公开(公告)号：US12129221B2

公开(公告)日：2024-10-29

申请号：US17325193

申请日：2021-05-19

申请人： SIRONAX LTD

发明人： Zhiyuan Zhang ,  Yaning Su ,  Yi Yang ,  Guozheng Wang ,  Wendong Liu ,  Yongfen Ma ,  Yan Ren

IPC分类号： C07C233/13 ,  A61P25/28 ,  A61P31/12 ,  A61P35/00

CPC分类号： C07C233/13 ,  A61P25/28 ,  A61P31/12 ,  A61P35/00

摘要： The disclosed compounds inhibit cellular necrosis, and include corresponding sulfonamides, prodrugs and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

公开(公告)号：US12109257B2

公开(公告)日：2024-10-08

申请号：US18045812

申请日：2022-10-11

申请人： Gritstone bio, Inc.

发明人： Wade Blair ,  Karin Jooss ,  Amy Rachel Rappaport ,  Ciaran Daniel Scallan ,  Leonid Gitlin

IPC分类号： A61K39/12 ,  A61K39/00 ,  A61P31/12 ,  C07K14/47 ,  C07K14/74 ,  C12N15/86

CPC分类号： A61K39/001191 ,  A61K39/001188 ,  A61K39/12 ,  A61P31/12 ,  C07K14/4748 ,  C07K14/70539 ,  C12N15/86 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/585 ,  A61K2039/6037 ,  A61K2039/605 ,  A61K2039/70

摘要： Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.

公开(公告)号：US20240325335A1

公开(公告)日：2024-10-03

申请号：US18616966

申请日：2024-03-26

申请人： Alexander E. Michalow ,  Andrew Michalow

发明人： Alexander E. Michalow ,  Andrew Michalow

IPC分类号： A61K31/20 ,  A61K9/00 ,  A61K31/7012 ,  A61K47/54 ,  A61K47/69 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/02 ,  A61P33/10

CPC分类号： A61K31/20 ,  A61K9/0014 ,  A61K9/006 ,  A61K9/0078 ,  A61K31/7012 ,  A61K47/544 ,  A61K47/547 ,  A61K47/6951 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/02 ,  A61P33/10

摘要： A topical aqueous antibiofilm, antimicrobial, and antiviral composition to disrupt biofilm to enhance the killing of microbial and viral particles in a way that prevents and reduces the severity of conditions and infections that are due to such microbial pathogens and viral particles is provided. The composition comprises a fatty acid chosen from saturated and/or unsaturated medium chain fatty acids (MCFAs: C-8 to C-12), saturated and/or unsaturated long chain fatty acids (LCFAs: C-13 to C-26), and/or their derivatives, salts, sugars and esters. The composition also comprises a solubilizing agent, preferably a cyclodextrin, which additionally synergizes the antibiofilm effect, and may be formulated for nebulization/inhalation. The composition further comprises chelating and enhancing agents, and either a neutral, acid or alkaline pH. The composition comprises skin and mucosal permeation enhancers, which improve clinical efficacy. The composition comprises additional antimicrobial and antiviral compounds that can optionally be applied concomitantly.

公开(公告)号：US20240317790A1

公开(公告)日：2024-09-26

申请号：US18410236

申请日：2024-01-11

申请人： Gilead Sciences, Inc.

发明人： Elaine Bunyan ,  Byoung-Kwon Chun ,  Kassibla E. Dempah ,  Hon C Hui ,  Rao V. Kalla ,  Richard L. Mackman

IPC分类号： C07H7/06 ,  A61P31/12

CPC分类号： C07H7/06 ,  A61P31/12 ,  C07B2200/13

摘要： Compounds and methods of using said compounds, singly or in combination with additional agents, and salts, crystalline forms, pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US20240293501A1

公开(公告)日：2024-09-05

申请号：US18002480

申请日：2021-06-21

申请人： Michael J. PAIDAS ,  Arumugam JAYAKUMAR ,  University of Miami

发明人： Michael J. Paidas ,  Arumugam Jayakumar

IPC分类号： A61K38/10 ,  A61P31/12

CPC分类号： A61K38/10 ,  A61P31/12

摘要： This invention provides reagents, pharmaceutical formulations comprising such reagents, and methods for preventing and treating viral infections, specifically coronavirus infections, and in particular infections in humans with COVID-19.

公开(公告)号：US12064407B2

公开(公告)日：2024-08-20

申请号：US16756947

申请日：2018-10-17

申请人： University of Manitoba

发明人： Renée Douville ,  Mamneet Gurm

IPC分类号： A61K31/192 ,  A61K31/352 ,  A61K31/40 ,  A61K31/56 ,  A61P31/12 ,  A61P35/00

CPC分类号： A61K31/192 ,  A61K31/352 ,  A61K31/40 ,  A61K31/56 ,  A61P31/12 ,  A61P35/00

摘要： The present disclosure relates to an endogenous Retrovirus K protein (ERVK) with an alternative envelope protein titled CTXLP. Said CTXLP peptide is represented by the sequences set forth in SEQ ID NO: 1. Additionally, antibodies that specifically recognize the epitope(s) set forth in SEQ ID NO:1 are and methods of use thereof and kits comprising the peptide set forth in SEQ ID NO:1 are also included in the present disclosure.

公开(公告)号：US20240207296A1

公开(公告)日：2024-06-27

申请号：US18600413

申请日：2024-03-08

申请人： MVRIX CO., LTD.

发明人： Woo Jae CHUNG ,  Dae Hyuk Kweon ,  Jinhyo Chung ,  Caleb Hong

IPC分类号： A61K31/7012 ,  A61K47/54 ,  A61P31/12

CPC分类号： A61K31/7012 ,  A61K47/542 ,  A61K47/544 ,  A61K47/549 ,  A61P31/12

摘要： Disclosed is a viral receptor that contains a sialic acid compound at one side thereof to provide binding affinity to a virus, and contains a lipid at the other side thereof, and that can be widely used for the treatment of viral infections based on this characteristic.

公开(公告)号：US12017979B2

公开(公告)日：2024-06-25

申请号：US18112091

申请日：2023-03-23

申请人： ENA Respiratory Pty Ltd

发明人： Ian Holmes ,  Weiguang Zeng ,  David Jackson ,  Christophe Demaison ,  Grant McLachlan

IPC分类号： C07C321/14 ,  A61K47/60 ,  A61K47/64 ,  A61P31/12 ,  C08G65/334

CPC分类号： C07C321/14 ,  A61K47/60 ,  A61K47/64 ,  A61P31/12 ,  C08G65/3348

摘要： The present invention relates to TLR2 agonist compounds and their compositions, and the use of such compounds and compositions in the prevention and/or treatment of respiratory infections, or diseases or conditions associated with viral or bacterial infections.

公开(公告)号：US12010998B2

公开(公告)日：2024-06-18

申请号：US18146628

申请日：2022-12-27

申请人： Chorus, LLC

发明人： Richard S. Rader ,  Kenneth J. Heater ,  Raymond Desabato ,  Daniel P. Lorch ,  Adriane L. Lewis ,  Timothy N. Wells

IPC分类号： A01N59/00 ,  A61L2/20 ,  A61L2/24 ,  A61L9/015 ,  A61L9/14 ,  A61P31/04 ,  A61P31/12 ,  G16H50/20 ,  G16H50/80 ,  G16H70/60 ,  A61L101/06

CPC分类号： A01N59/00 ,  A61L2/20 ,  A61L2/24 ,  A61L9/015 ,  A61L9/14 ,  A61P31/04 ,  A61P31/12 ,  G16H50/20 ,  G16H50/80 ,  G16H70/60 ,  A61L2101/06 ,  A61L2202/11 ,  A61L2202/14 ,  A61L2202/15 ,  A61L2202/25 ,  A61L2209/16

摘要： In one aspect, a system for generating and monitoring an antimicrobial is provided, the system including: a microprocessor and/or a microcontroller; an external communications device; a computational system; an antimicrobial sensor and/or an environmental sensor; and an antimicrobial generator, wherein the external communications device, the computational system, the antimicrobial generator, and the antimicrobial sensor and/or the environmental sensor are operatively connected to the microprocessor and/or the microcontroller. The system may further include a separate sensor sub-system comprising: a sensor sub-system microprocessor and/or a sensor sub-system microcontroller; a sensor sub-system external communications device; a sensor sub-system antimicrobial sensor and/or a sensor sub-system environmental sensor; and a sensor sub-system computational system. The system may further include a separate generation sub-system comprising: a generation sub-system microprocessor and/or a generation sub-system microcontroller; a generation sub-system external communications device; and a generation sub-system antimicrobial generator.

公开(公告)号：US20240189317A1

公开(公告)日：2024-06-13

申请号：US18281942

申请日：2022-03-15

申请人： AI Therapeutics, Inc.

发明人： Peter R. Young ,  Sean Landrette ,  Carlo Spirli ,  Keith Fandrick ,  Murat Gunel

IPC分类号： A61K31/5377 ,  A61K31/245 ,  A61P31/12

CPC分类号： A61K31/5377 ,  A61K31/245 ,  A61P31/12

摘要： The present invention relates to compositions and related methods of using a PIKfyve inhibitor, such as apilimod, in combination with a serine protease inhibitor, for treating or preventing viral disease.