Patent search ap:("Celtaxsys Page Inc.") AND inv:"David Davey"

1.

发明申请
INHIBITORS OF LEUKOTRIENE A4 HYDROLASE 审中-公开

公开(公告)号：US20180118735A1

公开(公告)日：2018-05-03

申请号：US15801494

申请日：2017-11-02

Applicant: Celtaxsys, Inc.

Inventor： William Guilford , David Davey

IPC: C07D417/14 , C07D401/14 , C07C217/58 , C07D401/04 , C07D405/14 , C07D413/14 , C07D213/74 , C07D401/12 , C07D403/14 , C07D413/12 , C07D417/12 , C07D211/60 , C07D213/62 , C07D213/64 , C07C229/38

CPC classification number: C07D417/14 , C07C217/58 , C07C229/38 , C07D211/60 , C07D213/62 , C07D213/64 , C07D213/74 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12

Abstract: The present invention is directed to compounds encompassed by the Formula (I), pharmaceutical compositions thereof, methods for inhibiting LTA-4 hydrolase, and methods for the treatment of a disease and disorder which is ameliorated by the inhibition of LTA4-h activity. Non-limiting examples of such diseases and conditions include inflammatory and autoimmune diseases and disorders.

2.

发明申请
DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE 有权
Title translation: 作为LEUKOTRIENE A4水解酶抑制剂的DIAMINE衍生物

公开(公告)号：US20150080382A1

公开(公告)日：2015-03-19

申请号：US14313672

申请日：2014-06-24

Applicant: Celtaxsys, Inc.

Inventor： Damian O. Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J. Kochanny , Amy Liang , David Light , John Parkinson , Guo Ping Wei , Bin Ye

IPC: C07D487/08 , C07D243/08 , C07C229/08 , C07D409/12 , C07D401/12 , C07D263/14 , C07D405/12

CPC classification number: C07D487/08 , C07B2200/07 , C07C217/58 , C07C229/08 , C07C229/38 , C07C233/78 , C07C255/57 , C07C271/20 , C07C2601/14 , C07D207/04 , C07D207/09 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/58 , C07D243/08 , C07D263/14 , C07D263/32 , C07D277/22 , C07D277/68 , C07D295/04 , C07D295/096 , C07D295/16 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/02 , C07D451/04

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

Abstract translation: 本发明涉及式（I）化合物：其中r，q，R，R2，R3，R4，R5a，R5b，R5c，R6a，R6b，R6c，R7，R8和R9在本文中描述为单立体异构体或作为立体异构体或其药学上可接受的盐，溶剂合物，包合物，多晶型物，铵离子，N-氧化物或前药的混合物; 其是白三烯A4水解酶抑制剂，因此可用于治疗炎症性疾病。还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。

3.

发明申请
DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE 审中-公开

公开(公告)号：US20200308181A1

公开(公告)日：2020-10-01

申请号：US16738190

申请日：2020-01-09

Applicant: Celtaxsys, Inc.

Inventor： Damian O. Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J. Kochanny , Amy Liang , David Light , John Parkinson , Guo Ping Wei , Bin Ye

IPC: C07D487/08 , C07C217/58 , C07C229/38 , C07C233/78 , C07C255/57 , C07C271/20 , C07D207/04 , C07D211/58 , C07D243/08 , C07D295/04 , C07D295/16 , C07D451/04 , C07D207/09 , C07D211/26 , C07D263/32 , C07D295/096 , C07D401/10 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07C229/08 , C07D263/14 , C07D401/12 , C07D207/16 , C07D211/34 , C07D277/22 , C07D277/68 , C07D451/02

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

4.

发明授权
Inhibitors of leukotriene A4 hydrolase 有权

公开(公告)号：US09822106B2

公开(公告)日：2017-11-21

申请号：US14849829

申请日：2015-09-10

Applicant: Celtaxsys, Inc.

Inventor： William Guilford , David Davey

IPC: C07D417/14 , C07D401/04 , C07D405/14 , C07D413/14 , C07D213/74 , C07D401/12 , C07D403/14 , C07D413/12 , C07D417/12 , C07D211/60 , C07D213/62 , C07C217/58 , C07C229/38 , C07D213/64 , C07D401/14

CPC classification number: C07D417/14 , C07C217/58 , C07C229/38 , C07D211/60 , C07D213/62 , C07D213/64 , C07D213/74 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12

Abstract: The present invention is directed to compounds encompassed by the Formula (I), pharmaceutical compositions thereof, methods for inhibiting LTA-4 hydrolase, and methods for the treatment of a disease and disorder which is ameliorated by the inhibition of LTA4-h activity. Non-limiting examples of such diseases and conditions include inflammatory and autoimmune diseases and disorders.

5.

发明申请
DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE 审中-公开

公开(公告)号：US20180230159A1

公开(公告)日：2018-08-16

申请号：US15891585

申请日：2018-02-08

Applicant: Celtaxsys, Inc.

Inventor： Damian O. Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J. Kochanny , Amy Liang , David Light , John Parkinson , Guo Ping Wei , Bin Ye

IPC: C07D487/08 , C07D263/32 , C07C271/20 , C07D211/58 , C07C229/38 , C07C229/08 , C07D295/096 , C07C255/57 , C07D211/34 , C07D207/04 , C07D401/12 , C07D243/08 , C07D295/16 , C07D295/04 , C07D451/04 , C07D277/68 , C07D401/10 , C07C217/58 , C07D207/09 , C07D405/12 , C07D403/12 , C07D409/12 , C07D211/26 , C07D413/12 , C07D451/02 , C07D277/22 , C07C233/78 , C07D263/14 , C07D207/16

CPC classification number: C07D487/08 , C07B2200/07 , C07C217/58 , C07C229/08 , C07C229/38 , C07C233/78 , C07C255/57 , C07C271/20 , C07C2601/14 , C07D207/04 , C07D207/09 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/58 , C07D243/08 , C07D263/14 , C07D263/32 , C07D277/22 , C07D277/68 , C07D295/04 , C07D295/096 , C07D295/16 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/02 , C07D451/04

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

6.

发明申请
INHIBITORS OF LEUKOTRIENE A4 HYDROLASE 有权

公开(公告)号：US20160068522A1

公开(公告)日：2016-03-10

申请号：US14849829

申请日：2015-09-10

Applicant: Celtaxsys, Inc.

Inventor： William Guilford , David Davey

IPC: C07D417/14 , C07D401/04 , C07D213/64 , C07D413/12 , C07D401/14 , C07D417/12 , C07D401/12 , C07D413/14 , C07D405/14 , C07D213/74 , C07C229/38

CPC classification number: C07D417/14 , C07C217/58 , C07C229/38 , C07D211/60 , C07D213/62 , C07D213/64 , C07D213/74 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12

Abstract: The present invention is directed to compounds encompassed by the Formula (I), pharmaceutical compositions thereof, methods for inhibiting LTA-4 hydrolase, and methods for the treatment of a disease and disorder which is ameliorated by the inhibition of LTA4-h activity. Non-limiting examples of such diseases and conditions include inflammatory and autoimmune diseases and disorders.

7.

发明申请
DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE 审中-公开
Title translation: 作为LEUKOTRIENE A4水解酶抑制剂的DIAMINE衍生物

公开(公告)号：US20160272649A1

公开(公告)日：2016-09-22

申请号：US15069484

申请日：2016-03-14

Applicant: Celtaxsys, Inc.

Inventor： Damian O. Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J. Kochanny , Amy Liang , David Light , John Parkinson , Guo Ping Wei , Bin Ye

IPC: C07D487/08 , C07D263/32 , C07D211/58 , C07D277/22 , C07D207/09 , C07D207/16 , C07D451/02 , C07D277/68 , C07D295/16 , C07D211/34

CPC classification number: C07D487/08 , C07B2200/07 , C07C217/58 , C07C229/08 , C07C229/38 , C07C233/78 , C07C255/57 , C07C271/20 , C07C2601/14 , C07D207/04 , C07D207/09 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/58 , C07D243/08 , C07D263/14 , C07D263/32 , C07D277/22 , C07D277/68 , C07D295/04 , C07D295/096 , C07D295/16 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/02 , C07D451/04

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

Abstract translation: 其中r，q，R，R2，R3，R4，R5a，R5b，R5c，R6a，R6b，R6c，R6a，R6b，R6c，R7，R8和R9在本文中作为单一立体异构体或立体异构体的混合物或其药学上可接受的盐，溶剂合物，包合物，多晶型物，铵离子，N-氧化物或前药; 其是白三烯A4水解酶抑制剂，因此可用于治疗炎症性疾病。还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。