公开(公告)号：US20120136158A1

公开(公告)日：2012-05-31

申请号：US13368397

申请日：2012-02-08

申请人： Brian Nicholas COOK ,  Darren DiSALVO ,  Daniel Robert FANDRICK ,  Christian HARCKEN ,  Daniel KUZMICH ,  Thomas Wai-Ho LEE ,  Pingrong LIU ,  John LORD ,  Can MAO ,  Jochen NEU ,  Brian Christopher RAUDENBUSH ,  Hossein RAZAVI ,  Jonathan Timothy REEVES ,  Jinhua J. SONG ,  Alan David SWINAMER ,  Zhulin TAN

发明人： Brian Nicholas COOK ,  Darren DiSALVO ,  Daniel Robert FANDRICK ,  Christian HARCKEN ,  Daniel KUZMICH ,  Thomas Wai-Ho LEE ,  Pingrong LIU ,  John LORD ,  Can MAO ,  Jochen NEU ,  Brian Christopher RAUDENBUSH ,  Hossein RAZAVI ,  Jonathan Timothy REEVES ,  Jinhua J. SONG ,  Alan David SWINAMER ,  Zhulin TAN

IPC分类号： C07D213/73

CPC分类号： C07D471/04

摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are intermediates thereof, and methods of making and methods of using same.

摘要翻译： 公开了式（I）化合物，其可用于治疗通过包括自身免疫疾病如类风湿性关节炎和多发性硬化的CCR1的活性介导或持续的多种疾病和病症。 还公开了其中间体及其制备方法及其使用方法。

公开(公告)号：US20110086846A1

公开(公告)日：2011-04-14

申请号：US12969753

申请日：2010-12-16

申请人： Brian Nicholas COOK ,  Darren DiSALVO ,  Christian HARCKEN ,  Daniel KUZMICH ,  Thomas Wai-Ho LEE ,  Pingrong LIU ,  John LORD ,  Can MAO ,  Jochen NEU ,  Brian Christopher RAUDENBUSH ,  Hossein RAZAVI ,  Alan David SWINAMER

发明人： Brian Nicholas COOK ,  Darren DiSALVO ,  Christian HARCKEN ,  Daniel KUZMICH ,  Thomas Wai-Ho LEE ,  Pingrong LIU ,  John LORD ,  Can MAO ,  Jochen NEU ,  Brian Christopher RAUDENBUSH ,  Hossein RAZAVI ,  Alan David SWINAMER

IPC分类号： A61K31/541 ,  A61K31/437 ,  A61K31/496 ,  A61K31/5377 ,  A61P19/02 ,  A61P37/08 ,  A61P11/06 ,  A61P25/00 ,  A61P29/00 ,  A61P17/06 ,  A61P3/10 ,  A61P25/28 ,  A61P7/00

CPC分类号： C07D471/04

摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.

摘要翻译： 公开了式（I）化合物，其可用于治疗通过包括自身免疫疾病如类风湿性关节炎和多发性硬化的CCR1的活性介导或持续的多种疾病和病症。 还公开了制备方法和使用方法。

公开(公告)号：US20120035370A1

公开(公告)日：2012-02-09

申请号：US13273509

申请日：2011-10-14

申请人： Brian Nicholas COOK ,  Darren DiSALVO ,  Daniel Robert FANDRICK ,  Christian HARCKEN ,  Daniel KUZMICH ,  Thomas Wai-Ho LEE ,  Pingrong LIU ,  John LORD ,  Can MAO ,  Jochen NEU ,  Brian Christopher RAUDENBUSH ,  Hossein RAZAVI ,  Jonathan Timothy REEVES ,  Jinhua J. SONG ,  Alan David SWINAMER ,  Zhulin TAN

发明人： Brian Nicholas COOK ,  Darren DiSALVO ,  Daniel Robert FANDRICK ,  Christian HARCKEN ,  Daniel KUZMICH ,  Thomas Wai-Ho LEE ,  Pingrong LIU ,  John LORD ,  Can MAO ,  Jochen NEU ,  Brian Christopher RAUDENBUSH ,  Hossein RAZAVI ,  Jonathan Timothy REEVES ,  Jinhua J. SONG ,  Alan David SWINAMER ,  Zhulin TAN

IPC分类号： C07D471/04 ,  C07D213/71

CPC分类号： C07D471/04

摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are intermediates thereof, and methods of making and methods of using same.

摘要翻译： 公开了式（I）化合物，其可用于治疗通过包括自身免疫疾病如类风湿性关节炎和多发性硬化的CCR1的活性介导或持续的多种疾病和病症。 还公开了其中间体及其制备方法及其使用方法。

公开(公告)号：US20100093724A1

公开(公告)日：2010-04-15

申请号：US12564129

申请日：2009-09-22

申请人： Brian Nicholas COOK ,  Darren DiSALVO ,  Daniel Robert FANDRICK ,  Christian HARCKEN ,  Daniel KUZMICH ,  Thomas Wai-Ho LEE ,  Pingrong LIU ,  John LORD ,  Can MAO ,  Jochen NEU ,  Brian Christopher RAUDENBUSH ,  Hossein RAZAVI ,  Jonathan Timothy REEVES ,  Jinhua J. SONG ,  Alan David SWINAMER ,  Zhulin TAN

发明人： Brian Nicholas COOK ,  Darren DiSALVO ,  Daniel Robert FANDRICK ,  Christian HARCKEN ,  Daniel KUZMICH ,  Thomas Wai-Ho LEE ,  Pingrong LIU ,  John LORD ,  Can MAO ,  Jochen NEU ,  Brian Christopher RAUDENBUSH ,  Hossein RAZAVI ,  Jonathan Timothy REEVES ,  Jinhua J. SONG ,  Alan David SWINAMER ,  Zhulin TAN

IPC分类号： A61K31/5377 ,  A61K31/497 ,  A61K31/4353 ,  C07D413/12 ,  C07D471/02

CPC分类号： C07D471/04

摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.

摘要翻译： 公开了式（I）化合物，其可用于治疗通过包括自身免疫疾病如类风湿性关节炎和多发性硬化的CCR1的活性介导或持续的多种疾病和病症。 还公开了制备方法和使用方法。

公开(公告)号：US20120322790A1

公开(公告)日：2012-12-20

申请号：US13328199

申请日：2011-12-16

申请人： Rajashekhar BETAGERI ,  Brian Nicholas COOK ,  Darren DiSALVO ,  Christian HARCKEN ,  Daniel KUZMICH ,  Pingrong LIU ,  John LORD ,  Can MAO ,  Hossein RAZAVI

发明人： Rajashekhar BETAGERI ,  Brian Nicholas COOK ,  Darren DiSALVO ,  Christian HARCKEN ,  Daniel KUZMICH ,  Pingrong LIU ,  John LORD ,  Can MAO ,  Hossein RAZAVI

IPC分类号： A61K31/437 ,  A61K31/444 ,  A61K31/5377 ,  C07D487/04 ,  A61K31/55 ,  A61P29/00 ,  A61P37/08 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P3/10 ,  A61P1/00 ,  A61P1/02 ,  A61P37/06 ,  A61P25/28 ,  A61P11/06 ,  A61P13/12 ,  A61P31/00 ,  A61P37/00 ,  C07D471/04

CPC分类号： C07D471/04 ,  C07D487/04

摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.

摘要翻译： 公开了式（I）化合物，其可用于治疗通过包括自身免疫疾病如类风湿性关节炎和多发性硬化的CCR1的活性介导或持续的多种疾病和病症。 还公开了制备方法和使用方法。