专利检索 ap:("Blood Systems, Inc." OR "University of Hawaii" OR "GalPharma Co., Ltd.") AND inv:"Misuomi Harashima" 第 1 页

1.

发明申请
REVERSAL OF LATENCY OF RETROVIRUSES WITH A GALECTIN PROTEIN 审中-公开

公开(公告)号：US20180153901A1

公开(公告)日：2018-06-07

申请号：US15558178

申请日：2016-03-10

申请人： Blood Systems, Inc. , University of Hawaii , GalPharma Co., Ltd.

发明人： Satish K. Pillai , Mohamed Abdel-Mohsen , Leonard Chavez , Lishomwa Ndhlovu , Ravi Tandon , Toshiro Niki , Misuomi Harashima

IPC分类号： A61K31/551 , A61K38/17 , A61K45/06

CPC分类号： A61K31/551 , A61K38/1732 , A61K45/06 , A61P31/12 , C12N2740/16063 , A61K2300/00

摘要： The present invention relates to the seminal discovery of methods of using recombinant galectin proteins to reverse HIV latency. Specifically, the present invention relates to the use of recombinant galectin-9 (rGal-9) to reactivate latent HIV, wherein the HIV is hypermutated rendering the virus replication incompetent. Further, rGal-9 induces the expression of APOBEC3 cytidine deaminases and NFkB pathway components and decreases histone deacetylase (HDAC) expression.