并且是商业上可获得的或成本有效的并且在自然界中可获得。

公开(公告)号：US6074998A

公开(公告)日：2000-06-13

申请号：US12990

申请日：1998-01-26

申请人： Mengtao He ,  Michael Barratt ,  James Dalton ,  Michael Fair ,  Michael Petko ,  John Sheehan ,  Abid Khan-Lodhi

发明人： Mengtao He ,  Michael Barratt ,  James Dalton ,  Michael Fair ,  Michael Petko ,  John Sheehan ,  Abid Khan-Lodhi

IPC分类号： A61K8/37 ,  A61K8/86 ,  A61Q19/10 ,  C11D3/18 ,  C11D3/20 ,  C11D3/37 ,  C11D17/00 ,  A61K7/50

CPC分类号： A61K8/375 ,  A61K8/86 ,  A61Q19/10 ,  C11D17/006 ,  C11D3/18 ,  C11D3/2003 ,  C11D3/2065 ,  C11D3/2093 ,  C11D3/3707 ,  C11D3/373 ,  C11D3/3738 ,  C11D3/2024 ,  C11D3/2044 ,  C11D3/2051

摘要： The present invention relates to solid detergent compositions generally comprising anionic/amphoteric/nonionic surfactant systems. Addition of specific polyol esters wherein the melting temperature and HLB are specifically defined has been found to remarkably enhance the oil/humectant structuring and releasing capabilities of a skin cleansing bar. In a second embodiment, the invention relates to a method for enhancing the bar's capability of including high levels of oil and/or humectant by carefully balancing the polyol ester's weight ratio to the oil and/or humectant. In the third embodiment, the invention relates to a method of enhancing the bar's capability of incorporating high levels of oil and/or humectant and delivering the oil and/or humectant for skin benefit by carefully balancing the polyol ester's weight ratio to the other costructurants such as PEG 8000 and fatty acid. In the third embodiment, skin mildness and especially skin moisturization are significantly enhanced by the detergent bar compositions comprising the combination of the specific polyol ester with oil and/or humectant.

摘要翻译： 本发明涉及通常包含阴离子/两性/非离子表面活性剂体系的固体洗涤剂组合物。 已经发现加入特定的多元醇酯，其中熔融温度和HLB被特别限定，显着增强了皮肤清洁条的油/保湿剂结构和释放能力。 在第二个实施方案中，本发明涉及通过将多元醇酯的重量比与油和/或湿润剂仔细平衡来提高棒的包含高含量油和/或湿润剂的能力的方法。 在第三个实施方案中，本发明涉及通过仔细地将多元醇酯的重量比与其它共同结构化剂进行平衡来提高棒的掺入高水平的油和/或湿润剂并递送油和/或保湿剂以获得皮肤益处的方法， 如PEG 8000和脂肪酸。 在第三个实施方案中，通过包含特定多元醇酯与油和/或湿润剂的组合的洗涤剂棒组合物，皮肤温和性，特别是皮肤保湿显着增强。