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公开(公告)号：US20170332001A1
公开(公告)日：2017-11-16
申请号：US15667435
申请日：2017-08-02
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Steve SWIHART , Evan THRUSH , Boaz RAN
CPC classification number: H04N5/2355 , G01N21/272 , G01N21/6408 , G01N21/6456 , G01N21/76 , H04N5/2173 , H04N5/2353 , H04N5/35545 , H04N5/361 , H04N5/365
Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.
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公开(公告)号：US20190072490A1
公开(公告)日：2019-03-07
申请号：US16110333
申请日：2018-08-23
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Evan THRUSH , Steve SWIHART
Abstract: Devices and methods are disclosed for the substantially uniform epi-illumination of samples such as western blots using high power lasers. The uniformity of illumination is provided by particular configurations of optical diffusers, spatial or temporal laser modalities, or numbers of lasers. The increased excitation light produced by the high power lasers can enhance fluorescence emission signal strength and reduce required imaging exposure times.
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公开(公告)号：US20230199130A1
公开(公告)日：2023-06-22
申请号：US18082330
申请日：2022-12-15
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Stephen SWIHART , Evan THRUSH , Carl MARLOWE , Kenneth OH , Michael GRIFFIN
IPC: H04N1/10 , H04N1/028 , G06T5/50 , G06V10/141
CPC classification number: H04N1/1008 , H04N1/02865 , G06T5/50 , G06V10/141 , G06T2207/20221
Abstract: Systems and methods for contact imaging of stands with illumination are disclosed herein. A contact imaging system can include a contact imager. The contact imager can include a housing having a base and a lid. The lid can have a closed position against the base and an open position. The contact imager can include a contact area image sensor. The lid can shield the contact area image sensor from ambient light when the lid is in the closed position. The contact imager can include an illuminator that can illuminate at least a portion of a blot on the contact area image sensor when the lid is in the closed position.
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公开(公告)号：US20210199568A1
公开(公告)日：2021-07-01
申请号：US17199312
申请日：2021-03-11
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Evan THRUSH , Steven SWIHART , William STRONG , Trey MARLOWE , Li LU
IPC: G01N21/31 , G01N21/3577 , G01N21/3563
Abstract: Systems for protein quantitation using a Fabry-Perot interferometer. In one arrangement, a quantitation device includes an infrared source, a sample holder, and a Fabry-Perot interferometer positioned to receive infrared radiation from the source passing through a sample on the sample holder. A band pass optical filter sets the working range of the interferometer, and radiation exiting the interferometer falls on a detector that produces a signal indicating the intensity of the received radiation. A controller causes the interferometer to be tuned to a number of different resonance wavelengths and receives the intensity signals, for determination of an absorbance spectrum.
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公开(公告)号：US20230086701A1
公开(公告)日：2023-03-23
申请号：US17946555
申请日：2022-09-16
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Evan THRUSH , Stephen SWIHART , Kevin McDONALD
Abstract: Aspects of the present disclosure relate to systems and methods for generating a composite image. This can include a western blot imager with a real time camera. One aspect of the present disclosure relates to an imaging system. The imaging system includes a sample plane that can receive and hold a sample, a photon resolving camera, and a lens attached to the photon resolving camera, the photon resolving camera and the lens positioned to image the sample plane.
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Patent Agency Ranking
公开(公告)号：US20230026156A1
公开(公告)日：2023-01-26
申请号：US17877680
申请日：2022-07-29
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Evan THRUSH , Steven SWIHART , William STRONG , Trey MARLOWE , Li LU
IPC: G01N21/31 , G01N21/3577 , G01N21/3563
Abstract: Systems for protein quantitation using a Fabry-Perot interferometer. In one arrangement, a quantitation device includes an infrared source, a sample holder, and a Fabry-Perot interferometer positioned to receive infrared radiation from the source passing through a sample on the sample holder. A band pass optical filter sets the working range of the interferometer, and radiation exiting the interferometer falls on a detector that produces a signal indicating the intensity of the received radiation. A controller causes the interferometer to be tuned to a number of different resonance wavelengths and receives the intensity signals, for determination of an absorbance spectrum.
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公开(公告)号：US20220178874A1
公开(公告)日：2022-06-09
申请号：US17544591
申请日：2021-12-07
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Kenneth OH , Carl MARLOWE , Stephen L. SWIHART , Evan THRUSH , Michael GRIFFIN
IPC: G01N27/447 , G01N33/68 , G01N21/64
Abstract: Methods and reference compositions for quantifying protein using tagged standards. In an exemplary method, a reference composition and a protein may be electrophoresed in respective lanes of a gel. The reference composition may include quantitation standards of different size and each including a tag present at a different concentration. The quantitation standards and the protein may be transferred from the gel to a solid support to create a blot. Luminescence may be detected from the blot to obtain respective luminescence values separately representing an abundance of the tag of each quantitation standard and an abundance of the protein. A quantity of the protein may be determined using the respective luminescence values.
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公开(公告)号：US20170366768A1
公开(公告)日：2017-12-21
申请号：US15675494
申请日：2017-08-11
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Boaz RAN , Steve SWIHART , Evan THRUSH , Itay BARAK
Abstract: In one application, an imaging device includes an image sensor having an array of pixels, and a mask coupled with the image sensor. The mask is configured to darken a plurality of isolated pixels or groups of pixels interspersed within the array of pixels. The imaging device also includes a processor coupled with the image sensor and configured to receive image data from the image sensor, and determine a dark current fixed pattern noise based on the image data received from the plurality of darkened pixels or groups of pixels.
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公开(公告)号：US20240302641A1
公开(公告)日：2024-09-12
申请号：US18597463
申请日：2024-03-06
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Evan THRUSH , Stephen SWIHART
CPC classification number: G02B21/361 , G02B21/086
Abstract: The present relates to chromatic focusing via filter thickness tuning. Chromatic focusing can be achieved via an imaging system that includes a sample holding plane, a light source that illuminates the sample on the plane, and an imager that captures an image of the sample on the plane. The imager includes a sensor, a lens, and a filter wheel defining a plurality of filter apertures including a first aperture containing a first filter passing light of a first color and having a first focal point shift, and a second aperture containing a second filter passing light of a second color and having a second focal point shift. The focal point shifts cause both light of the first color passing through the first filter and through the lens and light of the second color passing through the second filter and through the lens to focus on the sensor.
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10.发明公开公开(公告)号：US20240302323A1
公开(公告)日：2024-09-12
申请号：US18594870
申请日：2024-03-04
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Kevin McDONALD , Evan THRUSH , Stephen SWIHART
IPC: G01N27/447 , H04N23/56
CPC classification number: G01N27/44721 , G01N27/44739 , H04N23/56
Abstract: Systems, methods, and devices for imaging of stain-free fluorescence on western blot membranes with excitation by epi illumination with UV LEDs are disclosed herein. A method can include collecting and preparing a sample, separating the sample via gel electrophoresis in a gel block, transferring the separated sample from the gel block to an analysis block, generating an image of the sample with an imager, and evaluating the image of the sample. The imager can include a plane to receive and hold a block containing a sample and including a first side and a second side, a camera to image a sample on the plane and positioned above the first side of the plane, and an LED light source positioned above the first side of the plane. The LED light source can illuminate the sample on the plane via epi-illumination, and emits light having a wavelength in a range from approximately 325 nm to approximately 400 nm.
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