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1.发明授权公开(公告)号：US07747391B2
公开(公告)日：2010-06-29
申请号：US10629351
申请日：2003-07-29
Applicant: Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
Inventor： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
Abstract: The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
Abstract translation: 本发明一般涉及快速有效地搜索生物相关数据空间的方法。 更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。 本发明还提供了对序列活性关系建模的方法。 由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。
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公开(公告)号：US07629170B2
公开(公告)日：2009-12-08
申请号：US11506215
申请日：2006-08-17
Applicant: Stephen delCardayre , Matthew B. Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy S. Minshull , Phillip A. Patten , Venkiteswatan Mani Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Anthony R. Cox , Gjalt W. Huisman , Ling Yuan , Joseph A. Affholter
Inventor： Stephen delCardayre , Matthew B. Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy S. Minshull , Phillip A. Patten , Venkiteswatan Mani Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Anthony R. Cox , Gjalt W. Huisman , Ling Yuan , Joseph A. Affholter
CPC classification number: C12R1/465 , A01K2267/02 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12N15/90 , C12P17/162 , C12Q1/6811 , C12Q1/6827
Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
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公开(公告)号：US08377681B2
公开(公告)日：2013-02-19
申请号：US13310332
申请日：2011-12-02
Applicant: Stephen DelCardayre , Matthew B. Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy S. Minshull , Phillip A. Patten , Venkiteswatan Mani Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Anthony R. Cox , Gjalt W. Huisman , Ling Yuan , Joseph A. Affholter
Inventor： Stephen DelCardayre , Matthew B. Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy S. Minshull , Phillip A. Patten , Venkiteswatan Mani Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Anthony R. Cox , Gjalt W. Huisman , Ling Yuan , Joseph A. Affholter
CPC classification number: C12N15/102 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12P17/162 , C12Q1/68 , C12Q1/6811 , C12Q1/6827 , C12R1/465
Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
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4.发明申请公开(公告)号：US20080133143A1
公开(公告)日：2008-06-05
申请号：US11981577
申请日：2007-10-30
Applicant: Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
Inventor： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
IPC: G01N33/68
Abstract: The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
Abstract translation: 本发明一般涉及快速有效地搜索生物相关数据空间的方法。 更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。 本发明还提供了对序列活性关系建模的方法。 由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。
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公开(公告)号：US09996661B2
公开(公告)日：2018-06-12
申请号：US12979637
申请日：2010-12-28
Applicant: Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
Inventor： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
Abstract: The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
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Patent Agency Ranking
6.发明授权公开(公告)号：US08076138B2
公开(公告)日：2011-12-13
申请号：US12580056
申请日：2009-10-15
Applicant: Stephen DelCardayre , Matthew B. Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy S. Minshull , Phillip A. Patten , Venkiteswatan Mani Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Anthony R. Cox , Gjalt W. Huisman , Ling Yuan , Joseph A. Affholter
Inventor： Stephen DelCardayre , Matthew B. Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy S. Minshull , Phillip A. Patten , Venkiteswatan Mani Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Anthony R. Cox , Gjalt W. Huisman , Ling Yuan , Joseph A. Affholter
CPC classification number: C12R1/465 , A01K2267/02 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12N15/90 , C12P17/162 , C12Q1/6811 , C12Q1/6827
Abstract: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
Abstract translation: 本发明提供了采用迭代循环重组和选择/筛选全细胞和生物体以获得所需性质的方法的方法。 这些性质的实例包括增加的重组原性，基因组拷贝数以及蛋白质和次级代谢物的表达和/或分泌能力。
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7.发明申请公开(公告)号：US20110257023A1
公开(公告)日：2011-10-20
申请号：US13168654
申请日：2011-06-24
Applicant: Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
Inventor： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
Abstract: The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
Abstract translation: 本发明一般涉及快速有效地搜索生物相关数据空间的方法。 更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。 本发明还提供了对序列活性关系建模的方法。 由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。
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8.发明授权公开(公告)号：US08849575B2
公开(公告)日：2014-09-30
申请号：US11429628
申请日：2006-05-05
Applicant: Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
Inventor： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
Abstract: The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
Abstract translation: 本发明一般涉及快速有效地搜索生物相关数据空间的方法。 更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。 本发明还提供了对序列活性关系建模的方法。 由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。
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9.发明申请公开(公告)号：US20110161265A1
公开(公告)日：2011-06-30
申请号：US12979637
申请日：2010-12-28
Applicant: Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
Inventor： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
Abstract: The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
Abstract translation: 本发明一般涉及快速有效地搜索生物相关数据空间的方法。 更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。 本发明还提供了对序列活性关系建模的方法。 由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。
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公开(公告)号：US07751986B2
公开(公告)日：2010-07-06
申请号：US11981577
申请日：2007-10-30
Applicant: Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
Inventor： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
Abstract: The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
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