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1.发明授权公开(公告)号：US07747391B2
公开(公告)日：2010-06-29
申请号：US10629351
申请日：2003-07-29
申请人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
发明人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
摘要翻译： 本发明一般涉及快速有效地搜索生物相关数据空间的方法。 更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。 本发明还提供了对序列活性关系建模的方法。 由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。
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2.发明申请公开(公告)号：US20080133143A1
公开(公告)日：2008-06-05
申请号：US11981577
申请日：2007-10-30
申请人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
发明人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
IPC分类号： G01N33/68
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
摘要翻译： 本发明一般涉及快速有效地搜索生物相关数据空间的方法。 更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。 本发明还提供了对序列活性关系建模的方法。 由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。
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公开(公告)号：US09996661B2
公开(公告)日：2018-06-12
申请号：US12979637
申请日：2010-12-28
申请人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
发明人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
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4.发明申请公开(公告)号：US20110257023A1
公开(公告)日：2011-10-20
申请号：US13168654
申请日：2011-06-24
申请人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
发明人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
摘要翻译： 本发明一般涉及快速有效地搜索生物相关数据空间的方法。 更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。 本发明还提供了对序列活性关系建模的方法。 由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。
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公开(公告)号：US07783428B2
公开(公告)日：2010-08-24
申请号：US10379378
申请日：2003-03-03
申请人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
发明人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
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6.发明授权公开(公告)号：US08849575B2
公开(公告)日：2014-09-30
申请号：US11429628
申请日：2006-05-05
申请人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
发明人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
摘要翻译： 本发明一般涉及快速有效地搜索生物相关数据空间的方法。 更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。 本发明还提供了对序列活性关系建模的方法。 由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。
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7.发明申请公开(公告)号：US20110161265A1
公开(公告)日：2011-06-30
申请号：US12979637
申请日：2010-12-28
申请人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
发明人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
摘要翻译： 本发明一般涉及快速有效地搜索生物相关数据空间的方法。 更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。 本发明还提供了对序列活性关系建模的方法。 由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。
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公开(公告)号：US07751986B2
公开(公告)日：2010-07-06
申请号：US11981577
申请日：2007-10-30
申请人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
发明人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
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9.发明授权Apparatus to obtain flow rates (melt index) in plastics via fixed frequency, pulsed NMR 失效通过固定频率，脉冲NMR获得塑料中的流速（熔体指数）的装置
公开(公告)号：US5367260A
公开(公告)日：1994-11-22
申请号：US961264
申请日：1992-10-15
CPC分类号： G01R33/31 , G01N24/085
摘要： A pulsed NMR analysis system and process comprising an air curtain (137), sample throughput system (P, LI, V1, V2) and user system controls (104) to establish digitized free induction decay curves (C) , from which components functions are determined using linear or nonlinear regression techniques to correlate the curve components to the target nuclei and to flow rates in plastic including MI and FRR for polyethylene and MF for polypropylene.
摘要翻译： 脉冲NMR分析系统和方法，其包括空气幕（137），样品通量系统（P，LI，V1，V2）和用户系统控制（104）以建立数字化的自由感应衰减曲线（C），组分函数 使用线性或非线性回归技术确定曲线分量与目标核的关系，以及包括聚乙烯和MF的聚丙烯的MI和FRR在内的塑料流速。
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10.发明申请MULTI-DIMENSIONAL SPECTRAL ANALYSIS FOR IMPROVED IDENTIFICATION AND CONFIRMATION OF RADIOACTIVE ISOTOPES 审中-公开用于改进放射性同位素鉴定和确认的多维光谱分析公开(公告)号：US20110113003A1
公开(公告)日：2011-05-12
申请号：US12736451
申请日：2009-03-27
申请人： Ajoy K. Roy , Steven A. Sunshine
发明人： Ajoy K. Roy , Steven A. Sunshine
IPC分类号： G06N7/02
CPC分类号： G01N23/00 , G01N2223/01
摘要： A method and system for classifies an unknown sample that contains either a first radioactive isotope, a second radioactive isotope, or a mixture of the first and second radioactive isotopes. Input vectors representative of a training set of samples for a first isotope class and a second isotope class are received. A multivariate classification model is constructed based on the received input vectors. Data is received corresponding to the unknown sample. First and second probabilities that the unknown sample respectively belongs to the first isotope class and the second isotope class are calculated. Based on the first and second probabilities, the unknown sample is classified as either the first radioactive isotope, the second radioactive isotope, or a mixture of the first and second radioactive isotopes.
摘要翻译： 用于分类含有第一放射性同位素，第二放射性同位素或第一和第二放射性同位素的混合物的未知样品的方法和系统。 接收代表第一同位素类和第二同位素类的样本训练集的输入向量。 基于接收的输入向量构建多变量分类模型。 接收对应于未知样本的数据。 未知样品分别属于第一同位素类和第二同位素类的第一和第二概率。 基于第一和第二概率，未知样品被分类为第一放射性同位素，第二放射性同位素或第一和第二放射性同位素的混合物。
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