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    Microplate reader with lid lifter for microplates
    2.
    发明授权
    Microplate reader with lid lifter for microplates 有权
    微孔板读取器，带有微孔板盖提升器

    公开(公告)号：US09568414B2

    公开(公告)日：2017-02-14

    申请号：US14697012

    申请日：2015-04-27

    Applicant: TECAN TRADING AG

    Inventor： Friedrich Menges ,  Harald Gebetsroither ,  Gyoergy Wenczel

    IPC: G01N21/01 ,  G01N21/63 ,  G01N21/76 ,  G01N21/64 ,  G01N21/03

    CPC classification number: G01N21/0303 ,  G01N21/6428 ,  G01N21/76 ,  G01N35/028 ,  G01N35/04 ,  G01N2021/036 ,  G01N2035/00287 ,  G01N2035/0405 ,  G01N2201/022 ,  G01N2201/0446 ,  Y10S436/807

    Abstract: Microplate reader has a housing, at least one optical measuring/detection device, a microplate support, a moving unit and an integrated lid holding apparatus. The lid holding apparatus moves the microplate in one respective, at least approximately vertical direction for moving the microplate lid away from the microplate. The lid holding apparatus is arranged inside the housing as a magnetic lifter and comprises a non-array arrangement of at least one permanent magnet, or at least three electro magnets, or at least one switchable permanent magnet. Each microplate lid to be moved away from the microplate comprises magnetizable material with a physical area. A projected area of the at least one permanent magnet, electro magnet, or switchable permanent magnet is smaller than the physical area of the magnetizable material of the microplate lid.

    Abstract translation: 酶标板读取器具有壳体，至少一个光学测量/检测装置，微孔板支架，移动单元和一体式盖保持装置。 盖保持装置使微板在一个相应的至少大致垂直的方向上移动，以使微板盖远离微板。 盖保持装置作为磁性提升器布置在壳体内部，并且包括至少一个永磁体或至少三个电磁体或至少一个可切换永磁体的非阵列布置。 每个微板盖要移动离开微板包括具有物理区域的可磁化材料。 所述至少一个永磁体，电磁体或可切换永磁体的投影面积小于微板盖板的可磁化材料的物理面积。

    METHOD AND APPARATUS FOR BACTERIAL MONITORING
    4.
    发明申请
    METHOD AND APPARATUS FOR BACTERIAL MONITORING 审中-公开
    用于细菌监测的方法和装置

    公开(公告)号：US20160061822A1

    公开(公告)日：2016-03-03

    申请号：US14779977

    申请日：2014-03-25

    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. ,  TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.

    Inventor： Amir SA'AR ,  Ester SEGAL

    IPC: G01N33/53 ,  G01N21/47

    CPC classification number: G01N33/5302 ,  G01D5/266 ,  G01N21/4738 ,  G01N21/4788 ,  G01N21/85 ,  G01N2201/0446 ,  G01N2201/061

    Abstract: A system for detecting target elements such as bacteria in a host analyte, comprising a substrate with an ordered array of wells having diameters to fit the size of the targets. The substrate may be a periodic macro-PSi array structure (MPSiAS) illuminated with a broadband source. The reflected light spectrum diffracted from the substrate is optically analyzed to provide the effective optical depth of the wells. Fast Fourier Transform analysis may be used for the optical analysis. Entry of target elements into wells is detected by the change in the effective optical depths of the wells. Micro-organisms as large as bacteria and viruses having dimensions comparable with the wavelength of the illumination can thus be detected. Wells with an inner section impenetrable by the target cells enables compensation for environmental changes. The detection may be performed in real time, such that production line bacterial monitoring may be achieved.

    Abstract translation: 一种用于检测宿主分析物中诸如细菌的目标元素的系统，包括具有适合靶标大小的直径的有序排列阵列的基底。 衬底可以是用宽带源照明的周期性宏观PSi阵列结构（MPSiAS）。 从衬底衍射的反射光谱被光学分析以提供孔的有效光学深度。 快速傅里叶变换分析可用于光学分析。 通过孔的有效光学深度的变化来检测目标元素进入井中。 因此可以检测到具有与照明波长相当的尺寸的细菌和病毒的微生物。 具有目标细胞不可渗透的内部部分的井可以补偿环境变化。 检测可以实时进行，从而可以实现生产线细菌监测。

    LED densitometer for microtiter plate
    5.
    发明授权
    LED densitometer for microtiter plate 有权
    用于微量滴定板的LED光密度计

    公开(公告)号：US09243996B2

    公开(公告)日：2016-01-26

    申请号：US13383986

    申请日：2010-07-16

    Applicant: Peter Van Praet

    Inventor： Peter Van Praet

    IPC: G01N21/00 ,  G01N21/25

    CPC classification number: G01N21/00 ,  G01N21/253 ,  G01N2201/0446 ,  G01N2201/0453 ,  G01N2201/0627 ,  G01N2201/10

    Abstract: Light emitting diodes (LEDs) are mounted in an array to an upper structure overlying a lower structure with a plurality of light detectors thereon. Each LED is configured to overlie a separate detector. Each LED emits light at a frequency relevant for measuring optical density of a specimen. LEDs having different frequencies are included within the LED array. A corresponding array of detectors is also provided, mounted to the lower structure. Spacing between adjacent LEDs and between adjacent detectors match a spacing between wells in a microtiter plate. Spacing between the lower structure and the upper structure supporting the LEDs is sufficient for the microtiter plate to fit between. Circuitry sequentially fires individual LEDs and gathers optical density data through the detectors for specimens in the wells of the microtiter plate. The structures are then moved to a next adjacent well position on the microtiter plate and the process repeated.

    Abstract translation: 发光二极管（LED）以阵列的形式安装在覆盖下部结构的上部结构上，其上具有多个光检测器。 每个LED被配置为覆盖单独的检测器。 每个LED以与测量样品的光密度相关的频率发光。 具有不同频率的LED包括在LED阵列内。 还提供了相应的检测器阵列，安装到下部结构。 相邻LED之间和相邻检测器之间的间距与微量滴定板中的孔之间的间距相匹配。 支撑LED的下部结构和上部结构之间的间距足以使微量滴定板相适应。 电路依次点火各个LED，并通过微量滴定板孔中的标本的检测器收集光密度数据。 然后将结构移动到微量滴定板上的下一个相邻的孔位置，并重复该过程。

    METHOD FOR OBSERVING STEM CELLS, METHOD FOR REMOVAL OF CELL REGION IN STATE TENDING TOWARD DIFFERENTIATION, AND DEVICE FOR OBSERVING STEM CELLS
    7.
    发明申请
    METHOD FOR OBSERVING STEM CELLS, METHOD FOR REMOVAL OF CELL REGION IN STATE TENDING TOWARD DIFFERENTIATION, AND DEVICE FOR OBSERVING STEM CELLS 有权
    用于观察干细胞的方法，用于移除状态趋势分化中的细胞区域的方法，以及用于观察干细胞的装置

    公开(公告)号：US20140287452A1

    公开(公告)日：2014-09-25

    申请号：US14356487

    申请日：2012-10-23

    Applicant: HAMAMATSU PHOTONICS K.K.

    Inventor： Norikazu Sugiyama ,  Takuji Kataoka ,  Ikuo Arata

    IPC: G01N33/50

    CPC classification number: G01N21/47 ,  G01N21/49 ,  G01N21/59 ,  G01N33/4833 ,  G01N33/5005 ,  G01N2201/0446 ,  G01N2201/062 ,  G02B21/088 ,  G02B21/36

    Abstract: A method for observing stem cells by an observation device 1 comprises, placing stem cells C in a petri dish 11, mounting the petri dish 11 on a waveguide 21 via water 13, emitting illumination light L1 into the waveguide 21 and emitting the illumination light L1 to the stem cells C in the petri dish 11 via the water 13, and detecting scattered light L2, the scattered light L2 being the illumination light L1 emitted to the stem cells C that is scattered by the stem cells C and has passed through the waveguide 21. Then, in the light image detected by means of the scattered light L2, a region that is markedly darker than other regions is identified as being in the state tending toward differentiation.

    Abstract translation: 通过观察装置1观察干细胞的方法包括：将干细胞C放置在培养皿11中，通过水13将培养皿11安装在波导21上，将照明光L1发射到波导21中并发射照明光L1 通过水13向陪替氏培养皿11中的干细胞C，并且检测散射光L2，散射光L2是发射到干细胞C的干细胞C的照射光L1，其被干细胞C散射并已经通过波导 然后，在通过散射光L2检测到的光图像中，比其他区域明显更暗的区域被识别为处于朝向微分的状态。

    Blood analysis apparatus and setting method of measurement position in blood analysis apparatus
    8.
    发明授权
    Blood analysis apparatus and setting method of measurement position in blood analysis apparatus 有权
    血液分析仪器血液分析仪器及测量位置的设定方法

    公开(公告)号：US08248586B2

    公开(公告)日：2012-08-21

    申请号：US12427280

    申请日：2009-04-21

    Applicant: Mamoru Tomita

    Inventor： Mamoru Tomita

    IPC: G01N33/48 ,  G01N21/00 ,  G01B11/00 ,  G01B11/14

    CPC classification number: G01N21/07 ,  G01N21/59 ,  G01N35/00584 ,  G01N35/025 ,  G01N2035/00148 ,  G01N2201/0415 ,  G01N2201/0446 ,  G01N2201/1247

    Abstract: A blood analysis apparatus is provided. The blood analysis apparatus includes: a chip holding portion having an aperture which allows light to pass therethrough and holding a μ-TAS chip for holding a measurement liquid; a rotary body on which the chip holding portion is mounted; a light source; and a light-receiving unit. A measurement position of the rotary body at which the measurement liquid is to be measured with the light from the light source is set by: rotating the rotary body to obtain a light value of light which is emitted from the light source and received by the light-receiving unit through the aperture; and setting a rotational position of the rotary body where the light value is a threshold value or more, as the measurement position.

    Abstract translation: 提供血液分析装置。 血液分析装置包括：芯片保持部，具有允许光通过的孔，并保持用于保持测量液体的μ-TAS芯片; 旋转体，其上安装有芯片保持部; 光源; 和光接收单元。 利用来自光源的光来测量测量液体的旋转体的测量位置是通过旋转旋转体来获得从光源发射并被光接收的光的光值 - 接收单元通过孔径; 并且将光值为阈值以上的旋转体的旋转位置设定为测量位置。

    Biochemical analyzer
    9.
    发明授权
    Biochemical analyzer 有权
    生化分析仪

    公开(公告)号：US07978325B2

    公开(公告)日：2011-07-12

    申请号：US12121120

    申请日：2008-05-15

    Applicant: Sakuichiro Adachi

    Inventor： Sakuichiro Adachi

    IPC: G01J3/04 ,  G01J3/28

    CPC classification number: G01N21/253 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0262 ,  G01J3/04 ,  G01J3/36 ,  G01J3/42 ,  G01N21/13 ,  G01N21/255 ,  G01N2021/0325 ,  G01N2021/115 ,  G01N2021/3155 ,  G01N2201/0415 ,  G01N2201/0446 ,  G01N2201/0453 ,  G01N2201/0618

    Abstract: A light amount is increased and an analyzing accuracy can be kept in accordance with an enlargement of a load angle, however, a scattered light tends to be loaded in an analysis accompanying the scattered light and a dynamic range of a concentration which can be measured becomes narrow. A light is dispersed by a light dispersing portion, a load angle of the received light is changed per wavelength, the load angle is made larger in the light of a wavelength having a small light amount, and the load angle is made smaller in the light a wavelength having a large light amount and used for an analysis accompanying a scattered light. Accordingly, it is possible to gain a dynamic range of a concentration which can be measured in the analysis accompanying the scattered light, while increasing the light amount and maintaining the analyzing accuracy.

    Abstract translation: 光量增加，并且可以根据负载角的放大来保持分析精度，然而，伴随散射光的分析倾向于加载散射光，并且可测量的浓度的动态范围变为 狭窄。 通过光分散部分散射光，每波长改变接收光的负载角度，在具有小光量的波长的光中使负载角变大，并且使光的负载角变小 具有大光量的波长并用于伴随散射光的分析。 因此，在增加光量并保持分析精度的同时，可以获得在伴随散射光的分析中可以测量的浓度的动态范围。

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