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1.发明申请IMPLANT FOR RELEASING AN ACTIVE SUBSTANCE INTO A VESSEL THROUGH WHICH A BODY MEDIUM FLOWS 有权通过身体中流量将活性物质释放到血管内的植入物公开(公告)号：US20090182290A1
公开(公告)日：2009-07-16
申请号：US10597099
申请日：2005-02-04
申请人： Claus Harder , Roland Rohde , Bernd Heublein , Eva Heublein , Nora Heublein , Christoph Heublein , Erhard Flach , Wolfgang Geistert , Gernot Kolberg , Heinz Müller
发明人： Claus Harder , Roland Rohde , Bernd Heublein , Eva Heublein , Nora Heublein , Christoph Heublein , Erhard Flach , Wolfgang Geistert , Gernot Kolberg , Heinz Müller
IPC分类号： A61M5/00
CPC分类号： A61L31/022 , A61F2/86 , A61F2210/0004 , A61F2250/0068 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2300/604
摘要： The aim of the invention is to provide an implant for releasing an active substance into a vessel through which a body medium flows. This aim is achieved by the inventive implant for releasing an active substance into a vessel through which a body medium flows. Said implant comprises a base that consists of a biodegradable material as the carrier of the active substance to be released. The body medium flows around said base on the inside and/or outside thereof.
摘要翻译： 本发明的目的是提供一种用于将活性物质释放到体媒体通过其流动的容器中的植入物。 该目的通过本发明的用于将活性物质释放到体介质通过其流动的容器中来实现。 所述植入物包括由作为要释放的活性物质的载体的生物可降解材料组成的基底。 身体介质在其内部和/或外部围绕所述基座流动。
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2.发明授权Implant for releasing an active substance into a vessel through which a body medium flows 有权用于将活性物质释放到身体介质通过其流动的血管的植入物公开(公告)号：US09095642B2
公开(公告)日：2015-08-04
申请号：US10597099
申请日：2005-02-04
申请人： Claus Harder , Roland Rohde , Erhard Flach , Wolfgang Geistert , Gernot Kolberg , Heinz Müller , Eva Heublein , Nora Heublein , Christoph Heublein
发明人： Claus Harder , Roland Rohde , Bernd Heublein , Erhard Flach , Wolfgang Geistert , Gernot Kolberg , Heinz Müller
CPC分类号： A61L31/022 , A61F2/86 , A61F2210/0004 , A61F2250/0068 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2300/604
摘要： An implant for releasing an active substance into a vessel through which a body medium flows. The implant release an active substance into a vessel through which a body medium flows downstream from the location of the implant. A base of a biodegradable material is a carrier of the active substance to be released. The body medium flows past the implant and the active substance is release. The implant is configured so that the active substance does not contact a vessel wall at the location of implant.
摘要翻译： 用于将活性物质释放到体媒体通过其流动的容器中的植入物。 植入物将活性物质释放到容器中，身体介质通过该容器从植入物的位置流下游。 可生物降解材料的基底是要释放的活性物质的载体。 身体介质流过植入物，活性物质释放。 植入物构造成使得活动物质在植入物的位置处不接触血管壁。
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公开(公告)号：US09480585B2
公开(公告)日：2016-11-01
申请号：US11222595
申请日：2005-09-09
申请人： Bodo Gerold , Claus Harder , Bernd Heublein , Eva Heublein , Nora Heublein , Christoph Heublein , Heinz Mueller
发明人： Bodo Gerold , Claus Harder , Bernd Heublein , Heinz Mueller
CPC分类号： A61F2/86 , A61F2/90 , A61F2/91 , A61L31/022
摘要： The invention concerns an endovascular implant comprising a biodegradable material and having a tubular main body which is open at the ends and which is dilatable from an unexpanded condition into an expanded condition. The implant is so designed that when the implant in the expanded condition is subjected to a radially acting compression pressure in the range of between 5 and 30 kPa (0.05-0.3 bar) a cross-sectional area of the implant is reduced to 70% or less of the original cross-sectional area, or an internal volume of the implant is reduced to 70% or less of the original internal volume.
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公开(公告)号：US20060064160A1
公开(公告)日：2006-03-23
申请号：US11222595
申请日：2005-09-09
申请人： Bodo Gerold , Claus Harder , Bernd Heublein , Heinz Mueller , Eva Heublein , Nora Heublein , Christoph Heublein
发明人： Bodo Gerold , Claus Harder , Bernd Heublein , Heinz Mueller , Eva Heublein , Nora Heublein , Christoph Heublein
IPC分类号： A61F2/06
CPC分类号： A61F2/86 , A61F2/90 , A61F2/91 , A61L31/022
摘要： The invention concerns an endovascular implant comprising a biodegradable material and having a tubular main body which is open at the ends and which is dilatable from an unexpanded condition into an expanded condition. The implant is so designed that when the implant in the expanded condition is subjected to a radially acting compression pressure in the range of between 5 and 30 kPa (0.05-0.3 bar) a cross-sectional area of the implant is reduced to 70% or less of the original cross-sectional area, or an internal volume of the implant is reduced to 70% or less of the original internal volume.
摘要翻译： 本发明涉及一种包括可生物降解材料的血管内植入物，并且具有管状主体，该管状主体在端部处是开口的，并且可从未膨胀状态扩张到膨胀状态。 植入物的设计使得当处于膨胀状态的植入物经受5至30kPa（0.05-0.3巴）范围内的径向作用压缩压力时，植入物的横截面面积减小至70％或 较小的原始横截面积或植入物的内部体积减少到原始内部体积的70％或更小。
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公开(公告)号：US20100034899A1
公开(公告)日：2010-02-11
申请号：US12575596
申请日：2009-10-08
CPC分类号： A61L31/022 , A61F2/91 , A61F2/915 , A61F2002/9155 , A61L31/148
摘要： A method of treating a patient includes the medical use of one or more of the elements from the group yttrium, neodymium and zirconium, pharmaceutical formulations which contain said elements and implants which are at least region-wise made up of such formulations. It has been found inter alia that a formulation containing one or more of the elements has an action of inhibiting the proliferation of human smooth muscle cells.
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6.发明申请USE OF ONE OR MORE OF THE ELEMENTS FROM THE GROUP YTTRIUM, NEODYMIUM AND ZIRCONIUM, AND PHARMACEUTICAL COMPOSITIONS WHICH CONTAIN THOSE ELEMENTS 审中-公开使用来自集团YTTRIUM，NEODYMIUM和ZIRCONIUM的元素中的一种或多种元素，以及含有元素的药物组合物公开(公告)号：US20100119576A1
公开(公告)日：2010-05-13
申请号：US12575613
申请日：2009-10-08
CPC分类号： A61L31/022 , A61F2/91 , A61F2/915 , A61F2002/9155 , A61L31/148
摘要： A method of treating a patient includes the medical use of one or more of the elements from the group yttrium, neodymium and zirconium, pharmaceutical formulations which contain said elements and implants which are at least region-wise made up of such formulations. It has been found inter alia that a formulation containing one or more of the elements has an action of inhibiting the proliferation of human smooth muscle cells.
摘要翻译： 治疗患者的方法包括来自钇，钕和锆组的一种或多种元素的医学用途，含有所述元件的药物制剂和至少由这些制剂区域地构成的植入物。 已经发现，含有一种或多种元件的制剂具有抑制人平滑肌细胞增殖的作用。
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7.发明申请Use of one or more elements from the group containing yttrium, neodymium and zirconium and pharmaceutical compositions containing said elements 审中-公开使用一种或多种含有钇，钕和锆的元素以及含有所述元素的药物组合物公开(公告)号：US20060246107A1
公开(公告)日：2006-11-02
申请号：US10535084
申请日：2003-10-11
CPC分类号： A61L31/022 , A61F2/91 , A61F2/915 , A61F2002/9155 , A61L31/148
摘要： A method of treating a patient includes the medical use of one or more of the elements from the group yttrium, neodymium and zirconium, pharmaceutical formulations which contain said elements and implants which are at least region-wise made up of such formulations. It has been found inter alia that a formulation containing one or more of the elements has an action of inhibiting the proliferation of human smooth muscle cells.
摘要翻译： 治疗患者的方法包括来自钇，钕和锆组的一种或多种元素的医学用途，含有所述元件的药物制剂和至少由这些制剂区域地构成的植入物。 已经发现，含有一种或多种元件的制剂具有抑制人平滑肌细胞增殖的作用。
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公开(公告)号：US20050266041A1
公开(公告)日：2005-12-01
申请号：US10908729
申请日：2005-05-24
申请人： Bodo Gerold , Claus Harder , Heinz Mueller , Bernd Heublein , Eva Heublein , Nora Heublein , Christoph Heublein
发明人： Bodo Gerold , Claus Harder , Heinz Mueller , Bernd Heublein , Eva Heublein , Nora Heublein , Christoph Heublein
CPC分类号： A61L31/022 , A61L31/148
摘要： The invention concerns inter alia an implant for vessel ligature, the implant which comprises an alloy, wherein the alloy is at least partially biodegradable, and wherein the alloy comprises: greater than 87% magnesium; from about 3% to about 6% yttrium; from about 1% to about 5% lanthanide; and a balance of about 0.0% to about 2%.
摘要翻译： 本发明特别涉及用于血管结扎的植入物，包括合金的植入物，其中所述合金至少部分可生物降解，并且其中所述合金包括：大于87％的镁; 约3％至约6％的钇; 约1％至约5％的镧系元素; 余量约为0.0％至约2％。
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公开(公告)号：US20070191708A1
公开(公告)日：2007-08-16
申请号：US10596797
申请日：2004-03-31
申请人： Bodo Gerold , Claus Harder , Bernd Heublein , Heinz Muller , Eva Heublein , Nora Heublein , Christoph Heublein
发明人： Bodo Gerold , Claus Harder , Bernd Heublein , Heinz Muller , Eva Heublein , Nora Heublein , Christoph Heublein
CPC分类号： A61L31/18 , A61F2/82 , A61F2250/0098 , A61L27/047 , A61L27/58 , A61L31/148
摘要： The invention relates to a radio-opaque marker for medical implants. Said marker contains between 10 and 90 weight percent of a biodegradable base component, between 10 and 90 weight percent of one or more radio-opaque elements from the group containing I, Au, Ta, Y, Nb, Mo, Ru, Rh, Ba, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Hf, Ta, W, Re, Os, Ir and Bi as a marker component and 10 weight percent oF residual components, the aforementioned components amounting to 100 weight percent.
摘要翻译： 本发明涉及用于医疗植入物的不透射线标记物。 所述标记包含10至90重量％的可生物降解的基础组分，10至90重量％的一种或多种不透明元素来自含有I，Au，Ta，Y，Nb，Mo，Ru，Rh，Ba ，La，Ce，Pr，Nd，Sm，Eu，Gd，Tb，Dy，Ho，Er，Tm，Yb，Lu，Hf，Ta，W，Re，Os，Ir和Bi作为标记成分，10重量％ oF残留组分，上述组分总计为100重量％。
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公开(公告)号：US08871829B2
公开(公告)日：2014-10-28
申请号：US10596797
申请日：2004-09-07
申请人： Bodo Gerold , Claus Harder , Heinz Müller , Eva Heublein , Nora Heublein , Christoph Heublein
发明人： Bodo Gerold , Claus Harder , Bernd Heublein , Heinz Müller
CPC分类号： A61L31/18 , A61F2/82 , A61F2250/0098 , A61L27/047 , A61L27/58 , A61L31/148
摘要： A radio-opaque marker for medical implants comprising between 10 and 90 weight percent of a biodegradable base component, between 10 and 90 weight percent of one or more radio-opaque elements selected from the consisting of I, Au, Ta, Y, Nb, Mo, Ru, Rh, Ba, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Hf, Ta, W, Re, Os, Ir and Bi as a marker component and 10 weight percent of residual components, the aforementioned components amounting to 100 weight percent.
摘要翻译： 用于医用植入物的不透射线的标记物，其包含10-90重量％的可生物降解的基础成分，10-90重量％的一种或多种不透明元素，其选自I，Au，Ta，Y，Nb， Mo，Ru，Rh，Ba，La，Ce，Pr，Nd，Sm，Eu，Gd，Tb，Dy，Ho，Er，Tm，Yb，Lu，Hf，Ta，W，Re，Os，Ir和Bi 标记组分和10重量％的残余组分，前述组分总计为100重量％。
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