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公开(公告)号：US20180153901A1
公开(公告)日：2018-06-07
申请号：US15558178
申请日：2016-03-10
发明人： Satish K. Pillai , Mohamed Abdel-Mohsen , Leonard Chavez , Lishomwa Ndhlovu , Ravi Tandon , Toshiro Niki , Misuomi Harashima
IPC分类号： A61K31/551 , A61K38/17 , A61K45/06
CPC分类号： A61K31/551 , A61K38/1732 , A61K45/06 , A61P31/12 , C12N2740/16063 , A61K2300/00
摘要： The present invention relates to the seminal discovery of methods of using recombinant galectin proteins to reverse HIV latency. Specifically, the present invention relates to the use of recombinant galectin-9 (rGal-9) to reactivate latent HIV, wherein the HIV is hypermutated rendering the virus replication incompetent. Further, rGal-9 induces the expression of APOBEC3 cytidine deaminases and NFkB pathway components and decreases histone deacetylase (HDAC) expression.
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2.发明授权公开(公告)号：US09528089B2
公开(公告)日：2016-12-27
申请号：US14499736
申请日：2014-09-29
申请人： GALPHARMA CO., LTD.
IPC分类号： C12N5/078 , A61K35/17 , C12N5/07 , C12N5/0783 , G01N33/68 , A61K49/00 , C12N5/0781 , C12N5/0784 , G01N33/50 , G01N33/569 , C12N5/0786
CPC分类号： G01N33/6893 , A61K35/17 , A61K38/1732 , A61K49/0004 , C07K14/4726 , C12N5/0635 , C12N5/0636 , C12N5/0637 , C12N5/0639 , C12N5/0645 , C12N5/0646 , C12N2501/59 , G01N33/5094 , G01N33/56972 , G01N33/68 , G01N2333/42 , G01N2333/4724 , G01N2333/705
摘要： The object of the present invention is to provide a cell that can exhibit physiological activity based on galectin-9, a method for producing the cell, and use of the cell. In order to achieve the above object, the cell of the present invention contains galectin-9, and the galectin-9 is expressed on a cell surface.
摘要翻译： 本发明的目的是提供一种可以显示基于半乳凝素-9的生理活性的细胞，细胞的制造方法和细胞的使用。 为了实现上述目的，本发明的细胞含有半乳凝素-9，半乳凝素-9在细胞表面表达。
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公开(公告)号：US11912772B2
公开(公告)日：2024-02-27
申请号：US17260077
申请日：2019-07-12
申请人： University of Hawaii
发明人： Lishomwa C. Ndhlovu , Toshiro Niki
CPC分类号： C07K16/2851 , A61K45/06 , A61P35/00 , A61K2039/505
摘要： An antibody targeting Galectin-9 is provided as are methods of using the same treatment of chronic immune conditions such as infections, inflammatory diseases and cancer, in particular malignant mesothelioma.
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公开(公告)号：US09493741B2
公开(公告)日：2016-11-15
申请号：US14499736
申请日：2014-09-29
申请人： GALPHARMA CO., LTD.
IPC分类号： C12N5/078 , A61K35/17 , C12N5/07 , C12N5/0783 , G01N33/68 , A61K49/00 , C12N5/0781 , C12N5/0784 , G01N33/50 , G01N33/569 , C12N5/0786
摘要： The object of the present invention is to provide a cell that can exhibit physiological activity based on galectin-9, a method for producing the cell, and use of the cell. In order to achieve the above object, the cell of the present invention contains galectin-9, and the galectin-9 is expressed on a cell surface.
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