公开(公告)号：US20230175967A1

公开(公告)日：2023-06-08

申请号：US17885167

申请日：2022-08-10

Applicant: Biogen MA Inc.

Inventor： JUSTIN MORETTO ,  Brandon Berry ,  Alex Doane

IPC: G01N21/65 ,  G01J3/44

CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2201/0446 ,  G01N2201/06113

Abstract: In one aspect, the disclosure provides a method of defining a Raman signature of a culture component, the method comprising: obtaining a Raman spectrum of a culture component in a non-interfering or minimally-interfering solution, identifying peaks in the Raman spectrum that are associated with the culture component, obtaining a Raman spectrum of a culture medium comprising the culture component, and, removing peaks of the culture component in the Raman spectrum of the culture medium that are distorted compared to the peaks identified in the Raman spectrum of the culture component in a non-interfering or minimally-interfering solution.