公开(公告)号：US12123086B2

公开(公告)日：2024-10-22

申请号：US17185521

申请日：2021-02-25

Applicant: BIOTRONIK AG

Inventor： Heinz Mueller ,  Peter Uggowitzer ,  Joerg Loeffler

IPC: C22F1/06 ,  A61F2/82 ,  A61L27/04 ,  A61L27/58 ,  A61L31/02 ,  A61L31/14 ,  C22C23/02

CPC classification number: C22F1/06 ,  A61F2/82 ,  A61L27/047 ,  A61L27/58 ,  A61L31/022 ,  A61L31/148 ,  C22C23/02

Abstract: A method for producing a magnesium alloy having improved mechanical and electrochemical properties. The method includes generating a high-purity magnesium by vacuum distillation. A billet of the alloy is generated by synthesis of the high-purity magnesium with 2.0 to 10.0% by weight Al, the remainder being magnesium containing impurities, which promote electrochemical potential differences and/or the formation of precipitations and/or intermetallic phases, in a total amount of no more than 0.0063% by weight of Fe, Si, Mn, Co, Ni, Cu, Zr, Y, Sc or rare earths having the ordinal numbers 21, 57 to 71 and 89 to 103, Be, Cd, In, Sn and/or Pb as well as P, wherein the matrix of the alloy includes intermetallic phases formed of Mg and Al. The alloy is homogenized by annealing at a temperature between 150° C. and 450° C. The homogenized alloy is formed in the temperature range between 200° C. and 400° C.

公开(公告)号：US20240325178A1

公开(公告)日：2024-10-03

申请号：US18738971

申请日：2024-06-10

Applicant: TriVascular, Inc.

Inventor： Jenine S. Vinluan ,  William P. Stephens ,  Mark Geusen ,  Carl H. Poppe ,  Christopher L. Staudenmayer ,  Michael V. Chobotov ,  James R. Watson ,  Teresa Woodson

IPC: A61F2/95 ,  A61F2/07 ,  A61F2/24 ,  A61F2/848 ,  A61F2/89 ,  A61F2/915 ,  A61F2/958 ,  A61L31/02

CPC classification number: A61F2/95 ,  A61F2/07 ,  A61F2/958 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2/243 ,  A61F2/848 ,  A61F2002/8483 ,  A61F2/89 ,  A61F2002/91591 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2250/0003 ,  A61F2250/0098 ,  A61L31/022

Abstract: Embodiments are directed in part to endovascular prostheses and methods of deploying same. Embodiments may be directed more specifically to stent grafts and methods of positioning and deploying such devices within the body of a patient.

公开(公告)号：US12059335B2

公开(公告)日：2024-08-13

申请号：US16999057

申请日：2020-08-20

Applicant: Osteogenics Biomedical, Inc.

Inventor： Barry K. Bartee ,  Chad M. Bartee ,  Istvan Urban

IPC: A61F2/28 ,  A61B17/06 ,  A61B17/08 ,  A61B17/84 ,  A61B17/86 ,  A61C8/02 ,  A61F2/00 ,  A61L27/18 ,  A61L27/56 ,  A61L31/02

CPC classification number: A61F2/0063 ,  A61B17/06166 ,  A61B17/08 ,  A61B17/84 ,  A61B17/846 ,  A61B17/86 ,  A61C8/0006 ,  A61F2/28 ,  A61F2/2846 ,  A61L27/18 ,  A61L27/56 ,  A61L31/022 ,  A61F2002/0068 ,  A61F2002/2835 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2250/0052 ,  A61L2430/02 ,  A61L2430/36

Abstract: This disclosure describes a membrane configured to guide bone and tissue regeneration for a bone defect. The membrane may comprise a first layer, a second layer, one or more perforations, a binder, and/or other components. The first layer of the membrane may be configured to contact bone. The first layer may include pores configured to promote ingrowth of bone regenerating cells into the first layer. In some implementations, the first layer may be a continuous sheet of microporous material without large perforations. The second layer may be configured to substantially prevent fibrous connective tissue from growing into the bone defect. The second layer may comprise a relatively dense structure. The second layer may be fixedly coupled to the first layer. In some implementations, the perforations may comprise co-axial through-holes having common dimensions through the first layer and the second layer. The perforations may be configured to enhance ossification.

公开(公告)号：US20240207075A1

公开(公告)日：2024-06-27

申请号：US17802448

申请日：2020-05-27

Applicant: BIOTYX MEDICAL (SHENZHEN) CO., LTD.

Inventor： Dong Bian ,  Wenjiao Lin

IPC: A61F2/82 ,  A61L31/02 ,  A61L31/08 ,  A61L31/10 ,  A61L31/16

CPC classification number: A61F2/82 ,  A61L31/022 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61F2250/0031 ,  A61F2250/0036 ,  A61F2250/0054 ,  A61F2250/0067

Abstract: Disclosed is an absorbable iron-based instrument (10). The absorbable iron-based instrument includes an iron-based matrix (100), a zinc-containing protective layer (200), a corrosion-promoting layer (300) and a drug controlled-release layer (400); the iron-based matrix (100) is provided with an outer wall (110), an inner wall (120) and a side wall (130); the zinc-containing protective layer (200) covers at least the outer wall (110) and the inner wall (120) of the iron-based matrix (100); the corrosion-promoting layer (300) fully covers the zinc-containing protective layer (200); the drug controlled-release layer (400) partially covers at least the corrosion-promoting layer (300); the corrosion-promoting layer (300) and the drug controlled-release layer (400) each contain degradable polymers; the weight-average molecular weight of the degradable polymers in the corrosion-promoting layer (300) is greater than the weight-average molecular weight of the degradable polymers in the drug controlled-release layer (400); and the thickness ratio of a portion of the zinc-containing protective layer (200) that is located at the inner wall (120) to a portion of the corrosion-promoting layer (300) that is located at the inner wall (120) is greater than the thickness ratio of a portion of the zinc-containing protective layer (200) that is located at the outer wall (110) to a portion of the corrosion-promoting layer (300) that is located at the outer wall (110). The corrosion behavior of the absorbable iron-based instrument (10) meets the requirements of clinical use, and the occurrence of adverse histological reactions is rare or avoided.

公开(公告)号：US12011175B2

公开(公告)日：2024-06-18

申请号：US17984128

申请日：2022-11-09

Applicant: Stryker Corporation ,  Stryker European Holdings I, LLC

Inventor： Hancun Chen

IPC: A61B17/12 ,  A61L31/02 ,  A61B17/00

CPC classification number: A61B17/1215 ,  A61B17/12031 ,  A61B17/12109 ,  A61B17/12113 ,  A61B17/1214 ,  A61B17/12168 ,  A61B17/12177 ,  A61L31/022 ,  A61B2017/00831 ,  A61B2017/00867 ,  A61B2017/00964 ,  A61L2430/36

Abstract: A vaso-occlusive device is constructed out of dissimilar metallic materials that are in contact or otherwise in close proximity with one another, thereby causing the device to undergo galvanic corrosion when exposed to an electrolytic medium, such as blood or other body fluid, wherein one of the dissimilar metallic materials is zirconium or zirconium alloy to create a corrosive product including zirconia having a relatively high hardness, a relatively high fracture toughness, and a relatively high stability when the device is implanted in a vasculature site, such as an aneurysm.

公开(公告)号：US12005155B2

公开(公告)日：2024-06-11

申请号：US17113635

申请日：2020-12-07

Applicant: Warsaw Orthopedic, Inc.

Inventor： James Davidson ,  William Rezach ,  Rodney Ballard

IPC: A61L31/02 ,  A61L27/04 ,  A61L27/50 ,  A61L31/14 ,  C22C27/00 ,  C22C27/04

CPC classification number: A61L27/047 ,  A61L27/50 ,  A61L31/022 ,  A61L31/14 ,  C22C27/00 ,  C22C27/04 ,  A61L2430/12 ,  A61L2430/22 ,  A61L2430/38

Abstract: Medical devices, such as implants, having a high-modulus alloy. The alloy includes a biocompatible refractory-metal-based alloy having multiple refractory metals. The alloy has an elastic modulus above about 300 GPa. The alloy comprises 30-35% tungsten, 60% molybdenum, and 5-10% niobium. The alloy is absent of rhenium.

公开(公告)号：US11986195B2

公开(公告)日：2024-05-21

申请号：US17274973

申请日：2019-10-16

Applicant: ANACONDA BIOMED, SL

Inventor： Ignacio Cortiñas Villazón ,  Ane Lizarazu González ,  Ofir Arad Hadar ,  Iñaki Galve Murillo

IPC: A61B17/221 ,  A61L31/02 ,  A61L31/10 ,  A61B17/22

CPC classification number: A61B17/221 ,  A61L31/022 ,  A61L31/10 ,  A61B2017/22079 ,  A61B2017/2212

Abstract: A device, a thrombectomy apparatus and a method for extraction of thrombus from a blood vessel are disclosed. The device comprises a segment changing its shape from a retracted position in a compressed state to an extended and expanded position. The segment is formed by a mesh of at least two sets of helicoidal filaments turning respectively in opposite directions and being intertwined. The mesh comprises two distinct tubular sections. The mesh of the first section has helicoidal filaments with a braiding angle providing radial forces higher than in the second section, thus the first section becomes appositioned against the inner wall of the blood vessel. The second section comprises two sub-sections. The first sub-section has a conical shape and comprises a braiding angle changing at its proximal and distal ends to provide radial strength to maintain the conical shape and to stop a proximal blood flow during the removal of the thrombus.

公开(公告)号：US11980410B2

公开(公告)日：2024-05-14

申请号：US16152769

申请日：2018-10-05

Applicant: Regents of the University of Minnesota

Inventor： Samira M. Azarin ,  Francisco Pelaez ,  Navid Manuchehrabadi ,  John C. Bischof

IPC: A61B18/08 ,  A61F7/00 ,  A61L31/02 ,  A61L31/10 ,  A61L31/14 ,  A61B18/00

CPC classification number: A61B18/08 ,  A61F7/00 ,  A61L31/022 ,  A61L31/10 ,  A61L31/14 ,  A61L31/146 ,  A61B2018/00065 ,  A61B2018/00077 ,  A61B2018/00113 ,  A61B2018/00136 ,  A61B2018/00577 ,  A61B2018/087 ,  A61F2007/009 ,  A61L2400/08 ,  A61L2400/18 ,  A61L31/10 ,  C08L67/04

Abstract: A device includes an electrically conductive or electrically semiconductive material and a biocompatible porous scaffold around the electrically conductive or electrically semiconductive material. The biocompatible porous scaffold includes a biocompatible polymer and pores configured to capture metastatic cells.

公开(公告)号：US20240138809A1

公开(公告)日：2024-05-02

申请号：US18396973

申请日：2023-12-27

Applicant: FUJIFILM Corporation

Inventor： Kazushi Furukawa ,  Yoshihiro Nakai

IPC: A61B8/00 ,  A61L31/02 ,  A61L31/06 ,  A61L31/12 ,  A61L31/14

CPC classification number: A61B8/4281 ,  A61L31/022 ,  A61L31/06 ,  A61L31/128 ,  A61L31/14

Abstract: Provided are an acoustic matching layer material containing a curing reaction product obtained by reacting an epoxy resin (A) having an epoxy equivalent weight of 140 or less with at least one of a curing agent (B-1) which is a monomer or a curing catalyst (B-2), and metal particles (C) having a density of 4.5 g/cm3 or more and less than 10 g/cm3 at 20° C., in which a content of particles (D) having a density of less than 4.5 g/cm3 at 20° C. is less than 5% by mass; an acoustic matching sheet; a composition for an acoustic matching layer material; an acoustic wave probe; an acoustic wave measurement apparatus; and a manufacturing method of an acoustic wave probe.

公开(公告)号：US11969519B1

公开(公告)日：2024-04-30

申请号：US18324388

申请日：2023-05-26

Applicant: Bioretec Oy

Inventor： Timo Lehtonen ,  Kimmo Lähteenkorva ,  Anna-Maija Haltia ,  Christopher Stahle

IPC: A61L27/00 ,  A61F2/28 ,  A61F2/30 ,  A61L27/04 ,  A61L27/44 ,  A61L27/58 ,  A61L31/02 ,  A61L31/14 ,  C22C1/02 ,  C22C23/00 ,  C22F1/06

CPC classification number: A61L27/047 ,  A61L27/042 ,  A61L27/446 ,  A61L27/58 ,  A61L31/022 ,  A61L31/148 ,  C22C1/02 ,  C22C23/00 ,  C22F1/06 ,  A61L2420/02

Abstract: The present application provides an orthopedic implant or a part thereof, comprising biodegradable magnesium alloy comprising magnesium and Ca in the range of 0.550-0.700 wt %, Zn in the range of 0.400-0.700 wt %, and Fe 50 ppm or less, the biodegradable magnesium alloy consisting of two phases comprising a first phase comprising magnesium and Zn and a second phase less noble than the first phase, the second phase comprising Mg2Ca precipitates larger than nano-sized. The present application also provides a method for preparing the biodegradable magnesium alloy, a method for preparing the orthopedic implant or the part thereof, and a method for treating a subject in need of therapy for a medical condition of a bone.