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21 条记录 (耗时 0.015 秒)

    Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
    2.
    发明授权
    Stereoselective synthesis of certain trifluoromethyl-substituted alcohols 有权
    某些三氟甲基取代的醇的立体选择性合成

    公开(公告)号：US07507843B2

    公开(公告)日：2009-03-24

    申请号：US10955165

    申请日：2004-09-30

    申请人： Jinhua J. Song ,  Zhulin Tan ,  Jinghua Xu ,  Nathan K. Yee ,  Chris H. Senanayake

    发明人： Jinhua J. Song ,  Zhulin Tan ,  Jinghua Xu ,  Nathan K. Yee ,  Chris H. Senanayake

    IPC分类号： C07D301/27

    CPC分类号： C07D303/22

    摘要： A process for stereoselective synthesis of compounds of Formula X wherein: R1 is an aryl or heteroaryl group, each optionally independently substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl, C1-C5 alkoxy, C2-C5 alkenyloxy, C2-C5 alkynyloxy, aryloxy, C1-C5 alkanoyloxy, C1-C5 alkanoyl, aroyl, trifluoromethyl, trifluoromethoxy, or C1-C5 alkylthio, wherein each substituent group of R1 is optionally independently substituted with one to three substituent groups selected from methyl, methoxy, fluoro, chloro, hydroxy, oxo, cyano, or amino; and R2 and R3 are each independently hydrogen or C1-C5 alkyl, or R2 and R3 together with the carbon atom they are commonly attached to form a C3-C8 spiro cycloalkyl ring.

    摘要翻译： 用于立体选择性合成式X化合物的方法，其中：R 1是芳基或杂芳基，各自任选地独立地被1至3个取代基取代，其中R 1的每个取代基独立地是C 1 -C 5烷基，C 2 -C 5烯基，C 2 -C 5炔基，C 3 -C 8环烷基，杂环基，芳基，杂芳基，C 1 -C 5烷氧基，C 2 -C 5烯氧基，C 2 -C 5炔氧基，芳氧基，C 1 -C 5烷酰氧基，C 1 -C 5烷酰基，芳酰基，三氟甲基，三氟甲氧基或C 1 -C 5烷硫基，其中R 1的每个取代基任选地被一至三个选自甲基，甲氧基，氟，氯，羟基，氧代，氰基或氨基的取代基独立地取代。 并且R 2和R 3各自独立地为氢或C 1 -C 5烷基，或者R 2和R 3与它们通常连接的碳原子一起形成C 3 -C 8螺环烷基环。

    2-OXO-1,2-DIHYDROPYRIDIN-4-YLBORONIC ACID DERIVATIVES
    4.
    发明申请
    2-OXO-1,2-DIHYDROPYRIDIN-4-YLBORONIC ACID DERIVATIVES 失效
    2-氧代-1,2-二氢吡啶-4-基硼酸衍生物

    公开(公告)号：US20130203985A1

    公开(公告)日：2013-08-08

    申请号：US13697862

    申请日：2011-05-23

    申请人： Zhulin Tan

    发明人： Zhulin Tan

    IPC分类号： C07F5/02 ,  C07D413/10

    CPC分类号： C07F5/025 ,  C07D413/10

    摘要： The present invention relates to a compound of formula (I) wherein R1, R2 and n are as defined herein. The invention also relates to processes for making the compounds of formula (I) and methods of using the compounds of formula (I) as reagents in organic synthesis.

    摘要翻译： 本发明涉及其中R 1，R 2和n如本文所定义的式（I）化合物。 本发明还涉及制备式（I）化合物的方法和使用式（I）化合物作为有机合成中的试剂的方法。

    Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
    6.
    发明申请
    Stereoselective synthesis of certain trifluoromethyl-substituted alcohols 有权
    某些三氟甲基取代的醇的立体选择性合成

    公开(公告)号：US20050131241A1

    公开(公告)日：2005-06-16

    申请号：US10955165

    申请日：2004-09-30

    申请人： Jinhua Song ,  Zhulin Tan ,  Jinghua Xu ,  Nathan Yee ,  Chris Senanayake

    发明人： Jinhua Song ,  Zhulin Tan ,  Jinghua Xu ,  Nathan Yee ,  Chris Senanayake

    IPC分类号： C07D301/27 ,  C07D303/22 ,  C07F3/04

    CPC分类号： C07D303/22

    摘要： A process for stereoselective synthesis of compounds of Formula X wherein: R1 is an aryl or heteroaryl group, each optionally independently substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl, C1-C5 alkoxy, C2-C5 alkenyloxy, C2-C5 alkynyloxy, aryloxy, C1-C5 alkanoyloxy, C1-C5 alkanoyl, aroyl, trifluoromethyl, trifluoromethoxy, or C1-C5 alkylthio, wherein each substituent group of R1 is optionally independently substituted with one to three substituent groups selected from methyl, methoxy, fluoro, chloro, hydroxy, oxo, cyano, or amino; and R2 and R3 are each independently hydrogen or C1-C5 alkyl, or R2 and R3 together with the carbon atom they are commonly attached to form a C3-C8 spiro cycloalkyl ring.

    摘要翻译： 用于立体选择性合成式X化合物的方法，其中：R 1是芳基或杂芳基，每个任选地独立地被一至三个取代基取代，其中R 1， / SUP>独立地为C 1 -C 5烷基，C 2 -C 5链烯基，C 2和R 3与它们通常连接的碳原子一起形成C 3 -C 8 - 螺环烷基环 。

    2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives
    8.
    发明授权
    2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives 失效
    2-氧代-1,2-二氢吡啶-4-基硼酸衍生物

    公开(公告)号：US08648192B2

    公开(公告)日：2014-02-11

    申请号：US13697862

    申请日：2011-05-23

    申请人： Zhulin Tan

    发明人： Zhulin Tan

    IPC分类号： C07F5/02

    CPC分类号： C07F5/025 ,  C07D413/10

    摘要： The present invention relates to a compound of formula (I) wherein R1, R2 and n are as defined herein. The invention also relates to processes for making the compounds of formula (I) and methods of using the compounds of formula (I) as reagents in organic synthesis.

    摘要翻译： 本发明涉及其中R 1，R 2和n如本文所定义的式（I）化合物。 本发明还涉及制备式（I）化合物的方法和使用式（I）化合物作为有机合成中的试剂的方法。

    STEROSELECTIVE SYNTHESIS OF CERTAIN TRIFLUOROMETHYL-SUBSTITUTED ALCOHOLS
    10.
    发明申请
    STEROSELECTIVE SYNTHESIS OF CERTAIN TRIFLUOROMETHYL-SUBSTITUTED ALCOHOLS 审中-公开
    某些三氟甲磺酸取代的醇的取代合成

    公开(公告)号：US20110130567A1

    公开(公告)日：2011-06-02

    申请号：US12788552

    申请日：2010-05-27

    申请人： DANIEL R. FANDRICK ,  JONATHAN T. REEVES ,  JINHUA J. SONG ,  ZHULIN TAN ,  BO QU ,  NATHAN K. YEE ,  SONIA RODRIGUEZ

    发明人： DANIEL R. FANDRICK ,  JONATHAN T. REEVES ,  JINHUA J. SONG ,  ZHULIN TAN ,  BO QU ,  NATHAN K. YEE ,  SONIA RODRIGUEZ

    IPC分类号： C07D471/04

    CPC分类号： C07D401/04 ,  C07B2200/07

    摘要： A process for stereoselective synthesis of a compound of Formula (X) wherein: R1 is an aryl group substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromethyl, wherein each substituent group of R1 is optionally independently substituted with one to three substituents selected from C1-C3 alkyl, C1-C3 alkoxy, phenyl, and alkoxyphenyl; R2 and R3 are each independently C1-C5 alkyl; R4 is C1-C5 alkyl optionally independently substituted with one to three substituent groups, wherein each substituent group of R4 is independently C1-C3 alkyl, hydroxy, halogen, amino, or oxo; and R5 is a heteroaryl group substituted with one to three substituent groups, wherein each substituent group of R5 is independently C1-C5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylsulfonylamino, aminosulfonyl, C1-C5 alkylaminosulfonyl, C1-C5 dialkylaminosulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, or C1-C5 alkylthio wherein the sulfur atom is optionally oxidized to a sulfoxide or sulfone.

    摘要翻译： 一种用于立体选择性合成式（X）化合物的方法，其中：R 1是被1至3个取代基取代的芳基，其中R 1的每个取代基独立地是C 1 -C 5烷基，氨基羰基，烷基氨基羰基，二烷基氨基羰基，卤素，羧基 氰基或三氟甲基，其中R 1的每个取代基任选地独立地被1-3个选自C 1 -C 3烷基，C 1 -C 3烷氧基，苯基和烷氧基苯基的取代基取代; R2和R3各自独立地为C1-C5烷基; R4是任选独立地被1至3个取代基取代的C 1 -C 5烷基，其中R 4的每个取代基独立地是C 1 -C 3烷基，羟基，卤素，氨基或氧代; R5是被一至三个取代基取代的杂芳基，其中R 5的每个取代基独立地是C 1 -C 5烷基，氨基羰基，烷基氨基羰基，二烷基氨基羰基，烷基磺酰基氨基，氨基磺酰基，C 1 -C 5烷基氨基磺酰基，C 1 -C 5二烷基氨基磺酰基，卤素，羟基 ，羧基，氰基，三氟甲基，三氟甲氧基，三氟甲硫基或C 1 -C 5烷硫基，其中硫原子任选被氧化成亚砜或砜。