公开(公告)号：US09227014B2

公开(公告)日：2016-01-05

申请号：US14175020

申请日：2014-02-07

申请人： Bruce A. Buckingham ,  B. Wayne Bequette ,  Fraser Cameron ,  Darrell M. Wilson ,  H. Peter Chase ,  Francis J. Doyle, III ,  Matthew Stenerson

发明人： Bruce A. Buckingham ,  B. Wayne Bequette ,  Fraser Cameron ,  Darrell M. Wilson ,  H. Peter Chase ,  Francis J. Doyle, III ,  Matthew Stenerson

IPC分类号： A61M5/172 ,  A61M5/142

CPC分类号： A61M5/1723 ,  A61M5/14244 ,  A61M2005/14296 ,  A61M2205/332 ,  A61M2230/005 ,  A61M2230/06 ,  A61M2230/201 ,  A61M2230/63

摘要： Techniques for controlling an insulin pump include determining values for parameters selected from a group including a first prediction time horizon, a predicted glucose threshold (Goff) for turning the insulin pump off, a maximum shut off time within a time window, and duration of the time window. A safety rule is determined based on the maximum shut off time within the duration. Glucose readings are collected up to a current time. An expected current glucose value G and glucose temporal rate of change are determined based only on the glucose readings and a Kalman filter configured for noisy glucose readings. A glucose level (Gh1) is predicted for a future time that is the prediction time horizon after the current time. A command is issued to shut off the insulin pump if it is determined both that Gh1 is less than Goff and that the safety rule is satisfied.

摘要翻译： 用于控制胰岛素泵的技术包括确定从包括第一预测时间范围，用于使胰岛素泵关闭的预测葡萄糖阈值（Goff），时间窗口内的最大关闭时间和 时间窗口 基于持续时间内的最大关闭时间确定安全规则。 葡萄糖读数至目前为止收集。 仅基于葡萄糖读数和配置用于噪声葡萄糖读数的卡尔曼滤波器来确定预期的当前葡萄糖值G和葡萄糖时间变化率。 在未来时间预测葡萄糖水平（Gh1），该时间是当前时间之后的预测时间范围。 如果确定Gh1小于Goff，并且满足安全规则，则发出关闭胰岛素泵的命令。

公开(公告)号：US20140221966A1

公开(公告)日：2014-08-07

申请号：US14175020

申请日：2014-02-07

申请人： Bruce A. Buckingham ,  B. Wayne Bequette ,  Fraser Cameron ,  Darrell M. Wilson ,  H. Peter Chase ,  Francis J. Doyle, III ,  Matthew Stenerson

发明人： Bruce A. Buckingham ,  B. Wayne Bequette ,  Fraser Cameron ,  Darrell M. Wilson ,  H. Peter Chase ,  Francis J. Doyle, III ,  Matthew Stenerson

IPC分类号： A61M5/172

CPC分类号： A61M5/1723 ,  A61M5/14244 ,  A61M2005/14296 ,  A61M2205/332 ,  A61M2230/005 ,  A61M2230/06 ,  A61M2230/201 ,  A61M2230/63

摘要： Techniques for controlling an insulin pump include determining values for parameters selected from a group including a first prediction time horizon, a predicted glucose threshold (Goff) for turning the insulin pump off, a maximum shut off time within a time window, and duration of the time window. A safety rule is determined based on the maximum shut off time within the duration. Glucose readings are collected up to a current time. An expected current glucose value G and glucose temporal rate of change are determined based only on the glucose readings and a Kalman filter configured for noisy glucose readings. A glucose level (Gh1) is predicted for a future time that is the prediction time horizon after the current time. A command is issued to shut off the insulin pump if it is determined both that Gh1 is less than Goff and that the safety rule is satisfied.

摘要翻译： 用于控制胰岛素泵的技术包括确定从包括第一预测时间范围，用于使胰岛素泵关闭的预测葡萄糖阈值（Goff），时间窗口内的最大关闭时间和 时间窗口 基于持续时间内的最大关闭时间确定安全规则。 葡萄糖读数至目前为止收集。 仅基于葡萄糖读数和配置用于噪声葡萄糖读数的卡尔曼滤波器来确定预期的当前葡萄糖值G和葡萄糖时间变化率。 在未来时间预测葡萄糖水平（Gh1），该时间是当前时间之后的预测时间范围。 如果确定Gh1小于Goff，并且满足安全规则，则发出关闭胰岛素泵的命令。

公开(公告)号：US06572545B2

公开(公告)日：2003-06-03

申请号：US09960855

申请日：2001-09-21

申请人： Edward J. Knobbe ,  Wah L. Lim ,  Bruce A. Buckingham

发明人： Edward J. Knobbe ,  Wah L. Lim ,  Bruce A. Buckingham

IPC分类号： A61B500

CPC分类号： A61B5/0002 ,  A61B5/14532 ,  A61B5/725 ,  A61B2560/0242 ,  A61M5/142 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3456 ,  G06F19/3481 ,  G16H10/40 ,  G16H50/50 ,  Y02A90/26 ,  Y10S128/923 ,  Y10S128/924

摘要： A real-time controller operating as an artificial pancreas uses a Kalman control algorithm to control glucose level of a patient in real time. The real-time controller receives an estimate of the patient glucose level and a reference glucose level. The estimate of the patient glucose level can be provided by an optimal estimator implemented using a linearized Kalman filter. The estimated glucose level and the reference glucose level are processed by the Kalman control algorithm to determine a control command in real time. The Kalman control algorithm has a dynamic process forced by the control command a cost function determining a relative level of control. The control command is provided to a dispenser which secretes insulin or glucagon in response to the control command to correct a relatively high glucose level or a relatively low glucose level.

公开(公告)号：US06575905B2

公开(公告)日：2003-06-10

申请号：US09960846

申请日：2001-09-21

申请人： Edward J. Knobbe ,  Wah L. Lim ,  Bruce A. Buckingham

发明人： Edward J. Knobbe ,  Wah L. Lim ,  Bruce A. Buckingham

IPC分类号： A61B500

CPC分类号： A61B5/0002 ,  A61B5/14532 ,  A61B5/725 ,  A61B2560/0242 ,  A61M5/142 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3456 ,  G06F19/3481 ,  G16H10/40 ,  G16H50/50 ,  Y02A90/26 ,  Y10S128/923 ,  Y10S128/924

摘要： A real-time glucose estimator uses a linearized Kalman filter to determine a best estimate of glucose level in real time. The real-time glucose estimator receives at least one measurement corresponding to glucose level. The measurement can be obtained with one or more sensors and is provided to the linearized Kalman filter in real time. The linearized Kalman filter has dynamic models and executes a recursive routine to determine the best estimate of glucose level based upon the measurement. Additional information can be provided to the linearized Kalman filter for initialization, configuration, and the like. Outputs of the linearized Kalman filter can be provided to a patient health monitor for display or for statistical testing to determine status of the real-time glucose estimator. The real-time glucose estimator can be implemented using a software algorithm.