公开(公告)号：US11753668B2

公开(公告)日：2023-09-12

申请号：US17591171

申请日：2022-02-02

Applicant: Biogen MA Inc.

Inventor： Fernie Mitchelson ,  Erik Hughes ,  Jessica Mondia ,  Robin Parish Hyde-Deruyscher

IPC: C12P21/00 ,  C12N5/00 ,  C07K16/28

CPC classification number: C12P21/005 ,  C07K16/2839 ,  C12N5/0018 ,  C07K2317/14 ,  C07K2317/40 ,  C07K2317/41 ,  C12N2500/10 ,  C12N2500/20 ,  C12N2511/00 ,  C12N2513/00

Abstract: The present invention pertains to a cell culture medium comprising copper as a media supplement, which was shown to control recombinant protein glycosylation and methods of sing thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.

公开(公告)号：US11268119B2

公开(公告)日：2022-03-08

申请号：US15519731

申请日：2015-10-16

Applicant: Biogen MA Inc.

Inventor： Fernie Mitchelson ,  Erik Heller Hughes ,  Jessica Mondia ,  Robin Parish Hyde-Deruyscher

IPC: C12P21/00 ,  C12N5/00 ,  C07K16/28

Abstract: The present invention pertains to a cell culture medium comprising copper as a media supplement, which was shown to control recombinant protein glycosylation and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.

公开(公告)号：US20220315973A1

公开(公告)日：2022-10-06

申请号：US17591171

申请日：2022-02-02

Applicant: Biogen MA Inc.

Inventor： Fernie Mitchelson ,  Erik Hughes ,  Jessica Mondia ,  Robin Parish Hyde-Deruyscher

IPC: C12P21/00 ,  C12N5/00 ,  C07K16/28

Abstract: The present invention pertains to a cell culture medium comprising copper as a media supplement, which was shown to control recombinant protein glycosylation and methods of sing thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.