公开(公告)号：US07252945B2

公开(公告)日：2007-08-07

申请号：US10992407

申请日：2004-11-18

申请人： Christophe P. G. Gerald ,  Kenneth A. Jones ,  James A. Bonini ,  Beth E. Borowsky ,  Douglas A. Craig

发明人： Christophe P. G. Gerald ,  Kenneth A. Jones ,  James A. Bonini ,  Beth E. Borowsky ,  Douglas A. Craig

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12N15/00

CPC分类号： C07K14/70571 ,  A01K2217/075

摘要： This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.

公开(公告)号：US06849727B1

公开(公告)日：2005-02-01

申请号：US09538036

申请日：2000-03-29

申请人： Christophe P. G. Gerald ,  Kenneth A. Jones ,  James A. Bonini ,  Beth E. Borowsky ,  Douglas A. Craig

发明人： Christophe P. G. Gerald ,  Kenneth A. Jones ,  James A. Bonini ,  Beth E. Borowsky ,  Douglas A. Craig

IPC分类号： C07K14/705 ,  C12N15/12 ,  C07H21/04 ,  C07K14/00 ,  C12N15/00 ,  C12N15/63

CPC分类号： C07K14/70571 ,  A01K2217/075

摘要： This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.

摘要翻译： 本发明提供编码哺乳动物NPFF受体的分离的核酸，纯化的哺乳动物NPFF受体，包含编码哺乳动物NPFF受体的核酸的载体，包含该载体的细胞，针对哺乳动物NPFF受体的抗体，用于检测编码哺乳动物NPFF受体的核酸的核酸探针， 与编码哺乳动物NPFF受体的核酸的独特序列互补的反义寡核苷酸，其表达编码正常或突变型哺乳动物NPFF受体的DNA的转基因非人动物，分离哺乳动物NPFF受体的方法，治疗与哺乳动物活性相关的异常的方法 NPFF受体，以及确定化合物与哺乳动物NPFF受体的结合的方法，识别NPFF受体的激动剂和拮抗剂的方法，以及如此鉴定的激动剂和拮抗剂。

公开(公告)号：US07276339B2

公开(公告)日：2007-10-02

申请号：US10992577

申请日：2004-11-18

申请人： Christophe P. G. Gerald ,  Kenneth A. Jones ,  James A. Bonini ,  Beth E. Borowsky ,  Douglas A. Craig

发明人： Christophe P. G. Gerald ,  Kenneth A. Jones ,  James A. Bonini ,  Beth E. Borowsky ,  Douglas A. Craig

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12N15/00

CPC分类号： C07K14/70571 ,  A01K2217/075

摘要： This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.

摘要翻译： 本发明提供编码哺乳动物NPFF受体的分离的核酸，纯化的哺乳动物NPFF受体，包含编码哺乳动物NPFF受体的核酸的载体，包含该载体的细胞，针对哺乳动物NPFF受体的抗体，用于检测编码哺乳动物NPFF受体的核酸的核酸探针， 与编码哺乳动物NPFF受体的核酸的独特序列互补的反义寡核苷酸，其表达编码正常或突变型哺乳动物NPFF受体的DNA的转基因非人动物，分离哺乳动物NPFF受体的方法，治疗与哺乳动物活性相关的异常的方法 NPFF受体，以及确定化合物与哺乳动物NPFF受体的结合的方法，识别NPFF受体的激动剂和拮抗剂的方法，以及如此鉴定的激动剂和拮抗剂。

公开(公告)号：US06709831B1

公开(公告)日：2004-03-23

申请号：US09405558

申请日：1999-09-24

申请人： Christophe P. G. Gerald ,  Kenneth A. Jones ,  James A. Bonini ,  Beth E. Borowsky ,  Douglas A. Craig

发明人： Christophe P. G. Gerald ,  Kenneth A. Jones ,  James A. Bonini ,  Beth E. Borowsky ,  Douglas A. Craig

IPC分类号： G01N33566

CPC分类号： C07K14/70571 ,  A01K2217/075

摘要： This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.

摘要翻译： 本发明提供编码哺乳动物NPFF受体的分离的核酸，纯化的哺乳动物NPFF受体，包含编码哺乳动物NPFF受体的核酸的载体，包含该载体的细胞，针对哺乳动物NPFF受体的抗体，用于检测编码哺乳动物NPFF受体的核酸的核酸探针， 与编码哺乳动物NPFF受体的核酸的独特序列互补的反义寡核苷酸，其表达编码正常或突变型哺乳动物NPFF受体的DNA的转基因非人动物，分离哺乳动物NPFF受体的方法，治疗与哺乳动物活性相关的异常的方法 NPFF受体，以及确定化合物与哺乳动物NPFF受体的结合的方法，识别NPFF受体的激动剂和拮抗剂的方法，以及如此鉴定的激动剂和拮抗剂。

公开(公告)号：US06468756B1

公开(公告)日：2002-10-22

申请号：US09641259

申请日：2000-08-17

申请人： James A. Bonini ,  Beth E. Borowsky ,  Nika Adham ,  Noel Boyle ,  Thelma O. Thompson

发明人： James A. Bonini ,  Beth E. Borowsky ,  Nika Adham ,  Noel Boyle ,  Thelma O. Thompson

IPC分类号： G01N3353

CPC分类号： C07K14/705

摘要： This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF25 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF25 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF25 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF25 receptors, methods of isolating mammalian SNORF25 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF25 receptors, as well as methods of determining binding of compounds to mammalian SNORF25 receptors, methods of identifying agonists and antagonists of SNORF25 receptors, and agonists and antagonists so identified.

摘要翻译： 本发明提供了编码哺乳动物SNORF25受体的分离的核酸，纯化的哺乳动物SNORF25受体，包含编码哺乳动物SNORF25受体的核酸的载体，包含此类载体的细胞，针对哺乳动物SNORF25受体的抗体，用于检测编码哺乳动物SNORF25受体的核酸的核酸探针， 与编码哺乳动物SNORF25受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变的哺乳动物SNORF25受体的DNA的转基因非人动物，分离哺乳动物SNORF25受体的方法，治疗与哺乳动物的活性相关的异常的方法 SNORF25受体以及确定化合物与哺乳动物SNORF25受体的结合的方法，识别SNORF25受体的激动剂和拮抗剂的方法，以及如此鉴定的激动剂和拮抗剂。

公开(公告)号：US07416848B2

公开(公告)日：2008-08-26

申请号：US10278437

申请日：2002-10-22

申请人： James A. Bonini ,  Beth E. Borowsky ,  Nika Adham ,  Noel Boyle ,  Thelma O. Thompson

发明人： James A. Bonini ,  Beth E. Borowsky ,  Nika Adham ,  Noel Boyle ,  Thelma O. Thompson

IPC分类号： G01N33/53 ,  C07K14/705 ,  C07H21/04

CPC分类号： C07K14/705

摘要： This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF25 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF25 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF25 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF25 receptors, methods of isolating mammalian SNORF25 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF25 receptors, as well as methods of determining binding of compounds to mammalian SNORF25 receptors, methods of identifying agonists and antagonists of SNORF25 receptors, and agonists and antagonists so identified.

摘要翻译： 本发明提供了编码哺乳动物SNORF25受体的分离的核酸，纯化的哺乳动物SNORF25受体，包含编码哺乳动物SNORF25受体的核酸的载体，包含此类载体的细胞，针对哺乳动物SNORF25受体的抗体，用于检测编码哺乳动物SNORF25受体的核酸的核酸探针， 与编码哺乳动物SNORF25受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变的哺乳动物SNORF25受体的DNA的转基因非人动物，分离哺乳动物SNORF25受体的方法，治疗与哺乳动物的活性相关的异常的方法 SNORF25受体以及确定化合物与哺乳动物SNORF25受体的结合的方法，识别SNORF25受体的激动剂和拮抗剂的方法，以及如此鉴定的激动剂和拮抗剂。

公开(公告)号：US06221660B1

公开(公告)日：2001-04-24

申请号：US09387699

申请日：1999-08-13

申请人： James A. Bonini ,  Beth E. Borowsky ,  Nika Adham ,  Noel Boyle ,  Thelma O. Thompson

发明人： James A. Bonini ,  Beth E. Borowsky ,  Nika Adham ,  Noel Boyle ,  Thelma O. Thompson

IPC分类号： C12N518

CPC分类号： C07K14/705

摘要： This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF25 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF25 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF25 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF25 receptors, methods of isolating mammalian SNORF25 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF25 receptors, as well as methods of determining binding of compounds to mammalian SNORF25 receptors, methods of identifying agonists and antagonists of SNORF25 receptors, and agonists and antagonists so identified.

摘要翻译： 本发明提供了编码哺乳动物SNORF25受体的分离的核酸，纯化的哺乳动物SNORF25受体，包含编码哺乳动物SNORF25受体的核酸的载体，包含此类载体的细胞，针对哺乳动物SNORF25受体的抗体，用于检测编码哺乳动物SNORF25受体的核酸的核酸探针， 与编码哺乳动物SNORF25受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变的哺乳动物SNORF25受体的DNA的转基因非人动物，分离哺乳动物SNORF25受体的方法，治疗与哺乳动物的活性相关的异常的方法 SNORF25受体以及确定化合物与哺乳动物SNORF25受体的结合的方法，识别SNORF25受体的激动剂和拮抗剂的方法，以及如此鉴定的激动剂和拮抗剂。

公开(公告)号：US6117990A

公开(公告)日：2000-09-12

申请号：US286805

申请日：1999-04-06

申请人： James A. Bonini ,  Beth E. Borowsky

发明人： James A. Bonini ,  Beth E. Borowsky

IPC分类号： C07K14/705 ,  C12N15/12

CPC分类号： C07K14/705

摘要： This invention provides a recombinant nucleic acid comprising a nucleic acid encoding a mammalian SNORF1 receptor, wherein the mammalian receptor-encoding nucleic acid hybridizes under high stringency conditions to (a) a nucleic acid encoding a human SNORF1 receptor and having a sequence identical to the sequence of the human SNORF1 receptor-encoding nucleic acid contained in plasmid pEXJ-hSNORF1-f (ATCC Accession No. 203898) or (b) a nucleic acid encoding a rat SNORF1 receptor and having a sequence identical to the sequence of the rat SNORF1 receptor-encoding nucleic acid contained in plasmid pcDNA3.1-rSNORF1-f (ATCC Accession No. 203897). This invention further provides a recombinant nucleic acid comprising a nucleic acid encoding a human SNORF1 receptor, wherein the human SNORF1 receptor comprises an amino acid sequence identical to the sequence of the human SNORF1 receptor encoded by the shortest open reading frame indicated in FIGS. 1A-1B (Seq. I.D. No. 1). This invention also provides a recombinant nucleic acid comprising a nucleic acid encoding a rat SNORF1 receptor, wherein the rat SNORF1 receptor comprises an amino acid sequence identical to the sequence of the rat SNORF1 receptor encoded by the shortest open reading frame indicated in FIGS. 3A-3B (Seq. I.D. No. 3).

摘要翻译： 本发明提供了包含编码哺乳动物SNORF1受体的核酸的重组核酸，其中所述哺乳动物受体编码核酸在高严格条件下与（a）编码人类SNORF1受体并具有与序列相同的序列的核酸杂交 的质粒pEXJ-hSNORF1-f（ATCC登录号203898）中包含的人类SNORF1受体编码核酸或（b）编码大鼠SNORF1受体的核酸，并且具有与大鼠SNORF1受体 - 编码质粒pcDNA3.1-rSNORF1-f（ATCC登录号203897）中所含的核酸。 本发明还提供了包含编码人类SNORF1受体的核酸的重组核酸，其中所述人类SNORF1受体包含与由图1和图2所示的最短开放阅读框编码的人类SNORF1受体序列相同的氨基酸序列。 1A-1B（序列号1）。 本发明还提供了包含编码大鼠SNORF1受体的核酸的重组核酸，其中大鼠SNORF1受体包含与图1和图2所示的最短开放阅读框编码的大鼠SNORF1受体序列相同的氨基酸序列。 3A-3B（Seq.I.D.No.3）。

公开(公告)号：US07517658B2

公开(公告)日：2009-04-14

申请号：US11227855

申请日：2005-09-15

申请人： Beth E. Borowsky ,  Kristine L. Ogozalek ,  Kenneth A. Jones

发明人： Beth E. Borowsky ,  Kristine L. Ogozalek ,  Kenneth A. Jones

IPC分类号： G01N33/567 ,  G01N33/53 ,  C07K14/47

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

摘要： This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF33 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF33 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF33 receptors, methods of isolating mammalian SNORF33 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF33 receptors, as well as methods of determining binding of compounds to mammalian SNORF33 receptors, methods of identifying agonists and antagonists of SNORF33 receptors, and agonists and antagonists so identified.

摘要翻译： 本发明提供编码哺乳动物SNORF33受体的分离的核酸，纯化的哺乳动物SNORF33受体，包含编码哺乳动物SNORF33受体的核酸的载体，包含此类载体的细胞，针对哺乳动物SNORF33受体的抗体，用于检测编码哺乳动物SNORF33受体的核酸的核酸探针， 与编码哺乳动物SNORF33受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变的哺乳动物SNORF33受体的DNA的转基因非人动物，分离哺乳动物SNORF33受体的方法，治疗与哺乳动物的活性相关的异常的方法 SNORF33受体以及确定化合物与哺乳动物SNORF33受体的结合的方法，识别SNORF33受体的激动剂和拮抗剂的方法，以及所鉴定的激动剂和拮抗剂。

公开(公告)号：US07371535B2

公开(公告)日：2008-05-13

申请号：US11217710

申请日：2005-09-01

申请人： Beth E. Borowsky ,  Kristine L. Ogozalek ,  Kenneth A. Jones

发明人： Beth E. Borowsky ,  Kristine L. Ogozalek ,  Kenneth A. Jones

IPC分类号： G01N33/566 ,  G01N33/53

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

摘要： This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF33 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF33 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF33 receptors, methods of isolating mammalian SNORF33 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF33 receptors, as well as methods of determining binding of compounds to mammalian SNORF33 receptors, methods of identifying agonists and antagonists of SNORF33 receptors, and agonists and antagonists so identified.

摘要翻译： 本发明提供编码哺乳动物SNORF33受体的分离的核酸，纯化的哺乳动物SNORF33受体，包含编码哺乳动物SNORF33受体的核酸的载体，包含此类载体的细胞，针对哺乳动物SNORF33受体的抗体，用于检测编码哺乳动物SNORF33受体的核酸的核酸探针， 与编码哺乳动物SNORF33受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变的哺乳动物SNORF33受体的DNA的转基因非人动物，分离哺乳动物SNORF33受体的方法，治疗与哺乳动物的活性相关的异常的方法 SNORF33受体以及确定化合物与哺乳动物SNORF33受体的结合的方法，识别SNORF33受体的激动剂和拮抗剂的方法，以及所鉴定的激动剂和拮抗剂。