公开(公告)号：US20180346963A1

公开(公告)日：2018-12-06

申请号：US15994624

申请日：2018-05-31

Applicant: Counsyl, Inc.

Inventor： Noah C. Welker ,  Clement S. Chu

IPC: C12Q1/6806 ,  C12Q1/6869

Abstract: Methods for preparing concatenated nucleic acid molecules are provided. The methods herein include adaptors with complementary sequences for preparation of concatenated nucleic acid molecules, and methods of sequencing such nucleic acids.

公开(公告)号：US20180216176A1

公开(公告)日：2018-08-02

申请号：US15873687

申请日：2018-01-17

Applicant: Counsyl, Inc.

Inventor： Clement S. Chu ,  Noah C. Welker ,  Henry H. Lai

IPC: C12Q1/6869 ,  C12N15/10 ,  C12N9/00 ,  C12Q1/686

CPC classification number: C12Q1/6869 ,  C12N9/93 ,  C12N15/1031 ,  C12Q1/6809 ,  C12Q1/686 ,  C12Q2600/156 ,  C12Q2525/191 ,  C12Q2531/113 ,  C12Q2535/101 ,  C12Q2535/122

Abstract: High-fidelity, high-throughput nucleic acid sequencing enables healthcare practitioners and patients to gain insight into genetic variants and potential health risks. However, previous methods of nucleic acid sequencing often introduce sequencing errors (for example, mutations that arise during the preparation of a nucleic acid library, during amplification, or sequencing). Provided herein are methods and compositions for sequencing nucleic acids. Further provided are methods of identifying an error in a nucleic acid sequence.