公开(公告)号：US20230125059A1

公开(公告)日：2023-04-20

申请号：US18052544

申请日：2022-11-03

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Evan THRUSH ,  Stephen L. SWIHART ,  Eli A. HEFNER ,  Michael GRIFFIN ,  Li LU

IPC: G01N21/64 ,  G01N21/71

Abstract: A fluorescence detection system, including apparatus and methods, suitable for qPCR and other fluorescence-based analyses. The system may comprise various components, including a stage, an illumination module, a detection module, and an optical relay structure. The stage may be configured to support a sample holder. The illumination module may include one or more discrete light sources configured to produce excitation light. The detection module may be configured to detect fluorescence emission light produced, in response to the excitation light, by a fluorescent sample positioned in the sample holder. The optical relay structure may include a beamsplitter assembly configured to direct the excitation light from the illumination module along an illumination path to the sample holder and to direct the fluorescence emission light from the sample holder along a response path to the imaging module. The system may enhance the quality of excitation light hitting samples in the sample holder.

公开(公告)号：US20210199568A1

公开(公告)日：2021-07-01

申请号：US17199312

申请日：2021-03-11

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Evan THRUSH ,  Steven SWIHART ,  William STRONG ,  Trey MARLOWE ,  Li LU

IPC: G01N21/31 ,  G01N21/3577 ,  G01N21/3563

Abstract: Systems for protein quantitation using a Fabry-Perot interferometer. In one arrangement, a quantitation device includes an infrared source, a sample holder, and a Fabry-Perot interferometer positioned to receive infrared radiation from the source passing through a sample on the sample holder. A band pass optical filter sets the working range of the interferometer, and radiation exiting the interferometer falls on a detector that produces a signal indicating the intensity of the received radiation. A controller causes the interferometer to be tuned to a number of different resonance wavelengths and receives the intensity signals, for determination of an absorbance spectrum.

公开(公告)号：US20230026156A1

公开(公告)日：2023-01-26

申请号：US17877680

申请日：2022-07-29

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Evan THRUSH ,  Steven SWIHART ,  William STRONG ,  Trey MARLOWE ,  Li LU

IPC: G01N21/31 ,  G01N21/3577 ,  G01N21/3563

Abstract: Systems for protein quantitation using a Fabry-Perot interferometer. In one arrangement, a quantitation device includes an infrared source, a sample holder, and a Fabry-Perot interferometer positioned to receive infrared radiation from the source passing through a sample on the sample holder. A band pass optical filter sets the working range of the interferometer, and radiation exiting the interferometer falls on a detector that produces a signal indicating the intensity of the received radiation. A controller causes the interferometer to be tuned to a number of different resonance wavelengths and receives the intensity signals, for determination of an absorbance spectrum.